3964-57-6

Basic information

• Product Name: METHYL 3-CHLORO-4-HYDROXYBENZOATE
• Synonyms: 4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER;3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER;METHYL 3-CHLORO-4-HYDROXYBENZOATE;METHYL-4-HYDROXY-3-CHLOROBENZOATE;RARECHEM AL BF 0232;4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER 97%;3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER 97%
• CAS NO: 3964-57-6
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• EINECS: 223-573-0
• Product Categories: Aromatic Esters
• Mol File: 3964-57-6.mol

Chemical Properties

• Melting Point: 108-110°C
• Boiling Point: 284.9 °C at 760 mmHg
• Flash Point: 126.1 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 0.00168mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.89±0.18(Predicted)
• BRN: 2641291
• CAS DataBase Reference: METHYL 3-CHLORO-4-HYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-CHLORO-4-HYDROXYBENZOATE(3964-57-6)
• EPA Substance Registry System: METHYL 3-CHLORO-4-HYDROXYBENZOATE(3964-57-6)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: 22-24/25
• Hazardous Substances Data: 3964-57-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-CHLORO-4-HYDROXYBENZOATE is used as a reagent for the preparation of alkylidene hydrazides, which are human glucagon receptor antagonists. These antagonists play a crucial role in the treatment of hyperglycemia and diabetes by modulating the body's blood sugar levels and improving insulin sensitivity.
Application type: Reagent
Application reason: Preparation of alkylidene hydrazides for the treatment of hyperglycemia and diabetes.

InChI:InChI=1/C8H7ClO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 3964-58-7 3-chloro-4-hydroxybenzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 

Downstream Products

• 98405-97-1 methyl 3-chloro-4-(β-methoxyethoxymethyl)oxybenzoate 
• 105960-29-0 2-chloro-4-(hydroxymethyl)phenol 
• 205106-54-3 4-(2-bromo-ethoxy)-3-chloro-benzoic acid methyl ester 
• 219680-33-8 3-Chloro-4-hydroxybenzoic Acid (4-Hydroxy-1-naphthylmethylene)hydrazide 
• 700832-69-5 3-(3-chloro-4-hydroxyphenyl)-3-pentanol 
• 570408-03-6 4-(1-tert-butoxy-2-propoxy)-3-chlorobenzoic acid methyl ester 
• 570407-91-9 4-[2-(tert-butyldimethylsilyloxy)ethoxy]-3-chlorobenzoic acid methyl ester 
• 864178-59-6 3-chloro-4-(2,2,2-trifluoro-ethoxy)-benzoic acid methyl ester 
• 213598-06-2 methyl 3-chloro-4-isopropoxybenzoate 
• 148452-73-7 3-Chloro-4-(tetradecyloxy)benzoic acid methyl ester 
• 161921-81-9 methyl 3-chloro-4-hydroxy-5-(prop-2-ene-1-yl)benzoate 
• 155884-04-1 3-chloro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester 
• 123014-86-8 3-chloro-4-[6-[2,3-bis(phenylmethoxy)phenyl]hexyloxy]benzoic acid methyl ester 
• 37908-98-8 methyl 3-chloro-p-anisate 

Relevant articles and documents

A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids

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NOVEL INHIBITORS OF MAP4K1

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Hydrazide-hydrazones have gained great importance due to their diverse biological properties, including anti-inflammatory, antimalarial and antituberculotic activities. With the aim of obtaining novel hydrazide-hydrazones with a wide spectrum of pharmaceutical applications, herein is reported the synthesis and antibacterial activity of a series of fifteen new hydrazide-hydrazones derivatives synthesized from coupling of methyl-3-chloro-4-hydroxybenzoate and 3-chloro-benzylchloride 3. The newly synthesized fifteen hydrazone derivatives 6a-o have been screened against four chosen bacterial strains viz., E. coli, P. aeruginosa, S. aureus and S. pyogenes with ampicillin as the standard drug. It is observed that compounds 6m (2,4-di-fluoro), 6n (3,4-di-fluoro) and 6o (2-methyl-4-fluro) exhibit excellent antibacterial activity (zone of inhibition 21-24 mm), while compounds 6j, 6k, 6l having 4-CF3, 4-OCF3 and 2-CF3 substituents display equipotent antibacterial activity (zone of inhibition 19-22 mm).

Multicomponent multicatalyst reactions (MC)2R: One-pot synthesis of 3,4-dihydroquinolinones

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AMINO ACID COMPOUNDS

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