444344-90-5 Usage
Uses
Used in Pharmaceutical Synthesis:
Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate is used as a precursor in the pharmaceutical industry for the synthesis of various organic molecules. Its unique structure and chemical properties make it a key component in the development of new drugs and pharmaceutical compounds.
Used in Drug Development:
In the field of drug development, Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate is employed as a building block for the creation of new organic molecules with potential pharmacological activities. Its role in drug development is crucial, as it can contribute to the discovery of novel therapeutic agents and improve existing ones.
Used in Organic Chemistry Research:
Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate is also used in organic chemistry research to study its chemical properties and potential applications. Researchers explore its reactivity, stability, and interactions with other molecules to better understand its role in organic synthesis and to develop new methods for its utilization.
Used in Chemical Intermediates Production:
As a versatile organic compound, Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate is used in the production of various chemical intermediates. These intermediates can be further processed or modified to create a wide range of chemical products, including specialty chemicals, agrochemicals, and other industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 444344-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,4,3,4 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 444344-90:
(8*4)+(7*4)+(6*4)+(5*3)+(4*4)+(3*4)+(2*9)+(1*0)=145
145 % 10 = 5
So 444344-90-5 is a valid CAS Registry Number.
444344-90-5Relevant academic research and scientific papers
BICYCLOESTER DERIVATIVE
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Page/Page column 12, (2010/11/24)
SUMMARY Novel bicycloester derivatives and pharmaceutically acceptable salts thereof have high DPP-IV inhibitory activity. SOLVING MEANS The novel bicycloester derivatives are represented by the general formula (1): Pharmaceutically acceptable salts there
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
Reynolds, Robert C,Johnson, Cheryl A,Piper, James R,Sirotnak, Frances M
, p. 237 - 242 (2007/10/03)
N-[4-[[2,4-diamino-6-pteridinyl)methyl]amino]bicyclo[2.2.2]octane-1- carbonyl]-L-glutamic acid (1) was synthesized and tested for antifolate activity. N-(4-Aminobicyclo[2.2.2]octane-1-carbonyl-L-glutamic acid dimethyl ester (6), the side chain precursor to subject compound 1, was synthesized readily via reported bicyclo[2.2.2]octane-1,4-dicarboxylic acid monoethyl ester (2). The side chain precursor 6 was alkylated by 6-(bromomethyl)-2,4-pteridinediamine (7). Subsequent ester hydrolysis then afforded 1. Antifolate and antitumor evaluation of 1 verses L1210 dihydrofolate reductase (DHFR) and three tumor cell lines (L1210, S180, and HL60) showed it to be ineffective. Although compound 1 was very similar to aminopterin structurally, the bicyclo[2.2.2]octane ring system in place of the phenyl ring in the p-aminobenzoate moiety effectively negates the stoichiometric binding displayed by many classical DHFR inhibitors bearing appropriate aromatic ring systems in the side chain.
