39633-00-6Relevant articles and documents
The synthesis of 7-substituted-2, 3-dihydropyrido [4, 3-d]pyridazine-1, 4-diones and 1, 4-Dioxo-7-substituted-1, 2, 3, 4-tetrahydropyrido[4, 3-d]pyridazine 6-oxides from methyl ketones
Prek, Benjamin,Stanovnik, Branko
, p. 798 - 803 (2018/01/17)
A general four-step transformation of alkyl, cycloalkyl, aryl, and heteroaryl methyl ketones via 3-(dimethylamino)-1-substituted-prop-2-en-1-ones, followed by microwave [2+2] cycloaddition of dimethyl acetylenedicarboxylate, cyclization of (2E, 3E)-2-[(dimethylamino)methylene]-3-(2-substituted)succinates with ammonia or hydroxylamine hydrochloride into 2-substituted-pyridine-4, 5-dicarboxylates and their N-oxides and final cyclization with hydrazine hydrate into of 7-substituted-2, 3-dihydropyrido[3, 4-d]pyridazine-1, 4-diones and 1, 4-dioxo-7-substituted-1, 2, 3, 4-tetrahydropyrido[ 4, 3-d]pyridazine 6-oxides is shown.
Novel pyridine-formation reactions of 2-(phosphoranylideneamino)acrylaldehydes with acetylenic esters. Synthesis of 2-mono-and 2,5-disubstituted nicotinates
Kanomata, Nobuhiro,Nakata, Tadashi
, p. 2551 - 2558 (2007/10/03)
Preparation of 2-(phosphoranylideneamino)acrylaldehydes, novel formyl-substituted (vinylimino)phosphoranes, was accomplished by the reaction of formyl-2H-azirines with triphenylphosphine. Their novel pyridine-formation reactions with acetylenic esters ach
HEXACARBONYLMOLYBDENIUM-INDUCED FORMATION OF PYRIDINES FROM ISOXAZOLES AND ACETYLENIC ESTER
Kobayashi, Tomoshige,Nitta, Makoto
, p. 1233 - 1236 (2007/10/02)
Upon treatment with Mo(CO)6 in anhydrous benzene, substituted isoxazoles undergo a novel inclusion of dimethyl acetylenedicarboxylate across the C4-C5 bond and loss of an oxygen atom to lead to pyridines.