149489-14-5

Basic information

• Product Name: 2,4-DIFLUORO-3-FORMYLBENZONITRILE
• Synonyms: 2,4-DIFLUORO-3-FORMYLBENZONITRILE
• CAS NO: 149489-14-5
• Molecular Formula: C₈H₃F₂NO
• Molecular Weight: 167.12
• EINECS: 604-604-1
• Mol File: 149489-14-5.mol

Chemical Properties

• Boiling Point: 207.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2,4-DIFLUORO-3-FORMYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUORO-3-FORMYLBENZONITRILE(149489-14-5)
• EPA Substance Registry System: 2,4-DIFLUORO-3-FORMYLBENZONITRILE(149489-14-5)

Safety Data

• Hazardous Substances Data: 149489-14-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUORO-3-FORMYLBENZONITRILE is used as a synthetic intermediate for the development of new pharmaceutical compounds. Its unique structure allows for the introduction of the formyl group and fluorine atoms into organic molecules, which can enhance the pharmacological properties of the resulting drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIFLUORO-3-FORMYLBENZONITRILE is utilized as a key component in the synthesis of novel agrochemicals. The incorporation of the formyl and fluorine functionalities can lead to the creation of more effective and targeted pesticides or other agricultural chemicals.
Used in Organic Synthesis:
2,4-DIFLUORO-3-FORMYLBENZONITRILE is employed as a reactive building block in organic synthesis for the preparation of various organic molecules. Its reactivity and the presence of the formyl and nitrile groups make it a valuable precursor for the synthesis of complex organic compounds with potential applications in different fields.

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 3939-09-1 2,4-difluorobenzonitrile 

Downstream Products

• 473416-81-8 4-fluoro-1H-indazole-5-carbonitrile 
• 1026417-48-0 C₁₃H₁₁F₂NO₄ 
• 149489-15-6 3-[3-(Acetylamino-methyl)-2,6-difluoro-phenyl]-propionic acid 
• 1027036-50-5 3-(3-Cyano-2,6-difluoro-phenyl)-propionyl azide 
• 1026484-20-7 3-(3-Aminomethyl-2,6-difluoro-phenyl)-propionic acid 
• 1026459-42-6 2,4-Difluoro-3-(2-isocyanato-ethyl)-benzonitrile 
• 1026014-01-6 (E)-3-(3-Cyano-2,6-difluoro-phenyl)-acrylic acid benzyl ester 

Relevant articles and documents

2,3-DIHYDROBENZO[b]THIOPHENE DERIVATIVES AS HYPOXIA INDUCIBLE FACTOR-2(ALPHA) INHIBITORS

The present disclosure provides certain 2,3-dihydrobenzo[b]thiophene compounds that are Hypoxia Inducible Factor 2α (HIF-2α) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of HIF-2α. Also provided are pharmaceuti

PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates -(CO)h-(NRa)j-(CRb=CRc)k-Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X-Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).

NOVEL 1H-INDAZOLE COMPOUND

The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by -CO-NH- or -NH-CO-, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs

Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of nonnucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea hydrochloride (trovirdine; LY300046.HCl) as a highly potent anti-HIV-1 agent. Trovirdine is currently in phase one clinical trials for potential use in the treatment of AIDS. Extension of these structure-activity relationship studies to identify additional compounds in this series with improved properties is ongoing. A part of this work is described here. Replacement of the two aromatic moleties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated. In addition, the effects of multiple substitution in the phenyl ring were also studied. The antiviral activities were determined on wild-type and constructed mutants of HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell culture assays. Some selected compounds were determined on double- mutant viruses, HIV-1 (Ile100/Asn103) and HIV-1 (Ile100/Cys181). A number of highly potent analogs were synthesized. These compounds displayed IC50's against wild-type RT between 0.6 and 5 nM. In cell culture, these agents inhibited wild-type HIV-1 with ED50's between I and 5 nM in MT-4 cells. In addition, these derivatives inhibited mutant HIV-1 RT (Ile 100) with IC50's between 20 and 50 nM and mutant HIV-1 RT (Cys 181) with IC50's between 4 and 10 nM, and in cell culture they inhibited mutant HIV-1 (Ile100) with ED50's between 9 and 100 nM and mutant HIV-1 (Cys181) with ED50's between 3 and 20 nM.