4876-14-6

Basic information

• Product Name: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride
• Synonyms: 2-AMINO-3-[2(1H)-QUINOLINON-4-YL]-PROPINONIC ACID HCL;2-AMINO-3-(2-OXO-1,2-DIHYDROQUINOLIN-4-YL)PROPIONIC ACID HYDROCHLORIDE;3-(1,2-DIHYDRO-2-OXO-QUINOLINE-4-YL)ALANINE HYDROCHLORIDE;2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionicacidHCl;2-AMINO-3-[2(1H)-QUINOLINON-4-YL]PROPANOIC ACID HYDROCHLORIDE;2-Amino-3-[2(1H)-Quinolinon-4-Yl]Propanoic Acid HCl;2-amino-3-[2(1H)-quinolinon-4-yl]propionic acid HCl;A-AMINO-1,2-DIHYDRO-2-OXO-4-QUINOLINE PROPANOIC ACID
• CAS NO: 4876-14-6
• Molecular Formula: C₁₂H₁₂N₂O₃*ClH
• Molecular Weight: 268.7
• EINECS: 1533716-785-6
• Product Categories: Rebamipide
• Mol File: 4876-14-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 220-221 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(4876-14-6)
• EPA Substance Registry System: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(4876-14-6)

Safety Data

• Hazardous Substances Data: 4876-14-6(Hazardous Substances Data)

Usage

General Description

DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is a chemical compound that is commonly used in pharmaceutical research and development. It is a hydrochloride salt of the amino acid derivative 3-(1,2-dihydro-2-oxo-quinoline-4-yl)alanine, and it has potential applications in the treatment of various diseases and conditions. DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is a synthetic derivative of quinoline, a heterocyclic organic compound, and alanine, a non-essential amino acid. Its unique chemical structure and properties make it an important target for further studies and investigations in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C12H12N2O3.ClH/c13-9(12(16)17)5-7-6-11(15)14-10-4-2-1-3-8(7)10;/h1-4,6,9H,5,13H2,(H,14,15)(H,16,17);1H/t9-;/m0./s1

Upstream product

• 132210-24-3 2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride 
• 4876-10-2 4-bromomethyl-2(1H)-quinolinone 
• 4900-38-3 2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester 

Downstream Products

• 90098-05-8 2-(3-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid 
• 90098-06-9 2-(2-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid 
• 90098-16-1 2-(4-Methyl-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-43-4 2-(4-Methoxy-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-08-1 2-(3,4-Dichloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-10-5 2-(4-Amino-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-24-1 2-[2-(4-Chloro-phenyl)-acetylamino]-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-04-7 rebamipide 
• 90098-38-7 methyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate 
• 103702-42-7 methyl 2-(4-chlorobenzylamino)-3-<2(1H)-quinolinon-4-yl>propionate 
• 90098-41-2 2-(4-Chloro-benzoylamino)-3-(2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-propionic acid 
• 90098-92-3 2-(4-chlorobenzylamino)-3-<2(1H)-quinolinon-4-yl>propionic acid 
• 90098-42-3 2-(4-Bromo-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-33-2 2-(4-chlorobenzenesulfonylamino)-3-<2-(1H)-quinolinon-4-yl>propionic acid 

Relevant articles and documents

Preparation method of rebamipide bulk drug

The invention discloses a preparation method of a rebamipide bulk drug. The preparation method comprises the following steps: 1, preparing a crude product of the rebamipide bulk drug: preparing the crude product of the rebamipide bulk drug by utilizing a compound III and 4-chlorobenzoyl chloride; and 2, purifying the rebamipide bulk drug. The compound III is prepared from a compound II, deionized water and concentrated hydrochloric acid, the compound II is prepared from a compound I, glacial acetic acid and concentrated hydrochloric acid, and the compound I is prepared from diethyl acetamidomalonate and 4-bromomethylquinolone. A process control method is utilized, impurities in the synthesized compound I, impurities in the synthesized compound II and impurities in the synthesized compound III are respectively subjected to impurity removal and purification by a common purification method, and the purity of the rebamipide bulk drug is improved in combination with a method for crystallizing and purifying the crude product of the rebamipide bulk drug.