375857-62-8

Basic information

• Product Name: 3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIMIDINE
• Synonyms: 3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIMIDINE
• CAS NO: 375857-62-8
• Molecular Formula: C₇H₆BrN₃
• Molecular Weight: 212.05
• Mol File: 375857-62-8.mol

Chemical Properties

• Appearance: /
• Density: 1.76g/cm³
• Refractive Index: 1.714
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.18±0.30(Predicted)
• CAS DataBase Reference: 3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIMIDINE(375857-62-8)
• EPA Substance Registry System: 3-BROMO-7-METHYLIMIDAZO[1,2-A]PYRIMIDINE(375857-62-8)

Safety Data

• Hazardous Substances Data: 375857-62-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
3-Bromo-7-methylimidazo[1,2-a]pyrimidine is used as a pharmaceutical drug candidate for its potential biological activities and therapeutic effects. Its unique chemical structure makes it a subject of interest for researchers exploring its role in the development of new medications.
Used in Organic Synthesis:
In the Chemical Industry, 3-Bromo-7-methylimidazo[1,2-a]pyrimidine is used as a building block in the synthesis of other organic compounds. Its versatile structure allows it to be a valuable component in creating various compounds for different scientific and industrial applications.

InChI:InChI=1/C7H6BrN3/c1-5-2-3-11-6(8)4-9-7(11)10-5/h2-4H,1H3

Upstream product

• 6558-66-3 7-methylimidazo[1,2-a]pyrimidine 
• 17412-28-1 7-methyl-imidazo[1,2-b]pyridazine 

Relevant articles and documents

Discovery of imidazo[1,2-b][1,2,4]triazines as GABAA α2/3 subtype selective agonists for the treatment of anxiety

The identification of a series of imidazo[1,2-b][1,2,4]triazines with high affinity and functional selectivity for the GABAA α3-containing receptor subtype is described, leading to the identification of a clinical candidate, 11. Compound 11 shows good bioavailability and half-life in preclinical species, and it is a nonsedating anxiolytic in both rat and squirrel monkey behavioral models.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.