437-81-0

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Difluorobenzaldehyde is used as a reactant for the synthesis of 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil, a compound with potential pharmaceutical applications. This synthesis is achieved through a one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
Used in Organic Synthesis:
In the field of organic synthesis, 2,6-Difluorobenzaldehyde serves as a reactant for the preparation of 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole. 2,6-Difluorobenzaldehyde is synthesized by reacting 2,6-difluorobenzaldehyde with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
Used in the Synthesis of (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one:
2,6-Difluorobenzaldehyde is also used in the Wittig olefination reaction to produce (3E)-4-(2,6-difluorophenyl)-3-buten-2-one. This reaction involves the use of acetylmethylidenetriphenyl phosphorane, resulting in the formation of a conjugated diene with potential applications in various chemical processes.
Used in the Preparation of Methyl 4-Fluorobenzo[b]thiophene-2-carboxylate:
Furthermore, 2,6-difluorobenzaldehyde is utilized in the synthesis of methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating it with methyl thioglycolate in the presence of K2CO3. This reaction leads to the formation of a heterocyclic compound with potential applications in various chemical and pharmaceutical industries.

InChI:InChI=1/C7H4F2O/c8-6-2-1-3-7(9)5(6)4-10/h1-4H

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 93-61-8 N-methyl-N-phenylformamide 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 2751-90-8 tetraphenylphosphonium bromide 
• 67-56-1 methanol 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 
• 19064-18-7 2,6-difluorobenzyl alcohol 
• 105-56-6 ethyl 2-cyanoacetate 
• 617-84-5 N-formyldiethylamine 
• 93343-10-3 3,5-difluoroanisol 
• 64-18-6 formic acid 
• 13697-89-7 2,6-difluoroiodobenzene 
• 443-84-5 2,6-difluorotoluene 

Downstream Products

• 120445-59-2 2,6-difluoro-benzaldehyde-semicarbazone 
• 385-00-2 2,6-difluorobenzoic acid 
• 1673-75-2 3-(2,6-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 124466-13-3 -(2,6-Difluoro-phenyl)-N,N'-bis-[1,3,4]thiadiazol-2-yl-methanediamine 
• 157224-28-7 1,3-Difluoro-2-((E)-2-nitro-propenyl)-benzene 
• 129749-87-7 5-(2',6'-difluorobenzylidene)-3-methylbarbituric acid 
• 129749-87-7 5-(2',6'-difluorobenzylidene)-3-methylbarbituric acid 
• 138226-12-7 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole 
• 177492-42-1 (1S,2S,4R,5R)-2,4-Bis-(2,6-difluoro-phenyl)-1,5-dimethyl-3-aza-bicyclo[3.3.1]nonan-9-one 
• 467442-18-8 2-(2,6-Difluoro-phenyl)-[1,3]dioxolane 
• 187585-25-7 Z-(2-chloro-2-nitroethenyl)-2,6-difluorobenzene 
• 104322-39-6 5,10,15,20-tetrakis(2′,6′-difluorophenyl)porphyrin 
• 186595-57-3 2-fluoro-6-(4-methylpiperazin-1-yl)benzaldehyde 
• 224294-28-4 3-(2,6-difluorophenyl)-1-(4-fluoro-2-hydroxyphenyl)-2-propen-1-one 

Relevant academic research and scientific papers

Latent Nucleophilic Carbenes

Using DFT and ab initio calculations, we demonstrate that noncyclic formamidines can undergo thermal rearrangement into their isomeric aminocarbenes under rather mild conditions. We synthesized the silylformamidine, for which the lowest activation energy in this process was predicted. Experimental studies proved it to serve as a very reactive nucleophilic carbene. The reactions with acetylenes, benzenes, and trifluoromethane proceeded via insertion into sp, sp2, and spCH bonds. The carbene also reacted with the functional groups, such as CHO, COR, and CN at double or triple bonds, displaying high mobility of the trimethylsilyl group. The obtained silylformamidine can be considered as a latent nucleophilic carbene. It can be prepared in bulk quantities, stored, and used when the need arises. Calculation results predict similar behavior for some other silylated formamidines and related compounds.

A Magnetically Recyclable Palladium-Catalyzed Formylation of Aryl Iodides with Formic Acid as CO Source: A Practical Access to Aromatic Aldehydes

A magnetically recyclable palladium-catalyzed formylation of aryl iodides under CO gas-free conditions has been developed by using a bidentate phosphine ligand-modified magnetic nanoparticles-anchored- palladium(II) complex [2P-Fe 3O 4@SiO 2-Pd(OAc) 2] as catalyst, yielding a wide variety of aromatic aldehydes in moderate to excellent yields. Here, formic acid was employed as both the CO source and the hydrogen donor with iodine and PPh 3as the activators. This immobilized palladium catalyst can be obtained via a simple preparative procedure and can be facilely recovered simply by using an external magnetic field, and reused at least 9 times without any apparent loss of catalytic activity.

Method for efficiently synthesizing fluorine-containing compound

The invention discloses a method for efficiently synthesizing a fluorine-containing compound, and relates to the field of fluorine-containing compound synthesis. The method is a method for generating a corresponding fluorine atom substituted fluorine-containing compound by reacting aromatic chloride or activated chloride serving as a raw material with potassium fluoride under the action of a novel catalyst. The method disclosed by the invention has the advantages of good product selectivity, high efficiency, mild reaction conditions, simplicity and convenience in operation, convenience in application and the like.

Synthesis of 2, 6 - difluoro phenyl -1 - (4, 5 - [...]) -3 - ketone to make a new method

The invention discloses a method for synthesizing 2, 6 - difluoro phenyl - 1 - (4, 5 - [...]) - 3 - ethyl ketone of the new method. This synthetic route avoids the synthetic intermediate 1, 3 - difluoro - 2 - steps of styrene, overcome prior art intermediate volatile not easy to store, and due to the synthetic process needs to be used sodium hydride synthesis of operation and great danger of defect, so that the synthesis process is more suitable for large-scale production; the synthetic route higher yield, and the final target 2, 6 - difluoro phenyl - 1 - (4, 5 - [...]) - 3 - ethyl ketone through re-crystallization mode is purified, high purity 98%; and this synthetic route uses the raw materials of the commercial production of the raw material, cheap and easy to obtain.

Pd-Catalyzed, ortho C-H Methylation and Fluorination of Benzaldehydes Using Orthanilic Acids as Transient Directing Groups

The direct, Pd-catalyzed ortho C-H methylation and fluorination of benzaldehydes have been accomplished using commercially available orthanilic acids as transient directing groups. In these reactions, the 1-fluoro-2,4,6-trimethylpyridinium salts can be either a bystanding F+ oxidant or an electrophilic fluorinating reagent. An X-ray crystal structure of a benzaldehyde ortho C-H palladation intermediate was obtained using triphenylphosphine as the stabilizing ligand.

Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation

An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi

A 2, 6 - difluoro toluene of continuous oxidation to prepare 2, 6 - difluorobenzaldehyde method (by machine translation)

The invention relates to a 2, 6 - difluoro toluene of continuous oxidation to prepare 2, 6 - difluorobenzaldehyde method, which belongs to the technical field of organic synthesis process. The method is to 2, 6 - difluoro toluene compound as a raw materia

DIRECT DYES AND COMPOSITION COMPRISING THE DYES

The present invention relates to novel direct dyes and compositions comprising them for dyeing keratin fibers especially human hair. The novel dyes of the present invention have benzothiophene structure providing intensive and homogeneous dyeing on kerati

Polyoxometalate-Intercalated Layered Double Hydroxides as Efficient and Recyclable Bifunctional Catalysts for Cascade Reactions

The polyoxometalate (POM) intercalated layered double hydroxides (LDHs) have been widely used as heterogeneous catalysts. However, the application of POM-LDHs as bifunctional catalysts for cascade reaction has seldom been studied compared to the noble-metal-based catalysts. Herein, a series of POM-LDHs catalysts of Tris-LDH-X4(PW9)2 (X=Mn, Fe, Co, Ni, Cu, and Zn; Tris=Tris(hydroxymethtyl)aminomethane) have been prepared. The efficacy of Tris-LDH-Zn4(PW9)2 as efficient bifunctional catalyst has been demonstrated for cascade reactions involving oxidation of benzyl alcohol to benzaldehyde followed by Knoevenagel condensation with ethyl cyanoacetate to produce benzylidene ethyl cyanoacetate. The combination of POM's redox/acidic sites and LDHs's basic sites led to a composite catalyst with excellent activity (99 %) and selectivity (≥99 %) under mild and soluble-base-free conditions. This work offers a new design strategy for the fabrication of efficient bifunctional catalysts for the promotion of one-pot cascade reactions.

METHOD OF PRODUCING BENZENE COMPOUND

PROBLEM TO BE SOLVED: To provide a new production method for the benzene compound represented by formula (2). SOLUTION: The present invention provides a production method for the benzene compound represented by formula (2), the method including mixing of a compound represented by formula (1) and dimethyl sulfoxide (where R1, R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a fluorinated alkyl group, a hydroxyl group, an alkoxy group, an aryl group or a nitro group). COPYRIGHT: (C)2016,JPOandINPIT