375856-23-8

Basic information

• Product Name: 3-Buten-2-one, 4-ethoxy-1,1-difluoro-
• Synonyms: 3-Buten-2-one, 4-ethoxy-1,1-difluoro-
• CAS NO: 375856-23-8
• Molecular Formula: C6H8F2O2
• Molecular Weight: 150.12
• Mol File: 375856-23-8.mol

Chemical Properties

• Boiling Point: 147.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.104±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-Buten-2-one, 4-ethoxy-1,1-difluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-ethoxy-1,1-difluoro-(375856-23-8)
• EPA Substance Registry System: 3-Buten-2-one, 4-ethoxy-1,1-difluoro-(375856-23-8)

Safety Data

• Hazardous Substances Data: 375856-23-8(Hazardous Substances Data)

Upstream product

• 381-72-6 difluoroacetyl chloride 
• 109-92-2 ethyl vinyl ether 
• 401-67-2 2,2-difluoroacetic anhydride 

Downstream Products

• 1007468-17-8 3-(difluoromethyl)-1H-pyrazole 
• 1609552-46-6 C₁₃H₁₆F₂N₂O₂ 
• 1261885-09-9 4-(difluoromethyl)-2-phenylpyrimidine 

Relevant articles and documents

4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase

The treatment of epidermal growth factor receptor (EGFR)-driven non-small cell lung cancers with the T790M resistance mutation remains a significant unmet medical need. We report the identification of 4-aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of EGFR, with excellent activity against the T790M resistance double mutants and initial single activating mutants. Using an optimization strategy focused on structure-based design and improving PK properties through metabolite identification, we obtained advanced leads with high oral exposure.

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

A series of novel oxazolidinone derivatives bearing fluoroalkyl-substituted pyrazole as the C-ring structure were designed, synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most of the target compounds have good antibacterial activity. Especially, compounds 13f, 13i and 13l show excellent activity comparable to linezolid.

Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

A series of pyridine derivatives in the C-region of N-((6-trifluoromethyl-pyridin-3-yl)methyl) 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. The SAR analysis indicated that 6-difluorochloromethyl pyridine derivatives were the best surrogates of the C-region for previous leads. Among them, compound 31 showed excellent antagonism to capsaicin as well as to multiple hTRPV1 activators. It demonstrated stronganalgesic activity in the formalin test in mice with full efficacy and it blocked capsaicin-induced hypothermia in vivo.

Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides

The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.