40348-66-1

Basic information

• Product Name: (R)-1,2-Butanediol
• Synonyms: (R)-(+)-1,2-BUTANEDIOL;(2R)-1,2-Butanediol;(R)-Butane-1,2-diol;(2R)-1,2-Dihydroxybutane;(2R)-Butane-1,2-diol;(R)-1,2-Butanediol;(R)-1,2-Butanediol,99%e.e.
• CAS NO: 40348-66-1
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.12
• Product Categories: API intermediates
• Mol File: 40348-66-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 60°C/1mmHg(lit.)
• Flash Point: 93.3 °C
• Appearance: /
• Density: 1.001g/cm³
• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.4360-1.4400
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (R)-1,2-Butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2-Butanediol(40348-66-1)
• EPA Substance Registry System: (R)-1,2-Butanediol(40348-66-1)

Safety Data

• Hazardous Substances Data: 40348-66-1(Hazardous Substances Data)

Usage

General Description

(R)-1,2-Butanediol, also known as R-butanediol, is a chiral compound that consists of two alcohol functional groups. It is a colorless, viscous liquid with a mildly sweet taste and is often used as a solvent in chemical reactions and as a humectant in the production of cosmetics and personal care products. It also has potential applications as a precursor in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, (R)-1,2-Butanediol has been studied for its potential use as a bio-based fuel or fuel additive, and ongoing research continues to explore its potential in various industrial and commercial applications.

InChI:InChI=1/C4H10O2/c1-2-4(6)3-5/h4-6H,2-3H2,1H3/t4-/m1/s1

Upstream product

• 28954-12-3 (2S,3S)-2-amino-3-hydroxybutanoic acid 
• 86106-09-4 (R)-(+)-3,4-dihydroxy-1-butene 
• 106-88-7 ethyloxirane 
• 100-52-7 benzaldehyde 
• 584-03-2 1,2-dihydroxybutane 

Downstream Products

• 2482-57-7 1-bromo-2-butanol 
• 30608-62-9 (S)-(-)-1,2-epoxybutane 
• 106-88-7 (R)-(+)-1,2-epoxybutane 
• 103745-07-9 (R)-2-hydroxybutyl p-toluenesulfonate 
• 167354-12-3 (2R)-1-(benzyloxy)-2-butanol 
• 123-72-8 butyraldehyde 

Relevant articles and documents

Kinetic Resolution of 1,2-Diols via NHC-Catalyzed Site-Selective Esterification

A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.

Synthesis of optically pure terminal epoxide and 1,2-diol via hydrolytic kinetic resolution catalyzed by new heterometallic salen complexes

The inactive chiral (salen)Co complex is easily activated by InCl 3 and TlCl3 Lewis acids by forming heterometallic salen complexes. These complexes show very high catalytic activity for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and 1,2-diols simultaneously via hydrolytic kinetic resolution. Strong synergistic effects of different Lewis acids, Co-In and Co-Tl, were exhibited in the catalytic process. The system described is very simple and efficient. Copyright Taylor & Francis Group, LLC.

Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al

The asymmetric hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new easily synthesized dimeric chiral (salen)Co bearing Al, provides a practical and straightforward method for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and diols. An inorganic acid, HCl is applied first time for the asymmetric ring opening reaction of terminal epoxides. Reactions are conveniently carried out at room temperature under an air atmosphere.