37591-27-8Relevant articles and documents
NOVEL TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
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Page/Page column 69-70, (2009/06/27)
The present invention relates to novel tricyclic derivatives having an excellent inhibitory activity on poly (ADP-ribose) polymerase, or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The tricyclic derivatives of the present invention inhibit the activity of poly (ADP-ribose) polymerase, thereby being used for the prevention or treatment of diseases that are caused by excessive activation of PARP, in particular, neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic neuropathic pain, inflammatory diseases, osteoporosis, and cancer.
Seven-Membered Rings by 1,5-Cycloadditions, VI. - 7-Aminoperhydro-1,4-oxazepines and -diazepines
Griengl, Herfried,Prischl, Gerhard,Bleikolm, Anton
, p. 1573 - 1582 (2007/10/02)
3-Alkyl-1,3-oxazolidines 2 react with enamines 1 in the presence of trifluoroacetic acid to give 7-dialkylaminoperhydro-1,4-oxazepines 3. 1,3-Dimethyl-1,3-imidazolidine (2d) reacts with 4-(2-methyl-1-propenyl)morpholine (1a) to give 1,4,6,6-tetramethyl-7-morpholino-2,3,4,5,6,7-hexahydro-1H-1,4-diazepine (3m).