40560-86-9Relevant articles and documents
Ph3P/I2-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines
Phakhodee, Wong,Wangngae, Sirilak,Wiriya, Nittaya,Pattarawarapan, Mookda
supporting information, p. 5351 - 5354 (2016/11/11)
A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidines in good to excellent yields under mild conditions.