47375-34-8

Basic information

• Product Name: Boc-O-tert-butyl-L-tyrosine
• Synonyms: BOC-L-TYR(TBU)-OH;BOC-O-T-BUTYL-L-TYROSINE;BOC-O-TERT-BUTYL-L-TYROSINE;BOC-TYR(TBU)-OH;BOC-TYROSINE(TBU)-OH;BOC-TYR(BUT)-OH;TIMTEC-BB SBB006926;N-ALPHA-T-BOC-O-T-BUTYL-L-TYROSINE
• CAS NO: 47375-34-8
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.41
• Product Categories: Amino Acids;Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 47375-34-8.mol

Chemical Properties

• Melting Point: 113-118 °C
• Boiling Point: 484 °C at 760 mmHg
• Flash Point: 246.5 °C
• Appearance: /
• Density: 1.116 g/cm³
• Vapor Pressure: 3.52E-10mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• PKA: 3.00±0.10(Predicted)
• Water Solubility: Soluble in DMF. Insoluble in water.
• BRN: 4327336
• CAS DataBase Reference: Boc-O-tert-butyl-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-O-tert-butyl-L-tyrosine(47375-34-8)
• EPA Substance Registry System: Boc-O-tert-butyl-L-tyrosine(47375-34-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 47375-34-8(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

N-Boc-O-tert-butyl-L-tyrosine is used as pharmaceutical intermediate.

InChI:InChI=1/C18H27NO5/c1-17(2,3)23-13-9-7-12(8-10-13)11-14(15(20)21)19-16(22)24-18(4,5)6/h7-10,14H,11H2,1-6H3,(H,19,22)(H,20,21)/t14-/m0/s1

Upstream product

• 24424-95-1 di-tert-butyl tricarbonate 
• 4727-00-8 O-t-Butyl-L-tyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 94664-23-0 p-nitrophenyl ester of N-tert-butoxycarbonyl-O-tert-butyl-L-tyrosine 
• 58822-25-6 Leu-enkephalin 
• 71921-21-6 Boc-Tyr(But)-Gly-Gly-Phe-OMe 
• 121773-06-6 (S)-2-{(R)-1-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionyl]-6-oxo-1,7-diaza-spiro[4.4]non-7-yl}-3-(4-tert-butoxy-phenyl)-propionic acid methyl ester 
• 129778-99-0 Boc-L-Tyr(Bu^t)-OCO₂Buⁱ 
• 113132-82-4 C₇₆H₁₀₄N₁₄O₂₀S₂ 
• 213688-99-4 (S)-2-{(S)-2-[2-({(1R,2R)-1-tert-Butoxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionyloxy]-cyclohexanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 213688-91-6 (S)-2-{(S)-2-[2-({(1R,2S)-1-tert-Butoxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionyloxy]-cyclohexanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 213688-85-8 (S)-2-{(S)-2-[2-({(1R,2S)-1-tert-Butoxycarbonylamino-2-[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionyloxy]-cyclopentanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid tert-butyl ester 
• 210484-34-7 [(S)-1-(4-tert-Butoxy-benzyl)-2-oxo-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 264921-65-5 [1S-(1α,2α,1'α)]-2-[(2'-[N-(tert-butoxycarbonyl)-L-tyrosine]amino)-1'-(tert-dutyldimethylsiloxy)]ethyl-cyclopropane-1-carboxylic acid methyl ester 
• 289915-16-8 2-[(1-{2-[2-[2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-2-(dimethoxy-phosphoryl)-acetylamino]-ethyl}-cyclopentanecarbonyl)-amino]-hept-6-enoic acid methyl ester 
• 289915-17-9 2-[(1-{2-[2-[2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionylamino]-2-(dimethoxy-phosphoryl)-acetylamino]-ethyl}-cyclopentanecarbonyl)-amino]-oct-7-enoic acid methyl ester 
• 320782-39-6 phenyl tert-butyloxycarbonyl-L-O-tert-butyltyrosyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant articles and documents

Highly selective fluorogenic multianalyte biosensors constructed via enzyme-catalyzed coupling and aggregation-induced emission

The development of a highly selective and fast responsive fluorogenic biosensor for diverse analytes ranging from bioactive small molecules to specific antigens is highly desirable but remains a considerable challenge. We herein propose a new approach by integrating substrate-selective enzymatic reactions with fluorogens exhibiting aggregation-induced emission feature. Tyrosine-functionalized tetraphenylethene, TPE-Tyr, molecularly dissolves in aqueous media with negligible fluorescence emission; upon addition of horseradish peroxidase (HRP) and H2O2, effective cross-linking occurs due to HRP-catalyzed oxidative coupling of tyrosine moieties in TPE-Tyr. This leads to fluorescence emission turn-on and fast detection of H2O2 with high sensitivity and selectivity. As a validation of the new strategy's generality, we further configure it into the biosensor design for glucose through cascade enzymatic reactions and for pathologically relevant antigens (e.g., human carcinoembryonic antigen) by combining with the ELISA kit.

Peptide Synthesis. Part 3. Comparative Solid-phase Syntheses of Human β-Endorphin on Polyamide Supports using t-Butoxycarbonyl and Fluorenylmethoxycarbonyl Protecting Groups

Solid-phase syntheses of the 31 residue peptide human β-endorphin on polar polyamide supports are described.Minimisation of acidic reaction conditions by replacement of the customary t-butoxycarbonyl and benzyl-based protecting groups by fluorenylmethoxyc