438450-39-6

Basic information

• Product Name: 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid
• Synonyms: 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid;2-(3-chloropyridin-2-yl)-5-(trifluoromethyl)pyrazole-3-carboxylic acid;1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid;2-(3-chloropyridin-2-yl)-5-(trifluoromethyl)pyrazole-3-carboxylic
• CAS NO: 438450-39-6
• Molecular Formula: C₁₀H₅ClF₃N₃O₂
• Molecular Weight: 291.6138096
• Mol File: 438450-39-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 178-179 °C
• Boiling Point: 419.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.66±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.35±0.36(Predicted)
• CAS DataBase Reference: 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid(438450-39-6)
• EPA Substance Registry System: 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid(438450-39-6)

Safety Data

• Hazardous Substances Data: 438450-39-6(Hazardous Substances Data)

Usage

General Description

1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid is a chemical compound with the molecular formula C10H6ClF3N2O2. It is a derivative of pyrazole and contains a trifluoromethyl group and a carboxylic acid functional group. 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid is often used in the pharmaceutical industry as a building block for the synthesis of various drugs and agrochemicals. It has been studied for its potential therapeutic applications, including as an anti-inflammatory and anticancer agent. Additionally, it has potential uses in the field of material science and as a reagent in chemical research.

Upstream product

• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 22841-92-5 3-chloro-2(1H)-pyridinone hydrazone 
• 124-38-9 carbon dioxide 
• 438450-38-5 3-chloro-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine 
• 22841-92-5 (3-chloro-2-pyridyl)hydrazine 
• 1352548-01-6 3-chloro-2-(5-(furan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridine 
• 15788-03-1 1,1,1-trifluoro-4-(furan-2-yl)-4-hydroxybut-3-en-2-one 
• 2402-77-9 2,3-dichloro-pyridine 

Downstream Products

• 1422677-87-9 2-(3-chloro-2-pyridyl)-N-[2-methyl-4-chloro-6-[(diethyl-λ⁴-sulfanylidene)carbamoyl]phenyl]-5-(trifluoromethyl)-2H-pyrazole-3-carboxamide 
• 1422677-86-8 2-(3-chloro-2-pyridyl)-N-[2,4-dichloro-6-[(bis-2-propyl-λ⁴-sulfanylidene)carbamoyl]phenyl]-5-(trifluoromethyl)-2H-pyrazole-3-carboxamide 

Relevant articles and documents

Synthesis and Insecticidal Evaluation of Novel Anthranilic Diamides Derivatives Containing 4-Chlorine Substituted N-Pyridylpyrazole

To search for potent insecticides targeting at ryanodine receptors (RyRs), a series of novel anthranilic diamides analogs containing 4-chlorine N-pyridylpyrazole were designed and synthesized. Their insecticidal activities were evaluated and the preliminary structure-activity relationships (SARs) were discussed. The insecticidal results showed that some of the compounds (8a—8h, 8m, 8n) exhibited good larvicidal activities against oriental armyworm at 2.5 mg·L–1, and compound 8m possessed 60% insecticidal activity at 0.5 mg·L–1. For diamondback moth, 8m exhibited better activity than Chlorantraniliprole at a hundred fold preference. The calcium imaging technique experiment results suggested that compound 8m could increase the intracellular [Ca2+]i. With the neurons preincubated experiment, the results confirmed that the target of this series of compounds could be RyRs in the central larvae neurons of oriental armyworm. The results indicated that compound 8m could respond as a potential modulator of the insect ryanodine receptor.

Method of controlling particular insect pests by applying anthranilamide compounds

This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a benzoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.

PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF

The present invention relates to a process for preparing N-substituted 1 H-pyrazole-5-carboxylic acid compounds of the formula l-A and derivatives thereof, in particular the corresponding carbonylchloride compounds (acid chlorides). It also relates to the use of these acid chlorides for preparing anthranilamide derivatives that are useful pesticides. in which the variables are as defined in the claims and the specification comprising the steps of i) reacting a compound of the formula (II) with a base selected from combinations of a magnesium-organic compound having a carbon bound magnesium and a secondary amine and magnesium amides of secondary amines in the presence of a lithium halide, where the base is used in an amount sufficient to achieve at least 80 % deprotonation of the compound of formula (II); and subjecting the product obtained in step (i) to a carboxylation by reacting it with carbon dioxide or a carbon dioxide equivalent, to obtain a magnesium salt of the compound of formula (l-A) and optionally aqueous workup to obtain the compound of the formula (l-A) as a free acid.