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CAS

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401891-53-0

2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 401891-53-0 Structure

  • Basic information

    1. Product Name: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide
    2. Synonyms: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide
    3. CAS NO:401891-53-0
    4. Molecular Formula:
    5. Molecular Weight: 535.316
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 401891-53-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide(401891-53-0)
    11. EPA Substance Registry System: 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-chloro-4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide(401891-53-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 401891-53-0(Hazardous Substances Data)

401891-53-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 401891-53-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,1,8,9 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 401891-53:
(8*4)+(7*0)+(6*1)+(5*8)+(4*9)+(3*1)+(2*5)+(1*3)=130
130 % 10 = 0
So 401891-53-0 is a valid CAS Registry Number.

401891-53-0Downstream Products

401891-53-0Relevant articles and documents

Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands

Peters, Jens-Uwe,Hoffmann, Torsten,Schnider, Patrick,Stadler, Heinz,Koblet, Andreas,Alker, André,Poli, Sonia Maria,Ballard, Theresa M.,Spooren, Will,Steward, Lucinda,Sleight, Andrew J.

scheme or table, p. 3405 - 3408 (2010/07/16)

During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with additional affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogues from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.

Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia

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Page/Page column 14, (2010/02/15)

The present invention relates to a method of treating schizophrenia which comprises administering a therapeutically effective amount of a compound of formula I wherein R1, R2, and R3 are as defined in the specification or to pharmaceutically active acid-addition salts thereof.

DUAL NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA

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Page 135, (2008/06/13)

The use of compounds of the general formula wherein the substituents are as described in claim 1 or pharmaceutically active acid-addition salts thereof for the preparation of medicaments for the treatment of schizophrenia.

Substituted 4-phenyl-pyridine compounds with activity as antagonists of neurokinin 1 receptors

-

, (2008/06/13)

Substituted 4-phenyl-pyridine compounds with activity as antagonists of Neurokinin 1 receptors, methods of making these compounds and preparing.

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