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Cas Database

367274-58-6

367274-58-6

Identification

  • Product Name:5(4H)-Oxazolone, 4,4-dimethyl-2-(phenylmethoxy)-

  • CAS Number: 367274-58-6

  • EINECS:

  • Molecular Weight:219.24

  • Molecular Formula: C12H13NO3

  • HS Code:

  • Mol File:367274-58-6.mol

Synonyms:

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors

Nakajima, Katsumasa,April, Myriam,Brewer, Jason T.,Daniels, Thomas,Forster, Cornelia J.,Gilmore, Thomas A.,Jain, Monish,Kanter, Aaron,Kwak, Youngshin,Li, Jingzhou,McQuire, Les,Serrano-Wu, Michael H.,Streeper, Ryan,Szklennik, Paul,Thompson, James,Wang, Bing

, p. 1245 - 1248 (2016)

Diamide compounds were identified as potent DGAT1 inhibitors in vitro, but their poor molecular properties resulted in low oral bioavailability, both systemically and to DGAT1 in the enterocytes of the small intestine, resulting in a lack of efficacy in vivo. Replacing an N-alkyl group on the diamide with an N-aryl group was found to be an effective strategy to confer oral bioavailability and oral efficacy in this lipophilic diamide class of inhibitors.

Facile ring opening reaction of oxazolone enables efficient amidation for aminoisobutyric acid

Jo, Minmi,Won, Sun-Woo,Lee, Dong Guk,Yun, Jungeon,Kim, Sunhong,Kwak, Young-Shin

, p. 481 - 489 (2018/05/03)

Abstract: 4,4-Dimethyloxazolones derived from N-protected aminoisobutyric acid (AIB) are particularly known as poor electrophiles due to the steric hindrance around the carbonyl and not employed as useful intermediates for amidation whereas numerous examp

Linear oligopeptides. Part 329. Synthesis, characterization and solution conformational analysis of Cα-ethyl, Cα-benzylglycine containing peptides

Formaggio, Fernando,Pantano, Monica,Crisma, Marco,Bonora, Gian Maria,Toniolo, Claudio,Kamphuis, Johan

, p. 1097 - 1102 (2007/10/02)

For the first time a variety of derivatives and terminally blocked model peptides (to the pentapeptide level) of the sterically demanding (αEt)Phe residue have been synthesized (by solution methods) and fully characterized.The results of a solution conformational analysis, performed by using FTIR and 1H NMR spectroscopy, favour the conclusion that (αEt)Phe is a β-turn and helix promoter as strong as (αMe)Phe (Cα-methyl, Cα-benzylglycine) but more efficient than the Phe parent amino acid.In addition, a CD study of Nα-para-bromobenzoylated peptides suggests that the relationship between (αEt)Phe chirality and the screw sense of the turn and helical structures that are formed is the same as that found for (αMe)Phe peptides, i.e.L-amino acids give left-handed helicities.Interestingly, this relationship is opposite to that exhibited by protein amino acids, including Phe.

Process route upstream and downstream products

Process route

Z-Aib-OH
15030-72-5

Z-Aib-OH

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one
367274-58-6

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -72 ℃; Temperature;
90%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
41%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; for 1h;
Z-Aib-OH
15030-72-5

Z-Aib-OH

cyclohexylamine
108-91-8,157973-60-9

cyclohexylamine

[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester
101715-65-5

[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one
367274-58-6

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 - 80 ℃;
10%
80%
Z-Aib-OH
15030-72-5

Z-Aib-OH

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one
367274-58-6

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -72 ℃; Temperature;
90%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
41%
With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetonitrile; for 1h;
Z-Aib-OH
15030-72-5

Z-Aib-OH

cyclohexylamine
108-91-8,157973-60-9

cyclohexylamine

[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester
101715-65-5

[1-(cyclohexylmethyl-carbamoyl)-1-methylethyl]carbamic acid benzyl ester

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one
367274-58-6

2-(benzyloxy)-4,4-dimethyloxazol-5(4H)-one

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 - 80 ℃;
10%
80%

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