3964-57-6

Basic information

• Product Name: METHYL 3-CHLORO-4-HYDROXYBENZOATE
• Synonyms: 4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER;3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER;METHYL 3-CHLORO-4-HYDROXYBENZOATE;METHYL-4-HYDROXY-3-CHLOROBENZOATE;RARECHEM AL BF 0232;4-HYDROXY-3-CHLOROBENZOIC ACID METHYL ESTER 97%;3-CHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER 97%
• CAS NO: 3964-57-6
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• EINECS: 223-573-0
• Product Categories: Aromatic Esters
• Mol File: 3964-57-6.mol

Chemical Properties

• Melting Point: 108-110°C
• Boiling Point: 284.9 °C at 760 mmHg
• Flash Point: 126.1 °C
• Appearance: /
• Density: 1.354 g/cm³
• Vapor Pressure: 0.00168mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.89±0.18(Predicted)
• BRN: 2641291
• CAS DataBase Reference: METHYL 3-CHLORO-4-HYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-CHLORO-4-HYDROXYBENZOATE(3964-57-6)
• EPA Substance Registry System: METHYL 3-CHLORO-4-HYDROXYBENZOATE(3964-57-6)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: 22-24/25
• Hazardous Substances Data: 3964-57-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-CHLORO-4-HYDROXYBENZOATE is used as a reagent for the preparation of alkylidene hydrazides, which are human glucagon receptor antagonists. These antagonists play a crucial role in the treatment of hyperglycemia and diabetes by modulating the body's blood sugar levels and improving insulin sensitivity.
Application type: Reagent
Application reason: Preparation of alkylidene hydrazides for the treatment of hyperglycemia and diabetes.

InChI:InChI=1/C8H7ClO3/c1-12-8(11)5-2-3-7(10)6(9)4-5/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 3964-58-7 3-chloro-4-hydroxybenzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 

Downstream Products

• 3964-58-7 3-chloro-4-hydroxybenzoic acid 
• 192512-43-9 4-ethoxy-3-chloro-benzoic acid methyl ester 
• 98405-97-1 methyl 3-chloro-4-(β-methoxyethoxymethyl)oxybenzoate 
• 105960-29-0 2-chloro-4-(hydroxymethyl)phenol 
• 39634-98-5 3-chloro-4-hydroxybenzoic acid hydrazide 
• 923584-42-3 methyl 3-chloro-4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate 
• 905303-82-4 acetic acid 2-chloro-4-isocyanato-phenyl ester 
• 905303-79-9 3-chloro-4-hydroxy-benzoyl azide 
• 905303-81-3 acetic acid 4-azidocarbonyl-2-chloro-phenyl ester 
• 905303-84-6 acetic acid 2-chloro-4-(3,3-dimethyl-ureido)-phenyl ester 
• 34637-13-3 N,N-dimethyl-N'-(3-chloro-4-hydroxy-phenyl)-urea 

Relevant articles and documents

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