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CAS

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3964-81-6

Azatadine Maleate is a pharmaceutical compound belonging to the class of antihistamines. It is characterized by its benzo[5,6]cyclohepta[1,2-b]pyridine structure with a 1-methylpiperidin-4-ylidene group at the 11-position. AzatadineMaleate is known for its antihistaminic properties and is used to alleviate symptoms associated with allergies.
Source:
Azatadine Maleate is synthesized through a series of chemical reactions involving the appropriate precursors and reagents. The exact method of synthesis may vary depending on the specific requirements of the pharmaceutical industry.
Production Methods:
The production of Azatadine Maleate typically involves a series of chemical reactions, including the formation of the benzo[5,6]cyclohepta[1,2-b]pyridine core, followed by the introduction of the 1-methylpiperidin-4-ylidene group at the 11-position. The process may also involve the formation of the maleate salt to improve the compound's solubility and stability.

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  • 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine Manufacturer/High quality/Best price/In stock

    Cas No: 3964-81-6

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  • 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

    Cas No: 3964-81-6

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  • 3964-81-6 Structure

  • Basic information

    1. Product Name: AzatadineMaleate
    2. Synonyms: 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-methylpiperidin-4-ylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine;5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 6,11-dihydro-11-(1-Methyl-4-piperidinylidene)-
    3. CAS NO:3964-81-6
    4. Molecular Formula: C20H22N2
    5. Molecular Weight: 290.4
    6. EINECS: 223-615-8
    7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 3964-81-6.mol

  • Chemical Properties

    1. Melting Point: 124-126°
    2. Boiling Point: 450.1 °C at 760 mmHg
    3. Flash Point: 226 °C
    4. Appearance: White or off-white crystalline powder
    5. Density: 1.127
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 8.74±0.20(Predicted)
    10. CAS DataBase Reference: AzatadineMaleate(CAS DataBase Reference)
    11. NIST Chemistry Reference: AzatadineMaleate(3964-81-6)
    12. EPA Substance Registry System: AzatadineMaleate(3964-81-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3964-81-6(Hazardous Substances Data)

3964-81-6 Usage

Uses

Used in Pharmaceutical Industry:
Azatadine Maleate is used as an antihistaminic agent for the treatment of various allergic conditions, such as allergic rhinitis, chronic urticaria, and atopic dermatitis. It works by blocking the action of histamine, a substance released by the body during an allergic reaction, which causes symptoms like itching, redness, and swelling.
Used in Allergy Medication:
Azatadine Maleate is used as an active ingredient in allergy medications, such as the brand name Optimine (Schering). It helps to relieve symptoms like sneezing, runny nose, and itchy eyes associated with allergic reactions by inhibiting the histamine receptors.

Check Digit Verification of cas no

The CAS Registry Mumber 3964-81-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,9,6 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 3964-81:
(6*3)+(5*9)+(4*6)+(3*4)+(2*8)+(1*1)=116
116 % 10 = 6
So 3964-81-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2.2C4H4O4/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19;2*5-3(6)1-2-4(7)8/h2-7,12,16,19H,8-11,13-14H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

3964-81-6Relevant articles and documents

Preparation method of loratadine impurity

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Paragraph 0029-0052, (2020/03/14)

The invention provides a preparation method of a loratadine impurity. The method comprises the following steps: dissolving methylloratadine in a solvent, adding an acid and a catalyst into the solution, heating the solution in a hydrogen atmosphere for a heating reaction, and carrying out cooling, filtering, concentrating and purifying to obtain the loratadine impurity represented by the formula II. According to the technical scheme, the raw materials are cheap and easily available, the operation and post-treatment are simple, the reaction conditions are mild, the process is stable, the yieldis high, and the reproducibility is good. According to the technical scheme, the blank that no loratadine impurity preparation method exists in China is filled up, the cost of developing the medicineby pharmaceutical enterprises can be reduced, and the preparation method has a very good industrial application prospect.

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