367497-18-5

Basic information

• Product Name: C₂₅H₂₈Cl₂N₂O₅
• CAS NO: 367497-18-5
• Molecular Weight: 507.414
• Mol File: 367497-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₈Cl₂N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₈Cl₂N₂O₅(367497-18-5)
• EPA Substance Registry System: C₂₅H₂₈Cl₂N₂O₅(367497-18-5)

Safety Data

• Hazardous Substances Data: 367497-18-5(Hazardous Substances Data)

Upstream product

• 367500-88-7 4-hydroxy-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 367500-72-9 4-(3,4-Dichloro-phenoxy)-[1,4']bipiperidinyl-1'-carboxylic acid tert-butyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1435-49-0 3,4-dichlorofluorobenzene 
• 95-77-2 3,4-dichlorophenol 
• 367500-74-1 4-(3,4-dichloro-phenoxy)-[1,4']bipiperidine 
• 1878-61-1 3-carboxyphenoxyacetic acid 
• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 
• 260441-48-3 tert-Butyl 4-(3,4-dichlorophenoxy)-1-piperidinecarboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Relevant articles and documents

The discovery of CCR3/H1 dual antagonists with reduced hERG risk

A series of dual CCR3/H1 antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to del