454-16-0

Basic information

• Product Name: 2-Fluoro-5-nitroanisole
• Synonyms: 2-Fluoro-5-nitroanisole;3-Methoxy-4-fluoronitrobenzene;4-Fluoro-3-methoxynitrobenzene;4-Fluoro-3-methoxynitrobenzene 2-Fluoro-5-nitroanisole;1-Fluoro-2-methoxy-4-nitrobenzene;Anisole, 2-fluoro-5-nitro- (8CI);4-Fluoro-3-methoxynitrobenzene, 1-Fluoro-2-methoxy-4-nitrobenzene, 2-Fluoro-5-nitrophenyl methyl ether;2-Fluoro-5-nitroanisole[4-Fluoro-3-Methoxynitrobenzene]
• CAS NO: 454-16-0
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.13
• EINECS: 1592732-453-0
• Product Categories: Multisubstituted Benzene;Aromatic Halides (substituted)
• Mol File: 454-16-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 69-71 °C
• Boiling Point: 270.3 °C at 760 mmHg
• Flash Point: 117.3 °C
• Appearance: /
• Density: 1.321 g/cm³
• Vapor Pressure: 0.0114mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Room temperature.
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-Fluoro-5-nitroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-5-nitroanisole(454-16-0)
• EPA Substance Registry System: 2-Fluoro-5-nitroanisole(454-16-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 454-16-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-5-nitroanisole is a chemical compound with the molecular formula C7H6FNO3. It is a nitro compound with a fluorine atom attached to the second carbon of the aromatic ring and a nitro group attached to the fifth carbon. This chemical is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has potential applications in the field of medicine and can be used as a building block in the production of various drugs and bioactive molecules. Additionally, it has been reported to have antimicrobial and antifungal properties, making it a promising candidate for the development of new drugs and treatments.

InChI:InChI=1/C7H6FNO3/c1-12-7-4-5(9(10)11)2-3-6(7)8/h2-4H,1H3

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 22510-08-3 2-fluoro-5-nitrophenol 
• 74-88-4 methyl iodide 
• 97-52-9 2-methoxy-4-nitrophenylamine 

Downstream Products

• 958245-17-5 1-(2-methoxy-4-nitrophenyl)-4-methyl-1H-imidazole 
• 1255701-91-7 1-(2-methoxy-4-nitro-phenyl)-5-methyl-1H-imidazole 
• 1351861-98-7 4-(3-iodophenoxy)-3-methoxyaniline 
• 1351861-99-8 4-(3-chloro-5-iodophenoxy)-3-methoxyaniline 
• 1351862-00-4 4-(3-fluoro-5-iodophenoxy)-3-methoxyaniline 
• 1351862-08-2 C₁₆H₁₃ClN₂O₂ 
• 1351862-01-5 5-chloro-2-(3-iodophenoxy)-1-methoxybenzene 
• 1351862-02-6 4-chloro-1-(3-chloro-5-iodophenoxy)-2-methoxybenzene 
• 1351862-03-7 4-chloro-1-(3-fluoro-5-iodophenoxy)-2-methoxybenzene 
• 1430229-98-3 C₂₁H₁₅BrClN₃O₄ 

Relevant articles and documents

BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS

The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain inhibitors; (I), in which R1, R2, R3, R4, L1, L2, Cy1, Cy2, X, n, and dotted line have the same meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders associated as bromodomain inhibitors. The present disclosure also provides preparation of compounds and pharmaceutical formulations comprising at least one of bicyclic heterocyclic derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent, or excipient.

NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS

Certain 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents.

Facile preparation of aromatic fluorides by deaminative fluorination of aminoarenes using hydrogen fluoride combined with bases

One-pot deaminative fluorination of aminoarenes including heteroaromatics, namely, diazotization of aminoarenes followed by in situ fluoro-dediazoniation of the corresponding diazonium ions, was successfully accomplished to produce fluoroarenes in high yields by using hydrogen fluoride combined with base solutions. The diazotization stage has been found to play the most important part in yielding fluoroarenes effectively. It was greatly influenced by the composition of the HF solution and enhanced by employing appropriate amounts of bases such as pyridine under carefully controlled conditions. The fluoro-dediazoniation stage was effectively accelerated photochemically to afford fluoroarenes having polar substituents such as hydroxyl, nitro and so on in high yields.