4465-44-5

Basic information

• Product Name: N-Trityl-L-serine methyl ester
• Synonyms: (S)-methyl 3-hydroxy-2-(tritylamino)propanoate;N-(TriphenylMethyl)-L-serine Methyl Ester;N-Trityl-L-serine Methyl Ester Trt-Ser-OMe;(4S)-4-aMinooxolan-3-one;(diphenylMethyl)benzene;Trt-Ser-OMe;N-Trityl-L-serine methyl ester 99%;Trt-L-Ser-Ome
• CAS NO: 4465-44-5
• Molecular Formula: C₂₃H₂₃NO₃
• Molecular Weight: 361.43
• Product Categories: pharmacetical;Amino Acid Derivatives;Peptide Synthesis;Serine
• Mol File: 4465-44-5.mol

Chemical Properties

• Melting Point: 148-150 °C(lit.)
• Boiling Point: 538.2 °C at 760 mmHg
• Flash Point: 279.3 °C
• Appearance: /
• Density: 1.169 g/cm³
• Vapor Pressure: 2.04E-12mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 14.01±0.10(Predicted)
• CAS DataBase Reference: N-Trityl-L-serine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-Trityl-L-serine methyl ester(4465-44-5)
• EPA Substance Registry System: N-Trityl-L-serine methyl ester(4465-44-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 4465-44-5(Hazardous Substances Data)

Usage

Uses

Used in Peptide Synthesis:
N-Trityl-L-serine methyl ester is utilized as a building block in peptide synthesis for its ability to protect the serine amino acid from unwanted side reactions. The trityl group ensures that the serine moiety remains intact and unreactive until the desired point in the synthesis process, at which the protective group can be selectively removed.
Used in Organic Chemistry:
In the realm of organic chemistry, N-Trityl-L-serine methyl ester serves as an important intermediate. Its methyl ester group facilitates easy modification and functionalization of the molecule, making it a valuable component in the creation of a variety of organic compounds with specific properties and applications.
Used in the Production of Biologically Active Molecules:
N-Trityl-L-serine methyl ester is also employed in the synthesis of biologically active molecules. Its protected serine structure allows for the incorporation of this amino acid into complex molecular frameworks without the risk of unwanted side reactions, which is crucial for the development of pharmaceuticals and other bioactive substances.

InChI:InChI=1/C23H23NO3/c1-27-22(26)21(17-25)24-23(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16,21,24-25H,17H2,1H3/t21-/m0/s1

Upstream product

• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 76-83-5 trityl chloride 
• 2788-84-3 (S)-serine methyl ester 
• 141-78-6 ethyl acetate 

Downstream Products

• 257887-94-8 1-O-(5'-carbomethoxypentyl)-2-tetrahydropyranyl-sn-glyceryl 2,2,2-trichloro-tert-butyl 2-carbomethoxy-2-(N-triphenylmethylamino)ethyl phosphite 
• 76357-12-5 (S)-methyl3-((methylsulfonyl)oxy)-2-(tritylamino)propanoate 
• 600157-66-2 methyl 3-(2-nitro-1H-imidazol-1-yl)-N-trityl-L-alaninate 
• 194861-65-9 methyl O-benzyl-N-trityl-L-serinate 
• 1221399-79-6 3-(3,5-difluoro-phenoxy)-2-(tritylamino)-propionic acid methyl ester 
• 1207188-09-7 (S)-methyl 3-(2-(benzylsulfanyl)pyrimidin-4-yloxy)-2-(tritylamino)propanoate 
• 1207188-10-0 (S)-methyl 3-(2-(benzylsulfanyl)-6-methylpyrimidin-4-yloxy)-2-(tritylamino)propanoate 
• 1207188-11-1 (S)-methyl 3-(2-(benzylsulfanyl)-6-phenylpyrimidin-4-yloxy)-2-(tritylamino)propanoate 
• 441348-02-3 (S)-3-[3'-(3-Propyl-ureido)-biphenyl-4-yloxy]-2-(trityl-amino)-propionic acid methyl ester 
• 441348-00-1 methyl O-(3'-amino-1,1'-biphenyl-4-yl)-N-triphenylmethyl-L-serinate 
• 647028-62-4 (2S,3R)-2-[5-[6-(N-tert-butyldimethylsilylcarbamoyloxy)-3-tert-butyldimethylsilyloxy-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-66-8 (2S,3R)-2-[5-[3,6-bis-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-92-0 (2S,3R)-2-[5-[3-acetoxy-6-tert-butyldimethylsilyloxy-1-methyl-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 
• 647028-65-7 (2S,3R)-2-[5-[3-acetoxy-6-(tert-butyldimethylsilyloxy)-4-hexynyl]oxazol-2-yl]-3-iodomethyl-1-tritylaziridine 

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