391-77-5

Basic information

• Product Name: 4-Chloro-6-fluoroquinoline
• Synonyms: BUTTPARK 20\09-07;4-CHLORO-6-FLUOROQUINOLINE;EOS-62017;4-CHLORO-6-FLUOROQUINOLINE(WX900022)
• CAS NO: 391-77-5
• Molecular Formula: C₉H₅ClFN
• Molecular Weight: 181.59
• Product Categories: Quinoline&Isoquinoline
• Mol File: 391-77-5.mol

Chemical Properties

• Melting Point: 75.0 to 79.0 °C
• Boiling Point: 259.944 °C at 760 mmHg
• Flash Point: 111.011 °C
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: 2-8°C
• PKA: 2.90±0.16(Predicted)
• CAS DataBase Reference: 4-Chloro-6-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-fluoroquinoline(391-77-5)
• EPA Substance Registry System: 4-Chloro-6-fluoroquinoline(391-77-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41-37/38
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 391-77-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-6-fluoroquinoline is used as an intermediate in the synthesis of pharmaceutical compounds for its potential medicinal properties. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting bacterial infections or other therapeutic areas where quinolines have demonstrated efficacy.
Used in Dye Production:
In the dye industry, 4-Chloro-6-fluoroquinoline is utilized as a precursor or intermediate in the production of various dyes. Its chemical structure contributes to the color and stability of the dyes, making it a valuable component in creating a wide range of colorants for different applications.
Used in Chemical Synthesis:
4-Chloro-6-fluoroquinoline serves as a building block in the synthesis of other complex organic compounds. Its reactivity and structural features make it a versatile starting material for creating a variety of chemical products, including advanced materials, agrochemicals, and specialty chemicals.

InChI:InChI=1/C9H5ClFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H

Upstream product

• 391-78-6 6-Fluoro-4-hydroxyquinoline 
• 343-10-2 6-fluoro-4-hydroxy-quinoline-3-carboxylic acid 
• 318-35-4 ethyl 6-fluoro-4-hydroxy-3-quinoline-carboxylate 
• 26832-96-2 diethyl 2-(4-fluoroanilino)methylenemalonate 
• 371-40-4 4-fluoroaniline 
• 38470-26-7 6-fluoro-2,3-dihydroquinolin-4(1H)-one 

Downstream Products

• 178990-45-9 4-chloro-6-fluoro-2-(2-hydroxyphenyl)quinoline 
• 103914-13-2 1-[2-(4-chlorophenyl)-6-fluoro-4-quinolinyl]-4-piperidinecarboxamide 
• 178990-50-6 1-[2-(2-hydroxyphenyl)-6-fluoro-4-quinolinyl]-4-piperidinecarboxamide 
• 178990-49-3 1-[6-fluoro-2-(2-methoxyphenyl)-4-quinolinyl]-4-piperidinecarboxamide 
• 282100-04-3 (2S)-2-[benzyl[(2R)-2-(4-benzyloxy-3-nitrophenyl)-2-hydroxyethyl]amino]-3-[4-(6-fluoroquinolin-4-yloxy)phenyl]propan-1-ol 
• 103914-50-7 4-chloro-6-fluoro-2-(4-fluorophenyl)quinoline 

Relevant articles and documents

Preparation method of 4-chloro-6-fluoroquinoline

The invention discloses a preparation method of 4-chloro-6-fluoroquinoline. The preparation method comprises the steps: with fluoroaniline as a starting material, firstly, carrying out Michael addition reaction with acrylic acid to obtain an intermediate 3-(4-fluoroanilino)propionic acid; followed by, carrying out a condensation cyclization reaction to obtain an intermediate 6-fluoro-2,3-dihydroquinoline-4(1H)-one; and finally, carrying out halogenation and dehydrogenation reaction to obtain 4-chloro-6-fluoroquinoline. The preparation method has the advantages of wide raw material sources and relatively low cost, thereby having relatively low production cost; at the same time, the preparation method has the advantages of relatively short synthesis route and relatively high yield, especially has mild reaction conditions, has no need of special high temperature equipment, and is suitable for industrialized mass production.

4-Piperidino-2-phenylquinolines

Disclosed are compounds of the formula STR1 wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.

7-Hydroxy-benzo[ij]quinolizine-2-carboxylic acids, intermediates, and a method for their production

Intermediates for and a process for preparing certain substituted 6,7-dihydro-7-hydroxy-1-oxo-1H,5H-benzo[ij]quinolizine carboxylic acids is described. The end products are useful antibacterial agents.

7-Hydroxy-benzo[ij]quinolizine-2-carboxylic acids and derivatives thereof

Certain substituted 6,7-dihydro-7-hydroxy-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids and salt and ester derivatives thereof are described. These compounds are useful antibacterial agents.