473416-81-8

Basic information

• Product Name: 4-Fluoro-1H-indazole-5-carbonitrile
• Synonyms: 4-Fluoro-1H-indazole-5-carbonitrile;1H-Indazole-5-carbonitrile,4-fluoro-(9CI);5-Cyano-4-fluoro (1H)indazole ;1H-Indazole-5-carbonitrile, 4-fluoro-
• CAS NO: 473416-81-8
• Molecular Formula: C8H4FN3
• Molecular Weight: 161.1358632
• Product Categories: HALIDE
• Mol File: 473416-81-8.mol

Chemical Properties

• Boiling Point: 367.476 °C at 760 mmHg
• Flash Point: 176.043 °C
• Appearance: /
• Density: 1.44
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.65
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Fluoro-1H-indazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-1H-indazole-5-carbonitrile(473416-81-8)
• EPA Substance Registry System: 4-Fluoro-1H-indazole-5-carbonitrile(473416-81-8)

Safety Data

• Hazardous Substances Data: 473416-81-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Fluoro-1H-indazole-5-carbonitrile is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure, including the fluoro and carbonitrile groups, makes it a valuable building block in the development of new drugs, potentially leading to improved therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-Fluoro-1H-indazole-5-carbonitrile serves as a key component in the design and synthesis of novel bioactive molecules. Its presence in these molecules can influence their binding affinity, selectivity, and overall pharmacological properties, making it an essential tool for researchers in drug discovery and development.
Used in Chemical Synthesis:
4-Fluoro-1H-indazole-5-carbonitrile is utilized as a reagent in various chemical synthesis processes. Its versatility in forming different types of chemical bonds allows it to be employed in the preparation of a wide array of compounds, from simple organic molecules to complex bioactive substances.

InChI:InChI=1/C8H4FN3/c9-8-5(3-10)1-2-7-6(8)4-11-12-7/h1-2,4H,(H,11,12)

Upstream product

• 149489-14-5 2,4-difluoro-3-formylbenzonitrile 

Downstream Products

• 1041481-59-7 4-fluoro-1H-indazole-5-carboxylic acid 

Relevant articles and documents

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).

NOVEL 1H-INDAZOLE COMPOUND

The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by -CO-NH- or -NH-CO-, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.