371925-11-0Relevant articles and documents
A new convenient four-component synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles and one-pot synthesis of 6′-amino-5′-cyano- 1,2-dihydrospiro- [(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2- ones
Litvinov,Rodinovskaya,Shestopalov
, p. 2362 - 2368 (2014/05/06)
A new convenient method for the synthesis of 6-amino-2H,4H-pyrano[2,3-c] pyrazole-5-carbonitriles, namely, four-component condensation of carbonyl compounds (aromatic aldehydes, heterocyclic ketones), malononitrile, ss-keto esters, and hydrazine hydrate in ethanol in the presence of triethylamine as a catalyst, which occurs selectively, is developed. One-pot two-step modification of this method is proposed for the synthesis of spiro[(3H)-indole-3,4′-(4′H)-pyrano[2,3-c]pyrazol]-2-ones.