4076-02-2Relevant articles and documents
Ostapkevich et. al.
, (1973)
A kind of improved 2, 3 - dimercapto method for the synthesis of the sodium
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Paragraph 0032; 0035; 0038; 0039, (2018/11/03)
The invention belongs to the organic or drug synthesis field and relates to a synthetic method of improved sodium 2,3-dimercaptosulphonate. The adopted technical scheme is as follows: sulfhydrylation reaction is adopted, wherein the PH value of sodium (potassium) bisulfide solution is an important process parameter of the sulfhydrylation reaction. Commercial NaHS solids are dissolved with water, halogenated acids such as concentrated hydrochloric acid and the like are used for neutralizing until the PH value is 6.5-7, and then the NaHS solution is reacted with 2,3-dibromo-1-propanesulfonic acid sodium salt; and besides, high-selectivity environment and condition are provided for the sulfhydrylation reaction of sodium 2,3-dimercaptosulphonate, hydrogen sulfide gas which is highly toxic is not used, and the working condition is improved; and furthermore, hydrogen chloride methanol solution is used for deleading reaction, the hydrogen sulfide gas which is highly toxic and has influence on environment is avoided, and the working condition is improved.
An improved synthesis of 2,3-dithiopurine propyl sodium Hydrosulfuryl reaction method
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Paragraph 0034; 0036; 0092; 0095; 0097; 0102; 0104, (2018/07/10)
The invention discloses a novel method for sulfhydrylation reaction in a synthesis process of 2,3-sodium dimercaptosulphonate. Different from the existing sulfhydrylation reaction, the sulfhydrylation reaction is fulfilled by introducing high pressure hydrogen sulfide gas into absolute ethyl alcohol solution of sodium alcoholate to obtain sodium hydrosulfide and then adding 2,3-dibromo-1-propanesulfonic acid sodium salt, and carrying out sulfhydrylation reaction under the condition of continuously introducing high pressure hydrogen sulfide in short time and under the high yield. Therefore, the bottleneck technology of the sulfhydrylation reaction in the synthesis process of 2,3-sodium dimercaptosulphonate, which is very troubled, is successfully solved.