49545-70-2

Basic information

• Product Name: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one
• Synonyms: 2-(4-Chlorophenylmethylene)-1-tetralone
• CAS NO: 49545-70-2
• Molecular Formula: C₁₇H₁₃ClO
• Molecular Weight: 268.7375
• Mol File: 49545-70-2.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 431.7°C at 760 mmHg
• Flash Point: 239.7°C
• Density: 1.264g/cm³
• Vapor Pressure: 1.17E-07mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(49545-70-2)
• EPA Substance Registry System: 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one(49545-70-2)

Safety Data

• Hazardous Substances Data: 49545-70-2(Hazardous Substances Data)

Usage

Molecular Structure

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one consists of a complex structure that includes a chlorobenzylidene group (a benzylidene group with a chlorine atom attached to the benzene ring) and a dihydronaphthalenone group (a naphthalenone group with two additional carbon atoms forming a six-membered ring).

Common Uses

This chemical compound is commonly used in the synthesis of pharmaceuticals and agrochemicals.

Potential Applications

2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one has potential applications as an intermediate for the production of various drugs and agricultural chemicals.

Chemical Reactivity

The compound has a versatile chemical structure and reactivity, making it useful in the synthesis of various products.

Safety Precautions

It is important to handle and use this compound with caution due to its potential for toxic and hazardous properties.

Further Research

More research and development is needed to explore the potential uses and applications of 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one in various industries.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 62085-79-4 2-(4-chlorobenzyl)-3,4-dihydro-2H-naphthalen-1-one 
• 49545-70-2 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one 
• 1628798-71-9 7,9-bis(4-chlorophenyl)-6,7-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazoline 
• 42478-33-1 3'-(p-chlorophenyl)-spiro[1,2,3,4-tetrahydronaphthalene-2,2'-oxirane]-1-one 
• 128483-26-1 2-Mercapto-4-p-chlorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Arylidene-Substituted Chromanones and Tetralones Catalyzed by Noyori-Ikariya Ru(II) Complexes: One-Pot Reduction of C═C and C═O bonds

3-Arylidenechroman-4-ones and 2-arylidene-1-tetralones are hydrogenated to cis-benzylic alcohols in dr's and er's up to 99:1 via a C═C and C═O one-pot reduction in the presence of 2-5 mol % Noyori-Ikariya-type RuII chiral complexes and HCO2Na as a hydroge

Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of α,α′-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones

Abstract: α,α′-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET techniques. The analysis revealed that the present catalyst has basic sites which promote the synthesis of desired products. The main attractions of our protocol are utilization of highly abundant bio-waste-derived catalyst and good-to-excellent yield in shortest reaction time. This green protocol was further extended for structurally diverse 2-arylidene-1-tetralones by condensation of equimolar quantity of aromatic aldehydes and 1-tetralone at low temperature. The catalyst could be quantitatively recovered and reused effectively for five times. Graphic abstract: [Figure not available: see fulltext.].

I2/TBHP mediated diastereoselective synthesis of spiroaziridines

Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.