428871-73-2

Basic information

• Product Name: 4-Amino-2-fluoro-5-nitrobenzotrifluoride
• Synonyms: 4-Amino-2-fluoro-5-nitrobenzotrifluoride;5-Fluoro-2-nitro-4-(trifluoromethyl)aniline, 2-Amino-4-fluoro-5-(trifluoromethyl)nitrobenzene;5-Fluoro-2-nitro-4-trifluoromethyl-phenylamine
• CAS NO: 428871-73-2
• Molecular Formula: C₇H₄F₄N₂O₂
• Molecular Weight: 224
• Mol File: 428871-73-2.mol

Chemical Properties

• Boiling Point: 281.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.586±0.06 g/cm3(Predicted)
• PKA: -3.68±0.25(Predicted)
• CAS DataBase Reference: 4-Amino-2-fluoro-5-nitrobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-2-fluoro-5-nitrobenzotrifluoride(428871-73-2)
• EPA Substance Registry System: 4-Amino-2-fluoro-5-nitrobenzotrifluoride(428871-73-2)

Safety Data

• Hazardous Substances Data: 428871-73-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-Amino-2-fluoro-5-nitrobenzotrifluoride is utilized as a key intermediate in the development of pharmaceuticals. Its unique combination of functional groups allows for the creation of a wide range of medicinal compounds, enhancing the therapeutic potential of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, 4-Amino-2-fluoro-5-nitrobenzotrifluoride serves as an essential component in the synthesis of various agrochemicals. Its properties make it suitable for the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Manufacturing:
4-Amino-2-fluoro-5-nitrobenzotrifluoride is employed as a vital ingredient in the production of dyes and pigments. Its chemical structure contributes to the color and stability of these products, making it an important component in the colorants industry.
Used in Specialty Chemicals Production:
As an important intermediate, 4-Amino-2-fluoro-5-nitrobenzotrifluoride is widely used in the production of specialty chemicals. Its unique chemical properties make it a valuable asset in the development and manufacturing of a broad spectrum of specialty products within the chemical industry.
Used as a Reagent in Organic Synthesis:
4-Amino-2-fluoro-5-nitrobenzotrifluoride also functions as a reagent in organic synthesis. Its role in various chemical reactions facilitates the synthesis of complex organic compounds, further expanding its applications across different sectors of the chemical industry.

Upstream product

• 1026932-27-3 N-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide 
• 1026828-94-3 N-(5-fluoro-2-nitro-4-trifluoromethyl-phenyl)-acetamide 

Downstream Products

• 179062-06-7 1,2-diamino-4-fluoro-5-trifluoromethylbenzene 
• 473537-10-9 tert-butyl (5-fluoro-2-nitro-4-(trifluoromethyl)phenyl)carbamate 
• 167017-55-2 8-(4-Methyl-2-phenyl-1H-imidazol-1-yl)-7-trifluoromethyl[1,2,4]triazolo-[4,3-a]quinoxaline-1,4(2H,5H)-dione, hydrochloride 
• 579474-35-4 5-(cyclopropylmethoxy)-2-nitro-4-(trifluoromethyl)aniline 

Relevant articles and documents

BENZOIMIDAZOLES AS PROLYL HYDROXYLASE INHIBITORS

The present invention is directed to benzoimidazole compounds of the formula (1) and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and met

COMBINATION OF MGLUR2 ANTAGONIST AND ACHE INHIBITOR FOR TREATMENT OF ACUTE AND/OR CHRONIC NEUROLOGICAL DISORDERS

The present invention relates to a method of treatment or prevention of acute and/or chronic neurological disorders, to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic Glutamate receptor 2 antagonist (mGluR2 antagonist), to the use of an AChE inhibitor and a mGluR2 antagonist in the preparation of a medicament, and. to kits comprising an AChE inhibitor and a mGluR2 antagonist.

Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: Antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors

A series of mono-, di-, tri-, and tetrasubstituted 1,4- dihydroquinoxaline-2,3-diones (QXs) were synthesized and evaluated as antagonists at N-methyl-D-aspartate (NMDA)/glycine sites and α-amino-3- hydroxy-5-methylisoxazole-4-propionic acid-preferring non-NMDA receptors. Antagonist potencies were measured by electrical assays in Xenopus oocytes expressing rat whole brain poly(A)+ RNA. Trisubstituted QXs 17a (ACEA 1021), 17b (ACEA 1031), 24a, and 27, containing a nitro group in the 5 position and halogen in the 6 and 7 positions, displayed high potency (K(b) ~ 6-8 nM) at the glycine site, moderate potency at non-NMDA receptors (K(b) = 0.9-1.5 μM), and the highest (120-250-fold) selectivity in favor of glycine site antagonism over non-NMDA receptors. Tetrasubstituted QXs 17d,e were more than 100-fold weaker glycine site antagonists than the corresponding trisubstituted QXs with F being better tolerated than Cl as a substituent at the 8 position. Di- and monosubstituted QXs showed progressively weaker antagonism compared to trisubstituted analogues. For example, removal of the 5-nitro group of 17a results in a ~100-fold decrease in potency (10a,b,z), while removal of both halogens from 17a results in a ~3000-fold decrease in potency (10v). In terms of steady-state inhibition, most QX substitution patterns favor antagonism at NMDA/glycine sites over antagonism at non-NMDA receptors. Among the QXs tested, only 17i was slightly selective for non- NMDA receptors.