35779-35-2

Basic information

• Product Name: DIPYRIDIN-3-YLMETHANONE
• Synonyms: Nsc170628;dipyridin-3-ylmethanone(SALTDATA: FREE)
• CAS NO: 35779-35-2
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.2
• Mol File: 35779-35-2.mol

Chemical Properties

• Melting Point: 115.5-117.0 °C
• Boiling Point: 346.8 °C at 760 mmHg
• Flash Point: 167.6 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 5.63E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.81±0.10(Predicted)
• CAS DataBase Reference: DIPYRIDIN-3-YLMETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPYRIDIN-3-YLMETHANONE(35779-35-2)
• EPA Substance Registry System: DIPYRIDIN-3-YLMETHANONE(35779-35-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 35779-35-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Dipyridin-3-ylmethanone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate multiple chemical reactions, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, dipyridin-3-ylmethanone is utilized as a component in the production of pesticides and other agrochemicals, enhancing their effectiveness and contributing to agricultural productivity.
Used in Functional Materials Industry:
Dipyridin-3-ylmethanone is employed as a building block in the creation of functional materials, such as advanced polymers and composites, due to its versatility in chemical synthesis and its ability to impart specific properties to these materials.
Used in Organic Synthesis:
As a versatile chemical intermediate, dipyridin-3-ylmethanone is used in organic synthesis for its capacity to participate in a wide range of chemical reactions, enabling the production of diverse organic compounds for various applications.

InChI:InChI=1/C11H8N2O/c14-11(9-3-1-5-12-7-9)10-4-2-6-13-8-10/h1-8H

Upstream product

• 60573-68-4 3-pyridyllithium 
• 100-54-9 pyridine-3-carbonitrile 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 59-67-6 nicotinic acid 
• 89667-15-2 α-(3-Pyridyl)-3-pyridinmethanol 
• 626-55-1 3-Bromopyridine 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 109-72-8 n-butyllithium 
• 500-22-1 3-pyridinecarboxaldehyde 
• 220565-63-9 pyridin-3-ylzinc(II) bromide 
• 28122-96-5 S-phenyl pyridine-3-carbothioate 

Downstream Products

• 22125-05-9 Phenyl-di-[3]pyridyl-methanol 
• 879081-88-6 2,6-di-tert-butyl-4-(hydroxy-di-pyridin-3-yl-methyl)-phenol 
• 879081-80-8 2,6-di-tert-butyl-4-(di-pyridin-3-yl-methylene)-cyclohexa-2,5-dienone 
• 1355718-60-3 (dipyridin-3-ylmethyl)triphenylphosphonium bromide 
• 1600563-75-4 (2,4-dichloro-3-phenylquinolin-6-yl)(dipyridin-3-yl)methanol trifluoroacetate 
• 89667-15-2 α-(3-Pyridyl)-3-pyridinmethanol 
• 78210-43-2 5,5-methylenebis(pyridine) 

Relevant articles and documents

Helical and zigzag coordination polymeric chains derived from di-3-pyridyl ketone and silver(I) salts

A series of silver(I) complexes [AgL(X)]∞ (X=BF 4, ClO4, NO3, CF3SO3, PF6; L=di-3-pyridyl ketone) have been characterized by X-ray crystallography. Argentophilic interaction, π-π stacking, Ag?X interaction, C-H?X (X=F, O) and C-H?O=C hydrogen bonding contribute to different extents in the construction of helical or zigzag infinite chains.

Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.

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The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomolecule-inspired catalytic cycle wherein high levels of asymmetric induction are provided by aspartic-acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of hydrogen bonding to the catalyst are demonstrated. Our approach presents a new entry into chiral pyridine frameworks in a heterocycle-rich molecular environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asymmetric N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines.

Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation

We developed a palladium-catalyzed C-H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C-H bond activation pathway.

Synthesis and photoluminescent properties of new ceramidine derivatives

A series of new ceramidine derivatives 8a-f has been synthesized in 4-5 steps involving a Wittig reaction of ceramidonine with various triphenylphosphonium bromides. Their UV and photoluminescence (PL) properties are reported. The compounds showed medium to strong PL between 502 and 522 nm at a concentration of 1 × 10-5 M CH2Cl2.

NEW COMPOUNDS I/418

There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

POTASSIUM CHANNEL INHIBITORS

The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

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Fungicidal Pyridine Derivatives I: α-Trichloromethyl-3-pyridinemethanols

The title substances, a new type of compounds with fungicidal activity, were synthesized by addition of trichloromethyllithium (and tribromomethyllithium resp.) to various 3-pyridyl ketones at -100 deg C. - Keywords: Fungicides; Pyridinemethanoles; Trichl