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Tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate is a chemical compound with the molecular formula C16H30N2O3. It is a derivative of piperidine, featuring a hydroxyl group attached to a piperidine ring. tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate is characterized by its unique structure and functional groups, which make it a valuable building block in pharmaceutical research and drug development. The presence of the tert-butyl group provides steric hindrance and stability, enhancing its utility in various synthetic applications within medicinal chemistry.

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  • 367500-88-7 Structure
  • Basic information

    1. Product Name: tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate
    2. Synonyms: tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate;4-Hydroxy-1,4'-bipiperidinyl-1'-carboxylic acid tert-butyl ester;tert-Butyl 4-(4-hydroxypiperidin-1-yl)-1-piperidinecarboxylate;tert-Butyl 4-hydroxy-[1,4'-bipiperidine]-1'-carboxylate;1-Boc-4-(4-hydroxypiperidin-1-yl)piperidine;tert-Butyl4-hydroxy-1,4'-bipiperidine-1'-carboxylate98%;1-Boc-[1,4]bipiperidinyl-4-ol
    3. CAS NO:367500-88-7
    4. Molecular Formula: C15H28N2O3
    5. Molecular Weight: 284.39442
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 367500-88-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.124
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate(367500-88-7)
    11. EPA Substance Registry System: tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate(367500-88-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 367500-88-7(Hazardous Substances Data)

367500-88-7 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate is utilized as a building block for the synthesis of various bioactive molecules. Its unique structure and functional groups make it potentially useful for the development of drugs targeting specific receptors or biological pathways, contributing to the advancement of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate is employed for its steric hindrance and stability provided by the tert-butyl group. This feature makes the compound suitable for a wide range of synthetic applications, facilitating the creation of new and effective pharmaceutical compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 367500-88-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,7,5,0 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 367500-88:
(8*3)+(7*6)+(6*7)+(5*5)+(4*0)+(3*0)+(2*8)+(1*8)=157
157 % 10 = 7
So 367500-88-7 is a valid CAS Registry Number.

367500-88-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-(4-hydroxypiperidin-1-yl)piperidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names 4-Hydroxy-1,4'-bipiperidinyl-1'-carboxylic acid tert-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:367500-88-7 SDS

367500-88-7Relevant articles and documents

3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS

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Paragraph 0322, (2021/04/23)

The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

Barton, Patrick,Brough, Steven,Evans, Richard,Luckhurst, Christopher A.,Mochel, Tobias,Perry, Matthew W. D.,Rigby, Aaron,Sanganee, Hitesh,Sisson, Adam,Springthorpe, Brian,Bahl, Ash,Bowers, Keith,Riley, Robert J.

, p. 6688 - 6693,6 (2012/12/12)

A series of dual CCR3/H1 antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to del

TRPV4 ANTAGONISTS

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Page/Page column 38, (2011/10/13)

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Chemical compounds

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, (2008/06/13)

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.

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