38465-00-8Relevant articles and documents
Direct preparation of primary amides by reaction of carboxylic acids and ammonia in alcohols using DMT-MM
Mizuhara, Tsukasa,Hioki, Kazuhito,Yamada, Megumi,Sasaki, Hideaki,Morisaki, Daiki,Kunishima, Munetaka
, p. 1191 - 1192 (2008)
A simple and mild method for the direct conversion of carboxylic acids to primary amides has been developed by using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)- 4-methylmorpholim'um chloride (DMT-MM). The reaction proceeds by adding DMT-MM to a mixture of carboxylic acids and an ammonia source in methanol, 2-propanol, or THF without any additives. The present method is quite practical in that aqueous ammonia or ammonium chloride/triethylarnine can be used as an ammonia source. Methanol or 2-propanol is an ideal polar solvent because it is inexpensive, can be removed by rotary evaporator, and solubilizes many kinds of polar or nonpolar compounds.
Corresponding amine nitrile and method of manufacturing thereof
-
Paragraph 0124; 0125; 0131, (2018/05/24)
The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.
Corresponding amine nitrile and method of manufacturing thereof (by machine translation)
-
Paragraph 0124; 0125; 0126; 0131, (2018/07/15)
The present invention relates to a nitrile manufacturing method, which has characteristics of significantly-reduced ammonia source consumption, low environmental pressure, low energy consumption, low production cost, high nitrile purity, high nitrile yield and the like compared with the method in the prior art, wherein nitrile having a complicated structure can be obtained through the method. The present invention further relates to a method for producing a corresponding amine from the nitrile.
Corresponding amine nitrile and method of manufacturing thereof
-
Paragraph 0125; 0126; 0131; 0132, (2018/07/15)
The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.