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4751-46-6

Tramadol Impurity A, also known as 2-(Dimethylamino)-1-(3-methoxyphenyl)propan-1-ol, is a chemical compound that is an impurity found in the synthesis of the pharmaceutical drug Tramadol. Tramadol is an opioid analgesic used to treat moderate to severe pain. Impurity A is a byproduct of the manufacturing process and is considered a potential contaminant. It is important to monitor and control the levels of such impurities in pharmaceutical products to ensure safety and efficacy. The presence of impurities can affect the drug's performance and may pose health risks if not properly managed.

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  • 4751-46-6 Structure

  • Basic information

    1. Product Name: TRAMAZOLINE IMPURITY A
    2. Synonyms: TRAMAZOLINE IMPURITY A;N-(Naphthalen-1-yl)-4,5-dihydro-1H-imidazol-2-amine
    3. CAS NO:4751-46-6
    4. Molecular Formula: C13H13N3
    5. Molecular Weight: 211.26242
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4751-46-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 377.6°Cat760mmHg
    3. Flash Point: 182.2°C
    4. Appearance: /
    5. Density: 1.23g/cm3
    6. Vapor Pressure: 6.66E-06mmHg at 25°C
    7. Refractive Index: 1.673
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: TRAMAZOLINE IMPURITY A(CAS DataBase Reference)
    11. NIST Chemistry Reference: TRAMAZOLINE IMPURITY A(4751-46-6)
    12. EPA Substance Registry System: TRAMAZOLINE IMPURITY A(4751-46-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4751-46-6(Hazardous Substances Data)

4751-46-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4751-46-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,5 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4751-46:
(6*4)+(5*7)+(4*5)+(3*1)+(2*4)+(1*6)=96
96 % 10 = 6
So 4751-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H13N3/c1-2-6-11-10(4-1)5-3-7-12(11)16-13-14-8-9-15-13/h1-7H,8-9H2,(H2,14,15,16)

4751-46-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000065)  Tramazoline impurity A  European Pharmacopoeia (EP) Reference Standard

  • 4751-46-6

  • Y0000065

  • 1,880.19CNY

  • Detail

4751-46-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-naphthalen-1-yl-4,5-dihydro-1H-imidazol-2-amine

1.2 Other means of identification

Product number -
Other names 2-(1-Naphthylamino)-2-imidazoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4751-46-6 SDS

4751-46-6Downstream Products

4751-46-6Relevant articles and documents

Method for treating central nervous system disorders with substituted 2-imidazoline derivatives

-

Page/Page column 7, (2008/06/13)

The present invention relates to a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders which comprises administering to an individual a therapeutically effective amount of a compound of formula I wherein R, X, A, and n are as defined in the specification and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers and tautomeric forms thereof.

O-Ethyl Thiocarbamates. A Convenient Route to 2-Aryliminoimidazolidines

Reynaud, Pierre,Brion, Jean-Daniel,Davrinche, Catherine,Phan-Chi-Dao

, p. 1789 - 1792 (2007/10/02)

The reaction of N-aryl thionocarbamates and ethylenediamine lead to the corresponding 2-aryliminoimidazolidines, whose structure in pharmacology is well known.But, the behaviour of the N-alkyl thionocarbamates is quite different under operative conditions and these compounds afford with ethylenediamine, to 2-(2'-aminoethylamino)-Δ2-imidazoline, according to a mechanism which is discussed.

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