4356-66-5Relevant articles and documents
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: Discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones
Bertolasi, Valerio,Bortolini, Olga,Donvito, Adelaide,Fantin, Giancarlo,Fogagnolo, Marco,Giovannini, Pier Paolo,Massi, Alessandro,Pacifico, Salvatore
experimental part, p. 6579 - 6586 (2012/09/08)
Diaryl α-diketones do not undergo polarity reversal in the presence of (benzo)thiazolium carbenes but are engaged in a novel multicomponent reaction with water to efficiently give medicinally relevant 1,4-thiazin-3-one heterocycles. Three different sets of conditions have been optimized to furnish the title compounds in fair to excellent yields depending on the electronic properties of α-diketone aromatic substituents and thiazolium or benzothiazolium substrate. A plausible reaction mechanism is also proposed based on the isolation and characterization of the postulated key intermediate and isotopic labeling experiments.
1H NMR Study of cis-trans Isomerization in Two Analogs of the Thiol Form of Thiamine
Chriss, Derald,Miller, Robert H.,Echols, Richard E.,Vessel, Ellen
, p. 75 - 79 (2007/10/02)
Proton magnetic resonance (1H NMR) was used to study cis-trans isomerization in N-methyl-N-(1-methylthio-2-propenyl)formamide and N-benzyl-N-(1-methylthio-2-propenyl)formamide, two analogs of the thiol form of thiamine.Benzene dilution studies and shift r
