Welcome to LookChem.com Sign In|Join Free

CAS

  • or
TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

460094-85-3 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 460094-85-3 Structure
  • Basic information

    1. Product Name: TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE
    2. Synonyms: TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE
    3. CAS NO:460094-85-3
    4. Molecular Formula: C16H23BrN2O2
    5. Molecular Weight: 355.28
    6. EINECS: N/A
    7. Product Categories: alkyl bromide
    8. Mol File: 460094-85-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE(460094-85-3)
    11. EPA Substance Registry System: TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE(460094-85-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 460094-85-3(Hazardous Substances Data)

460094-85-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 460094-85-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,0,0,9 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 460094-85:
(8*4)+(7*6)+(6*0)+(5*0)+(4*9)+(3*4)+(2*8)+(1*5)=143
143 % 10 = 3
So 460094-85-3 is a valid CAS Registry Number.

460094-85-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-[(2-bromophenyl)methyl]piperazine-1-carboxylate

1.2 Other means of identification

Product number -
Other names TERT-BUTYL 4-(2-BROMOBENZYL)PIPERAZINE-1-CARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:460094-85-3 SDS

460094-85-3Relevant articles and documents

De novo design, synthesis and evaluation of benzylpiperazine derivatives as highly selective binders of Mcl-1

Ding, Xiao,Li, Yan,Lv, Li,Zhou, Mi,Han, Li,Zhang, Zhengxi,Ba, Qian,Li, Jingquan,Wang, Hui,Liu, Hong,Wang, Renxiao

, p. 1986 - 2014 (2014/01/06)

Considerable efforts have been made to the development of small-molecule inhibitors of antiapoptotic B-cell lymphoma 2 (Bcl-2) family proteins (such as Bcl-2, Bcl-xL, and Mcl-1) as a new class of anticancer therapies. Unlike general inhibitors

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2

Ho, Ginny D.,Bercovici, Ana,Tulshian, Deen,Greenlee, William J.,Fawzi, Ahmad,Fernandez, Xiomara,McLeod, Robbie L.,Smith Torhan, April,Zhang, Hongtao

, p. 3028 - 3033 (2008/02/02)

A series of 4-[2-(aminomethyl)phenyl]-1-[bis(2-chlorophenyl)methyl]-4-hydroxypiperidine analogs has been identified as nociceptin receptor ligands. These compounds display high affinity and functional activity at the nociceptin receptor. The synthesis and

N-sulfonylcarboximidamide apoptosis promoters

-

Page/Page column 21, (2008/06/13)

Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors

Bolognesi, Maria Laura,Cavalli, Andrea,Andrisano, Vincenza,Bartolini, Manuela,Banzi, Rita,Antonello, Alessandra,Rosini, Michela,Melchiorre, Carlo

, p. 917 - 928 (2007/10/03)

Ambenonium (1), an old AChE inhibitor, is endowed with an outstanding affinity and a peculiar mechanism of action that, taken together, make it a very promising pharmacological tool for the treatment of Alzheimer's disease (AD). Unfortunately, the bisquaternary structure of 1 prevents its passage through the blood brain barrier. In a search of centrally active ambenonium derivatives, we planned to synthesize tertiary amines of 1, such as 2 and 3. In addition, to add new insights into the binding mechanism of the inhibitor, we designed constrained analogues of ambenonium by incorporating the diamine functions into cyclic moieties (4-12). The biological evaluation of the new compounds has been assessed in vitro against human AChE and BChE. All tertiary amine derivatives resulted more than 1000-fold less potent than 1 and, unlike prototype, did not show any selectivity between the two enzymes. This result, because of recent findings concerning the role of BChE in AD, makes our compounds, endowed with a well-balanced profile of AChE/BChE inhibition, valuable candidates for further development. To better clarify the interactions that account for the high affinity of 1, docking simulations and molecular dynamics studies on the AChE-1 complex were also carried out.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 460094-85-3