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CAS

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440105-60-2

5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 440105-60-2 Structure

  • Basic information

    1. Product Name: 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole
    2. Synonyms: 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole
    3. CAS NO:440105-60-2
    4. Molecular Formula:
    5. Molecular Weight: 359.519
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 440105-60-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole(440105-60-2)
    11. EPA Substance Registry System: 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole(440105-60-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 440105-60-2(Hazardous Substances Data)

440105-60-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 440105-60-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,0,1,0 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 440105-60:
(8*4)+(7*4)+(6*0)+(5*1)+(4*0)+(3*5)+(2*6)+(1*0)=92
92 % 10 = 2
So 440105-60-2 is a valid CAS Registry Number.

440105-60-2Relevant articles and documents

Inhibitors of prenyl-protein transferase

-

, (2008/06/13)

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

3-Aminopyrrolidinone farnesyltransferase inhibitors: Design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

Bell, Ian M.,Gallicchio, Steven N.,Abrams, Marc,Beese, Lorena S.,Beshore, Douglas C.,Bhimnathwala, Hema,Bogusky, Michael J.,Buser, Carolyn A.,Culberson, J. Christopher,Davide, Joseph,Ellis-Hutchings, Michelle,Fernandes, Christine,Gibbs, Jackson B.,Graham, Samuel L.,Hamilton, Kelly A.,Hartman, George D.,Heimbrook, David C.,Homnick, Carl F.,Huber, Hans E.,Huff, Joel R.,Kassahun, Kelem,Koblan, Kenneth S.,Kohl, Nancy E.,Lobell, Robert B.,Lynch Jr., Joseph J.,Robinson, Ronald,Rodrigues, A. David,Taylor, Jeffrey S.,Walsh, Eileen S.,Williams, Theresa M.,Zartmant, C. Blair

, p. 2388 - 2409 (2007/10/03)

A series of macrocyclic 3-aminopyrrolidinone farnesyltransferase inhibitors (FTIs) has been synthesized. Compared with previously described linear 3-aminopyrrolidinone FTIs such as compound 1, macrocycles such as 49 combined improved pharmacokinetic prope

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