5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Base Information

Chemical Name:5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole
CAS No.:440105-60-2
Molecular Formula:C₁₉H₂₆FN₃OSi
Molecular Weight:359.519
Hs Code.:

Synonyms:5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Suppliers and Price of 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

There total 5 articles about 5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 127056-57-9
4-(tert-butyldimethylsilyloxymethyl)-1-(triphenylmethyl)imidazole

: 440105-59-9
2-fluoro-4-(1-hydroxyethyl)benzonitrile

: 440105-60-2
5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Guidance literature:: 4-(tert-butyldimethylsilyloxymethyl)-1-(triphenylmethyl)imidazole; 2-fluoro-4-(1-hydroxyethyl)benzonitrile; With trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 - 0 ℃; for 18h;

In methanol; for 3h; Further stages.; Heating;
DOI:10.1021/jm010531d

Reference yield:

: 127056-57-9
4-(tert-butyldimethylsilyloxymethyl)-1-(triphenylmethyl)imidazole

: 440105-60-2
5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Guidance literature:: With trifluoromethanesulfonic acid anhydride; In methanol; dichloromethane;

Reference yield:

: 85070-67-3
2-fluoro-4-methylbenzonitrile

: 440105-60-2
5-[[(tert-butyldimethylsilyl)oxy]methyl]-1-[1-(4-cyano-3-fluorophenyl)ethyl]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 65 percent / NBS; AIBN / CCl₄ / 24 h / Heating

2.1: 77 percent / aq. AgNO₃ / ethanol / 3 h / Heating

3.1: 74 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

4.1: Tf₂O; DIEA / CH₂Cl₂ / 18 h / -78 - 0 °C

4.2: 92 percent / methanol / 3 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); trifluoromethylsulfonic anhydride; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; dichloromethane;
DOI:10.1021/jm010531d