3720-97-6

Basic information

• Product Name: 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE
• Synonyms: 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE;4,5-dihydroxyimidazolidin-2-one;4,5-Dihydroxy-2-imidazolidone
• CAS NO: 3720-97-6
• Molecular Formula: C3H6N2O3
• Molecular Weight: 118.09
• EINECS: 223-070-6
• Mol File: 3720-97-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 157-160°C
• Boiling Point: 531.5°Cat760mmHg
• Flash Point: 275.3°C
• Appearance: /
• Density: 1.657g/cm³
• Vapor Pressure: 1.62E-13mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 12.13±0.60(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE(3720-97-6)
• EPA Substance Registry System: 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE(3720-97-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3720-97-6(Hazardous Substances Data)

Usage

Description

4,5-Dihydroxytetrahydro-2H-imidazol-2-one, a heterocyclic compound with the molecular formula C4H6N2O3, is characterized by a 2,5-dihydro-1H-imidazol-2-one core with hydroxyl groups at the 4 and 5 positions. It is a product of the reaction between nitric oxide and uric acid, occurring naturally in human saliva and other biological fluids. 4,5-DIHYDROXYTETRAHYDRO-2H-IMIDAZOL-2-ONE has demonstrated potential antioxidant and anti-inflammatory properties and is believed to contribute to the regulation of physiological processes within the body. Further research is essential to uncover its full spectrum of biological activities and possible applications.

Uses

Used in Pharmaceutical Industry:
4,5-Dihydroxytetrahydro-2H-imidazol-2-one is used as a potential therapeutic agent for its antioxidant and anti-inflammatory properties. Its role in modulating physiological processes suggests that it could be beneficial in treating conditions associated with oxidative stress and inflammation.
Used in Research Applications:
In the field of scientific research, 4,5-Dihydroxytetrahydro-2H-imidazol-2-one serves as a valuable compound for studying the biochemical pathways and mechanisms involving nitric oxide and uric acid interactions. It aids in understanding the broader implications of these interactions in human health and disease.
Used in Nutraceutical Development:
Given its presence in biological fluids and potential health benefits, 4,5-Dihydroxytetrahydro-2H-imidazol-2-one may be utilized in the development of nutraceutical products aimed at promoting overall health and well-being by supporting the body's natural antioxidant and anti-inflammatory defenses.
Used in Cosmetics Industry:
The antioxidant properties of 4,5-Dihydroxytetrahydro-2H-imidazol-2-one could make it a candidate for use in cosmetics, particularly in anti-aging formulations, where it may help protect the skin from oxidative damage and promote a more youthful appearance.

InChI:InChI=1/C3H6N2O3/c6-1-2(7)5-3(8)4-1/h1-2,6-7H,(H2,4,5,8)/t1-,2-/m1/s1

Upstream product

• 131543-46-9 Glyoxal 
• 57-13-6 urea 
• 107292-24-0 trans-4,5-Dihydroperoxyimidazolidin-2-one 

Downstream Products

• 496-46-8 glycouril 
• 3721-04-8 (3aR,6aS)-1-Benzyl-tetrahydro-imidazo[4,5-d]imidazole-2,5-dione 
• 1854-26-8 dimethyloldihydroxyethylene urea 
• 496-46-8 glycoluril 
• 461-72-3 2,4-imidazolidinedione 
• 436811-14-2 (-)-(S)-2-[(1S,5R)-(3,7-dioxo-2,4,6,8-tetraazabicyclo[3.3.0]oct-2-yl)]-4-(methylthio)butanoic acid 

Relevant articles and documents

Anion-free bambus[6]uril and its supramolecular properties

Methods for the preparation of anion-free bambus[6]uril (BU6) are presented. They are based on the oxidation of iodide anion, which is bound inside the macrocycle, utilizing dark oxidation by hydrogen peroxide or photooxidation in the presence of titanium dioxide. Anion-free BU6 was found to be insoluble in any of the investigated solvents; however, it dissolves in methanol/chloroform (1:1) or acetonitrile/water (1:1) mixtures in the presence of the tetrabutylammonium salt of a suitable anion. The association constants with halide ions, BF4-, NO3-, and CN-, were measured by 1H NMR spectroscopy. The highest association constant (8.9×105 M-1) was found for the 1:1 complex of BU6 with I- in acetonitrile/water mixture. A number of crystal structures of BU6 complexes with various anions were obtained. The influence of the anion size on the macrocycle diameter is discussed together with an unusual arrangement of the macrocycles into separate layers.

Dihydroxy methyl dihydroxy ethene carbamide improved preparation method

The invention provides a preparation method of dimethylol dihydroxy ethylene urea. The method comprises the following steps: 1, reacting urea with glyoxal in the presence of sulfonic acid and sulfonic acid alkali metal salt at 30-60DEG C for 3-6h to prepare a dihydroxy ethylene urea intermediate; and 2, reacting the dihydroxy ethylene urea intermediate obtained in step 1 with a formaldehyde and optional organic alcohol amine mixture in the presence of dialkali metal hydrogen phosphate and alkali metal dihydrogen phosphate at 40-60DEG C for 2-4h to obtain a target product. The preparation method has the advantages of stable reaction and high conversion rate, and the product has the advantages of high content of active groups, and strong responsivity.

Easy Synthesis of trans -4,5-Dihydroxy-2-imidazolidinone and 2,4-Dimethylglycoluril

A simple and efficient synthesis of 2,4-dimethylglycoluril involving the formation of trans-4,5-dihydroxy-2-imidazolidinone is presented as well as a reproducible protocol to reduce contamination with its decomposition products, identified as urea and 1,3-dimethylimidazolidine-2,4-dione.