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Nicotinic acid
Cas No: 59-67-6
USD $ 1.0-1.0 / Kilogram 25 Kilogram 1000 Metric Ton/Quarter EXCELLENT HEALTH PRODUCTS CO.,LTD Contact Supplier
Nicotinic acid
Cas No: 59-67-6
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Nicotinic acid, food additive and API
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Nicotinic acid
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59-67-6 Usage

Uses

Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied

Purification Methods

Crystallise the acid from *benzene, EtOH or H2O. It sublimes without decomposition. [McElvain Org Synth Coll Vol I 385 1941, Beilstein 22 III/IV 439, 22/2 V 57.]

Uses

anti-hyperlipoproteinemic

Chemical Properties

White powder

Uses

antihyperlipidemic, vitamin (enzyme cofactor)

Brand name

Niacor (Upsher Smith); Niaspan (KOS); Nicolar (Sanofi Aventis); Wampocap (Medpointe).

Uses

Niacin USP granular is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals. WWW Link

Uses

  • This product is a type of vitamin supplement, and it is called vitamin PP along with nicotinamide. It is used to treat pellagra and as a vasodilator, and it is widely used as an additive for food and feed.
  • A medicine intermediate, used in the production of isoniazid, nicotinamide, nikethamide, inositol nicotinate, etc.
  • Nicotinic acid is an important factor in delivering hydrogen and fighting pellagra in organisms; it helps maintain skin and nerve health and stimulate digestion.
  • Coenzyme and cofactor; pyridine nucleotide coenzyme; decreases the amount of low density lipoproteins in the liver and slows the fibrosis of apolipoproteins.
  • Biochemistry research, a nutritional component of tissue culture mediums.

Air & Water Reactions

Water soluble.

Definition

ChEBI: A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Reactivity Profile

Nicotinic acid is incompatible with strong oxidizers. Nicotinic acid is also incompatible with sodium nitrite.

Fire Hazard

Flash point data for Nicotinic acid are not available; however, Nicotinic acid is probably combustible.

Content analysis

Precisely take a sample of 300mg and dissolve in 50ml water. Add a couple drops of phenolphthalein solution (TS-167) and titrate using 0.1mol/L sodium hydroxide. Conduct a control experiment at the same time. Every Ml0.1mol/L sodium hydroxide is equivalent to 12.31mg nicotinic acid (C6H5NO2).

Identifying tests

Add 2 portions of 2, 4-Dinitrochlorobenzene to the sample and process into powder. Place 10mg of the powder in a test tube, gently heat until melted, and continue to heat for a couple of seconds. Cool and add 3ml potassium hydroxide ethanol solution (TS-190). The solution should be dark red.
Dissolve 50mg of the sample solution in 20ml water, use 0.1mol/L sodium hydroxide to neutralize until a litmus paper reads neutral, and add 3ml copper sulfate solution (TS-78). Blue precipitate should begin forming slowly.
Dry the sample for 1h at 105℃ and collect its mineral oil dispersions. The peak wavelength of its infrared absorption spectrum should resemble the standard reference sample formulated using the same method.
Prepare an aqueous solution of the sample with a density of 20μg/ml, measure its absorbance at the wavelengths 237nm and 262nm in a 1cm pool, using water as a blank control. A237/A262 should be 0.35~0.39.

Uses

Niamax(R) is a brand name for a sustained release Niacin tablet, which is used to reduce cholesterol. Contact

General Description

Odorless white crystalline powder with a feebly acid taste. pH (saturated aqueous solution) 2.7. pH (1.3% solution) 3-3.5.

Toxicity

LD50 7.0g/kg (Large mice, oral).
GRAS(FDA,§182.5530,2000)。
ADI has no special regulations (EEC, 1990).

Preparation

Nicotinic acid exists naturally in grain germs, meats and peanuts. It can also be synthesized artificially through the liquid phase method (potassium permanganate oxidation and nitric acid oxidation) and gas phase method (ozone oxidation, ammonia oxidation and air oxidation).
  • 3-methyl pyridine method
In the gas phase ammonia oxidation process, add 3-methyl pyridine, air and ammonia into the fluidized bed reactor and catalyze the reaction at 290~360℃,V2O5 to produce nicotinonitrile; then hydrolyze in sodium hydroxide aqueous solution at 160℃ to produce sodium nicotinate; finally, add hydrochloric acid to acidify, creating nicotinic acid. In the potassium permanganate oxidation method, add potassium permanganate gradually at 80℃ to a mixture of 3-methyl pyridine and water, and then continue to mix for 30min at 85~90℃. Distill to collect and reuse the unreacted 3-methyl pyridine and filter away the produced manganese dioxide. Adjust the PH of the resulting nicotinic acid solution to 3.8~4.0 using hydrochloric acid, cool to 30℃ crystals, and filter to obtain crude nicotinic acid. Dissolve the crude nicotinic acid in hot water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product. Yield is approximately 86%.
  • 6- hydroxyquinoline method
Add sulfuric acid and quinoline into a reaction kettle and mix while maintaining heat at 150~160℃ for 5h. Then with the temperature maintained at 180~220℃, slowly drop in nitric acid and the sulfuric acid mixture over the course of 36~40h. While maintaining the temperature, mix for 2~3h to obtain a nicotinic acid solution and add water to dilute the solution. Use 30%~33% NaOH solution to neutralize the PH to 8~9. Cool and filter away the sodium sulfate and sodium nitrate crystals, add copper sulfate solution to the filtered liquid, and mix and heat to yield copper nicotinate precipitation. Cool, filter and add the copper nicotinate to an adequate amount of water, drop in NaOH solution until PH>9 and the liquid is no longer blue, and filter away the produced cupric oxide. Add a small amount of sodium sulfide solution to remove traces of copper and iron until the solution no longer produces black precipitate, and then filter. Use hydrochloric acid to adjust the PH of the filtered liquid to 3.5~3.9, filter to yield crystals as crude nicotinic acid. Dissolve the crude product in 12 times the amount of distilled water, add activated charcoal to eliminate the color, filter, cool, and obtain the crystalline end product. Yield is 35%~39%.
  • 2-methyl-5-ethyl pyridine method
With 2-methyl-5-ethyl pyridine as the raw ingredient, oxidize with nitic acid under high pressure and high temperatures, then decarboxylate to yield nicotinic acid.

Chemical Properties

White crystal or crystalline powder, odorless or has a slight odor, slight sour taste. Melting point is 234-237℃. Easily soluble in hot water, hot ethanol, alkaline water, propylene glycol, and chloroform. Slightly soluble in water and ethanol; 100ml room temperature water can dissolve 1.6g. Insoluble in ether and ester solutions. The PH of 1% aqueous solution is 3.0-4.0. Stable in heat, acidity and alkalinity.

Uses

Niacin USP is used for food fortification, as dietary supplement and as an intermediate of pharmaceuticals. WWW Link

Uses

Niacin feed grade is used as vitamin for poultry, swines, ruminants, fish, dogs and cats, etc. It is also used as intermediate for nicotinic acid derivatives and technical applications. WWW Link
InChI:InChI=1/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

59-67-6 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Cerilliant (V-017)  Nicotinic acid (Vitamin B3) solution  1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 59-67-6 V-017-1ML 716.04CNY Detail
Supelco (47864)  Nicotinicacid  analytical standard 59-67-6 000000000000047864 207.09CNY Detail
USP (1461003)  Niacin  United States Pharmacopeia (USP) Reference Standard 59-67-6 1461003-200MG 4,662.45CNY Detail
Sigma-Aldrich (N0700000)  Nicotinicacid  European Pharmacopoeia (EP) Reference Standard 59-67-6 N0700000 1,880.19CNY Detail
Sigma-Aldrich (PHR1276)  Niacin(NicotinicAcid)  pharmaceutical secondary standard; traceability to USP and BP 59-67-6 PHR1276-1G 732.19CNY Detail
Fluka (72311)  Nicotinicacid  matrix substance for MALDI-MS, ≥99.5% (HPLC) 59-67-6 72311-1G 1,889.55CNY Detail
Fluka (72311)  Nicotinicacid  matrix substance for MALDI-MS, ≥99.5% (HPLC) 59-67-6 72311-250MG 586.17CNY Detail
Alfa Aesar (A12683)  Nicotinic acid, 99%    59-67-6 5000g 2804.0CNY Detail
Alfa Aesar (A12683)  Nicotinic acid, 99%    59-67-6 1000g 607.0CNY Detail
Alfa Aesar (A12683)  Nicotinic acid, 99%    59-67-6 250g 215.0CNY Detail
TCI America (N0082)  Nicotinic Acid  >99.0%(HPLC)(T) 59-67-6 500g 410.00CNY Detail
TCI America (N0082)  Nicotinic Acid  >99.0%(HPLC)(T) 59-67-6 25g 105.00CNY Detail

59-67-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Nicotinic acid

1.2 Other means of identification

Product number -
Other names Pyridine-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59-67-6 SDS

59-67-6Synthetic route

Pyridine-2,5-dicarboxylic acid
100-26-5

Pyridine-2,5-dicarboxylic acid

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With water at 230℃; for 2h;99.9%
With water at 205℃;
With water at 175 - 180℃; under 22065.2 Torr;
3-Methylpyridine
108-99-6

3-Methylpyridine

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With oxygen; V2O5/Sb2O3-TiO2 In water at 260 - 280℃; Industry scale; Inert atmosphere; Gas phase;99.58%
With oxygen; V2O5/Sb2O3-TiO2 In water at 260 - 280℃; Product distribution / selectivity; Inert atmosphere; Gas phase; Industry scale;99.58%
With water; oxygen Product distribution / selectivity;97.3%
ETOFIBRATE
31637-97-5

ETOFIBRATE

A

nicotinic acid
59-67-6

nicotinic acid

B

Clofibric acid
882-09-7

Clofibric acid

C

ethylene glycol
107-21-1

ethylene glycol

Conditions
ConditionsYield
With hydrogenchloride; [RuCl2(CO)2(Ph2P-3-C6H4COOH)2] In methanol; water at 75℃; for 0.333333h;A 99.1%
B n/a
C n/a
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In water at 30℃; for 24h; Enzymatic reaction;99%
With C4H11FeMo6NO24(3-)*3C16H36N(1+); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 8h; Green chemistry;99%
With 4H3N*4H(1+)*CuMo6O18(OH)6(4-); water; oxygen; sodium carbonate at 50℃; under 760.051 Torr; for 12h;99%
3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With tert-butyldimethylsilyl chloride In methanol; water at 20℃; for 0.5h; Reagent/catalyst; Green chemistry;99%
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In aq. buffer at 20℃; for 12h; pH=9.8 - 10.1; Electrolysis;96%
With ferrous(II) sulfate heptahydrate; Oxone In water at 20℃; for 0.5h; Sonication; Green chemistry;94%
3-pyridinecarboxylic acid ethyl ester
614-18-6

3-pyridinecarboxylic acid ethyl ester

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With PPA at 155℃; for 4.5h;98%
With alkaline H2O In dimethyl sulfoxide at 30℃; Rate constant; other solvent (EtOH); variation of water concentrations;
esterase in WBN; IL-Ht rat abdominal skin homogenate at 37℃; Enzyme kinetics;
methyl-3-oxo-3-(pyridin-3-yl)propanedithioate
1312414-21-3

methyl-3-oxo-3-(pyridin-3-yl)propanedithioate

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 10h; Reflux; chemoselective reaction;98%
quinoline-5-sulfonic acid
23261-58-7

quinoline-5-sulfonic acid

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With sulfuric acid; selenium at 240 - 300℃; for 1h; Product distribution; reaction time; SeO2 as catal.;95%
C8H6Cl3NO2

C8H6Cl3NO2

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With indium; ammonium chloride In tetrahydrofuran for 11h; Heating;95%
3-iodopyridine
1120-90-7

3-iodopyridine

diphenylmethylsilanecarboxylic acid
18414-58-9

diphenylmethylsilanecarboxylic acid

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With potassium trimethylsilonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In toluene at 40℃; for 0.333333h;95%
3-Methylpyridine
108-99-6

3-Methylpyridine

A

nicotinic acid
59-67-6

nicotinic acid

B

carbon dioxide
124-38-9

carbon dioxide

Conditions
ConditionsYield
With water; oxygen at 310℃; Product distribution / selectivity;A 93.13%
B 5.56%
With water; oxygen at 300℃; Product distribution / selectivity;A 93.16%
B 6.39%
With water; oxygen at 285℃; Product distribution / selectivity;A 92.22%
B 7.11%
nicotinamide
98-92-0

nicotinamide

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With tert.-butylnitrite; acetic acid at 75℃; for 2.5h; Inert atmosphere;92%
With niobium(V) oxide; water In neat (no solvent) for 20h; Reflux; Inert atmosphere;83%
With barium dihydroxide In water for 1h; Heating;
With recombinant Borrelia burgdorferi nicotinamidase at 25℃; pH=7.3; Kinetics; Reagent/catalyst; Concentration; aq. phosphate buffer; Enzymatic reaction;
With water In aq. phosphate buffer at 30℃; for 6h; pH=7; Time; Enzymatic reaction;41.66 mmol
1-(4-methoxyphenyl)-2-(pyridin-3-yl)-ethanone
52700-25-1

1-(4-methoxyphenyl)-2-(pyridin-3-yl)-ethanone

A

nicotinic acid
59-67-6

nicotinic acid

B

4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

Conditions
ConditionsYield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;A 92%
B 92%
pyridine-3-ylglyoxal
63464-84-6

pyridine-3-ylglyoxal

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With iodine; dimethyl sulfoxide at 180℃; for 0.0833333h; Inert atmosphere; Microwave irradiation;91%
3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

A

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

B

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With sodium hypochlorite; C8H18NPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;A 90.1%
B 3.4%
With sodium hypochlorite; C13H26N2OPol; sodium hydrogencarbonate In water; toluene at 15 - 20℃; for 4.5h; Product distribution / selectivity;A 87.7%
B 3.5%
With sodium hypochlorite; C16H28N2O5Pol; sodium hydrogencarbonate In water; 1,2-dichloro-ethane at 15 - 20℃; for 4.5h; Product distribution / selectivity;A 85.3%
B 5.3%
8-quinolinesulfonic acid
85-48-3

8-quinolinesulfonic acid

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With sulfuric acid; selenium at 240 - 300℃; for 1h; Product distribution; reaction time; SeO2 as catal.;90%
methyl-3-pyridylketone
350-03-8

methyl-3-pyridylketone

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With Oxone; trifluoroacetic acid In 1,4-dioxane for 10h; Reflux; Green chemistry;90%
With copper(l) iodide; hydroxylamine hydrochloride; oxygen In dimethyl sulfoxide at 100℃; for 12h;68%
1,2-di(pyridin-3-yl)ethan-1-one
6339-93-1

1,2-di(pyridin-3-yl)ethan-1-one

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With oxygen; potassium hydroxide at 20℃; Schlenk technique; chemoselective reaction;90%
3-Methylpyridine
108-99-6

3-Methylpyridine

2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide
2196-95-4, 17213-48-8

2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A

pyridine
110-86-1

pyridine

B

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

C

nicotinic acid
59-67-6

nicotinic acid

D

2,2'-diphenyl-1H,1'H-3,3'-biindole
2415-33-0

2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions
ConditionsYield
at 140℃; for 14h; Product distribution;A 5%
B 18%
C 60%
D 88%
at 140℃; for 14h; Further byproducts given;A 5%
B 18%
C 60%
D 88%
2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide
2196-95-4, 17213-48-8

2,2'-diphenyl-[3,3']biindolylidene 1,1'-dioxide

A

pyridine
110-86-1

pyridine

B

3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

C

nicotinic acid
59-67-6

nicotinic acid

D

2,2'-diphenyl-1H,1'H-3,3'-biindole
2415-33-0

2,2'-diphenyl-1H,1'H-3,3'-biindole

Conditions
ConditionsYield
With 3-Methylpyridine at 140℃; for 14h; Further byproducts given;A 5%
B 18%
C 60%
D 88%
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

A

nicotinic acid
59-67-6

nicotinic acid

B

1,2-di(pyridine-3-yl)ethane-1,2-dione
35779-39-6

1,2-di(pyridine-3-yl)ethane-1,2-dione

Conditions
ConditionsYield
With 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In aq. buffer at 20℃; for 8h; pH=11.5; Electrolysis;A 86%
B 6%
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With pyridine for 30h; Heating; other temperature, other reactant ratio, sealed tube;85%
With 2,3-dimethyl-2,3-butane diol; bis(N,N-dimethylformamide)dichloridodioxidomolybdenum(VI) In N,N-dimethyl acetamide at 130℃; Microwave irradiation; Sealed tube; Green chemistry; chemoselective reaction;84%
With molybdenum(V) chloride; sodium iodide In acetonitrile at 20℃; for 2h;83%
3-picolyl bromide
69966-55-8

3-picolyl bromide

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With 5,10,15,20-tetra(4-nitrophenyl) porphyrinato iron chloride; [bis(acetoxy)iodo]benzene; water In methanol at 50℃; for 12h;85%
Myosmine
532-12-7

Myosmine

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With D-glucose at 200℃; for 1h; pH=7.5; Temperature; pH-value;84%
3-pyridinecarboxaldehyde
500-22-1

3-pyridinecarboxaldehyde

A

3-hydroxymethylpyridin
100-55-0

3-hydroxymethylpyridin

B

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With TEA; magnesium bromide In dichloromethane at 20℃; for 48h; Cannizzaro reaction;A 82%
B n/a
With N,N,N',N'-tetramethylguanidine In water at 20℃; for 7h; Cannizzaro reaction;A 44%
B 41%
With barium dihydroxide; formaldehyd at 100 - 110℃; for 0.0333333h; Irradiation;A 97 % Chromat.
B 3 % Chromat.
With aluminum oxide; sodium hydroxide; water for 0.00416667h; Irradiation; Yield given; Yields of byproduct given;
3-Bromopyridine
626-55-1

3-Bromopyridine

potassium formate
590-29-4

potassium formate

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With [PhCOPd(PtBu3)I]; dtbpf In 2-methyltetrahydrofuran at 80℃; for 18h; Inert atmosphere;82%
3-iodopyridine
1120-90-7

3-iodopyridine

molybdenum hexacarbonyl
13939-06-5, 199620-15-0

molybdenum hexacarbonyl

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With C35H20F34NO3(1-)*Pd(2+)*Cl(1-); water; N-ethyl-N,N-diisopropylamine at 130℃; for 0.333333h; Microwave irradiation;81%
6-iodo-nicotinic acid
13054-02-9

6-iodo-nicotinic acid

nicotinic acid
59-67-6

nicotinic acid

Conditions
ConditionsYield
With hydrogenchloride; indium In water for 2h; Reflux;80%
With indium In water for 5h; Heating;57%
nicotinic acid
59-67-6

nicotinic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl nicotinate
94-44-0

benzyl nicotinate

Conditions
ConditionsYield
With N,N-bis[2-oxo-3-oxazolidinyl]phosphorodiamidic chloride In dichloromethane for 1h; Ambient temperature;100%
With N,N'-dimethylaminopyridine; di-tert-butyl dicarbonate In nitromethane at 50℃; for 16h;81%
With boric acid; glycerol Entfernen des entstehenden H2O;
nicotinic acid
59-67-6

nicotinic acid

pyridine-3-carbonyl chloride hydrochloride
20260-53-1

pyridine-3-carbonyl chloride hydrochloride

Conditions
ConditionsYield
With thionyl chloride for 4h; Heating;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Inert atmosphere;100%
With thionyl chloride In toluene at 100℃; for 24h;100%
nicotinic acid
59-67-6

nicotinic acid

1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

nicotinic acid succinimidyl ester
78348-28-4

nicotinic acid succinimidyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In 1,4-dioxane100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 48h;85%
With dicyclohexyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;80%
nicotinic acid
59-67-6

nicotinic acid

3-pyridinecarbonyl chloride
10400-19-8

3-pyridinecarbonyl chloride

Conditions
ConditionsYield
With thionyl chloride for 5h; Reflux;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; Cooling with ice;100%
With oxalyl dichloride at 20℃; for 0.5h;100%
nicotinic acid
59-67-6

nicotinic acid

(3R,4R)-4-[4-(2-Hydroxy-ethoxy)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester

(3R,4R)-4-[4-(2-Hydroxy-ethoxy)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester

Nicotinic acid 2-{4-[(3R,4R)-1-tert-butoxycarbonyl-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy}-ethyl ester

Nicotinic acid 2-{4-[(3R,4R)-1-tert-butoxycarbonyl-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-phenoxy}-ethyl ester

Conditions
ConditionsYield
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane Ambient temperature;100%
nicotinic acid
59-67-6

nicotinic acid

4-(5-nitro-1H-indol-1-yl)-1-butanol
578725-98-1

4-(5-nitro-1H-indol-1-yl)-1-butanol

nicotinic acid 4-(5-nitro-indol-1-yl)-butyl ester
578726-03-1

nicotinic acid 4-(5-nitro-indol-1-yl)-butyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;100%
nicotinic acid
59-67-6

nicotinic acid

N-((piperidin-4-yl)methyl)-N'-(adamant-1-yl)urea hydrochloride

N-((piperidin-4-yl)methyl)-N'-(adamant-1-yl)urea hydrochloride

N-((1-(pyridine-3-carbonyl)piperidin-4-yl)methyl)-N'-(adamant-1-yl)urea

N-((1-(pyridine-3-carbonyl)piperidin-4-yl)methyl)-N'-(adamant-1-yl)urea

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In dichloromethane at 0 - 20℃; for 20h;100%
(1-S)-{4-[(5-tert-butoxycarbonylamino-1-hydroxymethyl-pentyl)-isobutyl-sulfamoyl]-phenyl}-carbamic acid tert-butyl ester
900187-22-6

(1-S)-{4-[(5-tert-butoxycarbonylamino-1-hydroxymethyl-pentyl)-isobutyl-sulfamoyl]-phenyl}-carbamic acid tert-butyl ester

nicotinic acid
59-67-6

nicotinic acid

(2S)-nicotinic acid 6-tert-butoxycarbonylamino-2-[(4-tert-butoxycarbonylamino-benzenesulfonyl)-isobutyl-amino]-hexyl ester
874339-83-0

(2S)-nicotinic acid 6-tert-butoxycarbonylamino-2-[(4-tert-butoxycarbonylamino-benzenesulfonyl)-isobutyl-amino]-hexyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DMF (N,N-dimethylformamide) at 20℃;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃;100%
nicotinic acid
59-67-6

nicotinic acid

4-bromo-N2-methylbenzene-1,2-diamine
337915-79-4

4-bromo-N2-methylbenzene-1,2-diamine

C13H12BrN3O
1038408-42-2

C13H12BrN3O

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU; dmap In N,N-dimethyl-formamide at 0 - 20℃; for 2.16667h;100%
nicotinic acid
59-67-6

nicotinic acid

nicotinic acid sulfate
64030-04-2

nicotinic acid sulfate

Conditions
ConditionsYield
With sulfuric acid In dichloromethane at 20℃; Cooling with ice;100%
With sulfuric acid In dichloromethane at 20℃; for 0.5h;100%
nicotinic acid
59-67-6

nicotinic acid

methyl pyrrolidine-2-carboxylate
43041-12-9, 52183-82-1, 2577-48-2

methyl pyrrolidine-2-carboxylate

1-(pyridine-3-carbonyl)pyrrolidine-2-carboxylic acid methyl ester
955038-97-8

1-(pyridine-3-carbonyl)pyrrolidine-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In dichloromethane at 0 - 25℃;100%
nicotinic acid
59-67-6

nicotinic acid

C21H33N3O
1619984-56-3

C21H33N3O

N-(((1S,2S,3R,8aS)-2,5,5,8a-tetramethyl-3-(nicotinamido)decahydronaphthalen-1-yl)methyl)nicotinamide
1619983-87-7

N-(((1S,2S,3R,8aS)-2,5,5,8a-tetramethyl-3-(nicotinamido)decahydronaphthalen-1-yl)methyl)nicotinamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h; Inert atmosphere;100%
nicotinic acid
59-67-6

nicotinic acid

1,1,1,3,3,3-hexamethyl-disilazane
999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

trimethylsilyl 3-pyridinecarboxylate
25436-37-7

trimethylsilyl 3-pyridinecarboxylate

Conditions
ConditionsYield
With ammonium bisulphate for 24h; Reflux; Inert atmosphere;100%
With ammonium sulfate In toluene at 95 - 110℃; Inert atmosphere;92%
With iodine In neat (no solvent) at 20℃; for 19h; Green chemistry;61%
nicotinic acid
59-67-6

nicotinic acid

cholin hydroxide
123-41-1

cholin hydroxide

2-hydroxy-N,N,N-trimethylethanaminium nicotinate
49719-80-4

2-hydroxy-N,N,N-trimethylethanaminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 9; Cooling with ice;100%
In water pH=7.66;
nicotinic acid
59-67-6

nicotinic acid

L-arginine
74-79-3

L-arginine

L-arginine nicotinate

L-arginine nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 6 - 6.2; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-histidine
71-00-1

L-histidine

(S)-1-carboxy-2-(1H-imidazol-4-yl)ethanaminium nicotinate

(S)-1-carboxy-2-(1H-imidazol-4-yl)ethanaminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 5.5 - 5.8; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-proline
147-85-3

L-proline

(S)-2-carboxypyrrolidin-1-ium nicotinate

(S)-2-carboxypyrrolidin-1-ium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-valine
72-18-4

L-valine

(S)-1-carboxy-2-methylpropan-1-aminium nicotinate

(S)-1-carboxy-2-methylpropan-1-aminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-Tryptophan
73-22-3

L-Tryptophan

(S)-1-carboxy-2-(1H-indol-3-yl)ethanaminium nicotinate

(S)-1-carboxy-2-(1H-indol-3-yl)ethanaminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice; Heating;100%
nicotinic acid
59-67-6

nicotinic acid

L-carnitine
541-15-1

L-carnitine

(R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium nicotinate

(R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-methionine
63-68-3

L-methionine

(S)-1-carboxy-3-(methylthio)propan-1-aminium nicotinate

(S)-1-carboxy-3-(methylthio)propan-1-aminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 2.8 - 3.3; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-isoleucine
73-32-5

L-isoleucine

(1S,2S)-1-carboxy-2-methylbutan-1-aminium nicotinate

(1S,2S)-1-carboxy-2-methylbutan-1-aminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 2.3 - 3.3; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

D-Val-OH
640-68-6

D-Val-OH

(R)-1-carboxy-2-methylpropan-1-aminium nicotinate

(R)-1-carboxy-2-methylpropan-1-aminium nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 3.3 - 3.9; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

N-butylamine
109-73-9

N-butylamine

C6H5NO2*C4H11N

C6H5NO2*C4H11N

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 7 - 7.2; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

ascorbic acid
50-81-7

ascorbic acid

niacin, ascorbic acid

niacin, ascorbic acid

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 2.8 - 3; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

L-glutamic acid
56-86-0

L-glutamic acid

L-glutamic acid nicotinate

L-glutamic acid nicotinate

Conditions
ConditionsYield
In water for 0.166667h; pH=Ca. 2.8 - 3.3; Cooling with ice;100%
nicotinic acid
59-67-6

nicotinic acid

oxalic acid
144-62-7

oxalic acid

nicotinic acid ; hydrogenoxalate
117883-08-6

nicotinic acid ; hydrogenoxalate

Conditions
ConditionsYield
at 120℃; under 0.450045 Torr; for 7h; Temperature;100%
nicotinic acid
59-67-6

nicotinic acid

Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

Conditions
ConditionsYield
With dihydrogen peroxide; molybdic acid In water at 92 - 95℃; for 3h; Green chemistry;99.6%
With dihydrogen peroxide In tetrahydrofuran; water for 5h; Reflux;91%
With hydrogen fluoride; 3-chloro-benzenecarboperoxoic acid In methanol; N,N-dimethyl-formamide at 25℃; for 3h;87%

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