4876-14-6

Basic information

• Product Name: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride
• Synonyms: 2-AMINO-3-[2(1H)-QUINOLINON-4-YL]-PROPINONIC ACID HCL;2-AMINO-3-(2-OXO-1,2-DIHYDROQUINOLIN-4-YL)PROPIONIC ACID HYDROCHLORIDE;3-(1,2-DIHYDRO-2-OXO-QUINOLINE-4-YL)ALANINE HYDROCHLORIDE;2-Amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionicacidHCl;2-AMINO-3-[2(1H)-QUINOLINON-4-YL]PROPANOIC ACID HYDROCHLORIDE;2-Amino-3-[2(1H)-Quinolinon-4-Yl]Propanoic Acid HCl;2-amino-3-[2(1H)-quinolinon-4-yl]propionic acid HCl;A-AMINO-1,2-DIHYDRO-2-OXO-4-QUINOLINE PROPANOIC ACID
• CAS NO: 4876-14-6
• Molecular Formula: C₁₂H₁₂N₂O₃*ClH
• Molecular Weight: 268.7
• EINECS: 1533716-785-6
• Product Categories: Rebamipide
• Mol File: 4876-14-6.mol

Chemical Properties

• Melting Point: 220-221 °C
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(4876-14-6)
• EPA Substance Registry System: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride(4876-14-6)

Safety Data

• Hazardous Substances Data: 4876-14-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is utilized as a research compound for the development of new drugs and therapies. Its unique structure and properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is used as a key intermediate in the synthesis of novel compounds with potential therapeutic applications. Its ability to be modified and combined with other molecules allows for the exploration of new chemical entities with improved pharmacological profiles.
Used in Drug Discovery:
DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is employed as a starting material in drug discovery processes. Its potential applications in the treatment of various diseases make it an important compound for screening and optimization to identify new lead compounds and drug candidates.
Used in Chemical Synthesis:
DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride is also used in chemical synthesis for the preparation of other quinoline-based derivatives with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C12H12N2O3.ClH/c13-9(12(16)17)5-7-6-11(15)14-10-4-2-1-3-8(7)10;/h1-4,6,9H,5,13H2,(H,14,15)(H,16,17);1H/t9-;/m0./s1

Upstream product

• 132210-24-3 2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride 
• 4900-38-3 2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester 
• 4876-10-2 4-bromomethyl-2(1H)-quinolinone 

Downstream Products

• 90098-16-1 2-(4-Methyl-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-38-7 methyl 2-(4-chlorobenzoylamino)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionate 
• 103702-42-7 methyl 2-(4-chlorobenzylamino)-3-<2(1H)-quinolinon-4-yl>propionate 
• 90098-41-2 2-(4-Chloro-benzoylamino)-3-(2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-propionic acid 
• 90098-92-3 2-(4-chlorobenzylamino)-3-<2(1H)-quinolinon-4-yl>propionic acid 
• 90098-24-1 2-[2-(4-Chloro-phenyl)-acetylamino]-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-42-3 2-(4-Bromo-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-10-5 2-(4-Amino-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-08-1 2-(3,4-Dichloro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-33-2 2-(4-chlorobenzenesulfonylamino)-3-<2-(1H)-quinolinon-4-yl>propionic acid 
• 90098-09-2 2-(4-Nitro-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-43-4 2-(4-Methoxy-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 
• 90098-04-7 rebamipide 
• 90098-03-6 2-Benzoylamino-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid 

Relevant articles and documents

Preparation method of rebamipide bulk drug

The invention discloses a preparation method of a rebamipide bulk drug. The preparation method comprises the following steps: 1, preparing a crude product of the rebamipide bulk drug: preparing the crude product of the rebamipide bulk drug by utilizing a compound III and 4-chlorobenzoyl chloride; and 2, purifying the rebamipide bulk drug. The compound III is prepared from a compound II, deionized water and concentrated hydrochloric acid, the compound II is prepared from a compound I, glacial acetic acid and concentrated hydrochloric acid, and the compound I is prepared from diethyl acetamidomalonate and 4-bromomethylquinolone. A process control method is utilized, impurities in the synthesized compound I, impurities in the synthesized compound II and impurities in the synthesized compound III are respectively subjected to impurity removal and purification by a common purification method, and the purity of the rebamipide bulk drug is improved in combination with a method for crystallizing and purifying the crude product of the rebamipide bulk drug.