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456-07-5

456-07-5

Identification

  • Product Name:Benzamide,4-fluoro-N-hydroxy-

  • CAS Number: 456-07-5

  • EINECS:

  • Molecular Weight:155.129

  • Molecular Formula: C7H6 F N O2

  • HS Code:

  • Mol File:456-07-5.mol

Synonyms:Benzohydroxamicacid, p-fluoro- (6CI,7CI,8CI); 4-Fluoro-N-hydroxybenzamide;4-Fluorobenzohydroxamic acid; 4-Fluorobenzoylhydroxamic acid; NSC 111683;p-Fluorobenzohydroxamic acid

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Price
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  • Purchase
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:4-FLUORO-N-HYDROXYBENZAMIDE 95.00%
  • Packaging:5G
  • Price:$ 1010.63
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 23 Articles be found

Cu(II)-Catalyzed C-H Amidation/Cyclization of Azomethine Imines with Dioxazolones via Acyl Nitrenes: A Direct Access to Diverse 1,2,4-Triazole Derivatives

Liu, Xiang,Li, Wen,Jiang, Wenxuan,Lu, Hao,Liu, Jiali,Lin, Yijun,Cao, Hua

supporting information, p. 613 - 618 (2022/01/20)

We report a Cu(II)-catalyzed C-H amidation/cyclization of azomethine imines with dioxazolones as acyl nitrene transfer reagents under additive-and ligand-free conditions. An array of 1,2,4-triazolo[1,5-a]pyridine derivatives were afforded in moderate to good yields with excellent functional group tolerance. In addition, scale-up reaction and photoluminescence properties were discussed.

Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones

Yu, Yongqi,Xia, Zhen,Wu, Qianlong,Liu, Da,Yu, Lin,Xiao, Yuanjiu,Tan, Ze,Deng, Wei,Zhu, Gangguo

supporting information, p. 1263 - 1266 (2020/10/08)

A highly novel and direct synthesis of benzoxazinones was developed via Cp*Co(III)-catalyzed C–H activation and [3 + 3] annulation between sulfoxonium ylides and dioxazolones. The reaction is conducted under base-free conditions and tolerates various functional groups. Starting from diverse readily available sulfoxonium ylides and dioxazolones, a variety of benzoxazinones could be synthesized in one step in 32%-75% yields.

Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones

Zuo, Youpeng,He, Xinwei,Tang, Qiang,Hu, Wangcheng,Zhou, Tongtong,Hu, Wenbo,Shang, Yongjia

supporting information, p. 2117 - 2123 (2020/12/22)

An cascade intramolecular 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, phenyl hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones using unexpensive Pd(PPh3)4 as catalyst has been developed. The protocol enables the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields. (Figure presented.).

Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides

Zhang, Xinyu,Lin, Bo,Chen, Jianhui,Chen, Jiajia,Luo, Yanshu,Xia, Yuanzhi

supporting information, p. 819 - 825 (2021/02/01)

The N-acyloxyamides were employed as effective N-acyl nitrene precursors in reactions with thioethers under the catalysis of a commercially available Ru(II) complex, from which a variety of sulfimides were synthesized efficiently and mildly. If an allyl group is contained in the thioether precursor, the [2,3]-sigmatropic rearrangement of the sulfimide occurs simultaneously and the N-allyl-N-(thio)amides were obtained as the final products. Preliminary mechanistic studies indicated that the Ru-nitrenoid species should be a key intermediate in the transformation.

Thioether-Directed NiH-Catalyzed Remote γ-C(sp3)-H Hydroamidation of Alkenes by 1,4,2-Dioxazol-5-ones

Chen, Qishu,Du, Bingnan,Ouyang, Yuxin,Yu, Wing-Yiu

supporting information, p. 14962 - 14968 (2021/09/29)

A NiH-catalyzed thioether-directed cyclometalation strategy is developed to enable remote methylene C-H bond amidation of unactivated alkenes. Due to the preference for five-membered nickelacycle formation, the chain-walking isomerization initiated by the NiH insertion to an alkene can be terminated at the γ-methylene site remote from the alkene moiety. By employing 2,9-dibutyl-1,10-phenanthroline as the ligand and dioxazolones as the reagent, the amidation occurs at the γ-C(sp3)-H bonds to afford the amide products in up to 90% yield (>40 examples) with remarkable regioselectivity (up to 24:1 rr).

Process route upstream and downstream products

Process route

4-fluorobenzoyl chloride
403-43-0

4-fluorobenzoyl chloride

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;
93%
With hydroxylamine hydrochloride; triethylamine; In chloroform; at 20 ℃; for 1h;
34%
With hydroxylamine hydrochloride; at 0 ℃;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h; Inert atmosphere;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 25 ℃;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 14h;
With hydroxylamine hydrochloride; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 2h;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 6h;
With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
4-Fluorobenzoic acid; With 4-[(2,4-(MeO)2-benzyl)-ONHCH2]-3-MeO-phenoxy-Merrified resin; dacarbazine; dmap; In N,N-dimethyl-formamide; at 20 ℃;
With trifluoroacetic acid; In dichloromethane;
83%
4-Fluorobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
With hydroxylamine hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;
59%
With Carbonyldiimidazole; hydroxylamine; In water; acetonitrile; Inert atmosphere;
Multi-step reaction with 2 steps
1: acetonitrile / 1 h / 20 °C
2: hydroxylamine / acetonitrile; water / 14 h / 23 °C
With hydroxylamine; In water; acetonitrile;
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide / water; tetrahydrofuran / 1 h / pH 4.5
2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 1 h
With palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; water;
4-Fluorobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
With hydroxylamine hydrochloride; at 0 - 20 ℃; Inert atmosphere;
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 60 °C
2: potassium carbonate; hydroxylamine hydrochloride / water; ethyl acetate / 0 - 25 °C
With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; water; ethyl acetate;
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
2: hydroxylamine hydrochloride; sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C / Inert atmosphere
With oxalyl dichloride; hydroxylamine hydrochloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water;
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 60 °C
2: hydroxylamine hydrochloride; potassium carbonate / ethyl acetate; water / 2 h / 0 - 20 °C
With thionyl chloride; hydroxylamine hydrochloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
4-Fluorobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 1h; Glovebox;
With hydroxylamine hydrochloride; In tetrahydrofuran; at 20 ℃; Glovebox;
4-fluorobenzylic alcohol
459-56-3

4-fluorobenzylic alcohol

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
4-fluorobenzylic alcohol; With 1-hydroxy-pyrrolidine-2,5-dione; [bis(acetoxy)iodo]benzene; In acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere; Green chemistry;
With hydroxylamine; In water; acetonitrile; for 12h; Inert atmosphere; Green chemistry;
92%
1-(p-fluorophenylcarbonyl)imidazole
90172-63-7

1-(p-fluorophenylcarbonyl)imidazole

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
With hydroxylamine; In water; acetonitrile; at 23 ℃; for 14h;
4-fluorobenzoic acid ethyl ester
451-46-7

4-fluorobenzoic acid ethyl ester

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
With hydrogenchloride; hydroxylamine;
4-fluoro-N-hydroxy-benzamide
456-07-5

4-fluoro-N-hydroxy-benzamide

Conditions
Conditions Yield
Methylester d. entspr. Saeure, Hydroxylamin, alkal. Medium (NaOH);
Ethylester d. entspr. Saeure, Hydroxylamin, alkal. Medium (NaOH);
4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

Conditions
Conditions Yield
p-Fluorbenzoylchlorid, NH2OH;
4-Fluor-benzoesaeure-ethylester, NH2OH, NaOCH3, Me.;
4-fluoro-N-hydroxy-benzamide
456-07-5

4-fluoro-N-hydroxy-benzamide

4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

Conditions
Conditions Yield
With wool supported manganese dioxide nanoparticles; at 20 ℃; for 9h;
87 %Chromat.
4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

para-fluorophenyl isocyanate
1195-45-5

para-fluorophenyl isocyanate

Conditions
Conditions Yield
4-fluorobenzohydroxamic acid; With Carbonyldiimidazole; In acetonitrile; at 20 ℃; for 0.666667h; Inert atmosphere;
In acetonitrile; at 60 ℃; Inert atmosphere;
With N-ethyl-N,N-diisopropylamine; 4-Nitrobenzenesulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;
2-chloromethylpyridine
4377-33-7

2-chloromethylpyridine

4-fluorobenzohydroxamic acid
456-07-5

4-fluorobenzohydroxamic acid

4-fluoro-N-(pyridin-2-ylmethoxy)benzamide

4-fluoro-N-(pyridin-2-ylmethoxy)benzamide

Conditions
Conditions Yield
4-fluorobenzohydroxamic acid; With potassium hydroxide; In methanol; for 0.5h; Reflux;
2-chloromethylpyridine; With sodium carbonate; In methanol; water; at 0 - 100 ℃; for 5h;

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  • Emails:market@keyingchem.com
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