DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride

Base Information

• Chemical Name: DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride
• CAS No.: 4876-14-6
• Molecular Formula: C12H11N2O3^.HCl
• Molecular Weight: 268.7
• Hs Code.: 2933499090
• Mol file: 4876-14-6.mol

Synonyms:4-Quinolinepropanoic acid, a-amino-1,2-dihydro-2-oxo-,monohydrochloride (9CI);2-Amino-3-(2-quinolon-4-yl)propionic acidhydrochloride;

Chemical Property of DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride

Chemical Property:

• Melting Point: 220-221 °C
• Boiling Point: 522.7oC at 760mmHg
• Flash Point: 269.9oC
• PSA: 96.18000
• LogP: 1.98480
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propionicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride

There total 4 articles about DL-3-(1,2-Dihydro-2-oxo-quinoline-4-yl)alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester (4900-38-3) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

With hydrogenchloride; for 9h; Heating;

DOI:10.1248/cpb.33.3775

Reference yield:

2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride (132210-24-3) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

With hydrogenchloride; In water; at 105 ℃;

Reference yield:

4-bromomethyl-2(1H)-quinolinone (4876-10-2) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / sodium / ethanol / 2 h

2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating

With hydrogenchloride; sodium; In ethanol;

DOI:10.1248/cpb.33.3775

upstream raw materials:

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

4-bromomethyl-2(1H)-quinolinone

2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride

Downstream raw materials:

2-(4-Hydroxy-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid

2-(4-Methoxy-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid

2-(4-chlorobenzenesulfonylamino)-3-<2-(1H)-quinolinon-4-yl>propionic acid

2-(4-Bromo-benzoylamino)-3-(2-oxo-1,2-dihydro-quinolin-4-yl)-propionic acid

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