49628-34-4

Basic information

• Product Name: 2-thiothenoic acid
• Synonyms: 2-thiothenoic acid;2-Thiophenecarbothioic acid
• CAS NO: 49628-34-4
• Molecular Formula: C₅H₄OS₂
• Molecular Weight: 148.20336
• EINECS: 256-404-4
• Mol File: 49628-34-4.mol

Chemical Properties

• Boiling Point: 235.2°Cat760mmHg
• Flash Point: 96°C
• Appearance: /
• Density: 1.335g/cm³
• Vapor Pressure: 0.051mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2-thiothenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-thiothenoic acid(49628-34-4)
• EPA Substance Registry System: 2-thiothenoic acid(49628-34-4)

Safety Data

• Hazardous Substances Data: 49628-34-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H4OS2/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)

Upstream product

• 5271-67-0 2-Thiophenecarbonyl chloride 
• 527-72-0 2-thiophenylcarboxylic acid 

Downstream Products

• 1197823-47-4 Mo₂(2,4,6-triisopropylbenzoate)2(2-thienylthiocarboxylate)2 
• 1197823-48-5 W₂(2,4,6-triisopropylbenzoate)2(2-thienylthiocarboxylate)2 
• 1352080-68-2 H[(triphenylphosphine)2Cu(thiophene-2-thiocarboxylate)2] 

Relevant articles and documents

Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin

Nitrosporeusines A and B are two recently isolated marine natural products with novel skeleton and exceptional biological profile. Interesting antiviral activity of nitrosporeusines and promising potential in curing various diseases, evident from positive data from various animal models, led us to investigate their anti-inflammatory potential. Accordingly, we planned and synthesized nitrosporeusines A and B in racemic as well as enantiopure forms. The natural product synthesis was followed by preparation of several analogues, and all the synthesized compounds were evaluated for in vitro and in vivo anti-inflammatory potential. Among them, compounds 25, 29 and 40 significantly reduced levels of nitric oxide (NO), reactive oxygen species (ROS) and pro-inflammatory cytokines. In addition, these compounds suppressed several pro-inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), and thereby can be emerged as potent anti-inflammatory compounds. Furthermore, all possible isomers of lead compound 25 were synthesized, characterized and profiled in same set of assays and found that one of the enantiomer (?)-25a was superior among them.

Synthesis and structural studies of organotin(IV) and organolead(IV) thiophene-2-thiocarboxylate

A few organotin(IV) ([R2SnCl2], [R3SnCl]; R = Me, Ph, nPr, or nBu) and organolead(IV) ([Ph2PbCl2], [Ph3PbCl]) compounds that contain the thiophene-2-thiocarboxylate ligand have been synthesized and characterized by 1H, 13C, 119Sn NMR; FTIR; and UV/Vis spectroscopy. The molecular structures of some of the compounds were studied by single-crystal X-ray diffraction. Structures and electronic transitions have been explained on the basis of DFT calculations. Organotin ([R2SnCl2], [R3SnCl]; R = Me, Ph, nPr, and nBu) and organolead ([Ph2PbCl2], [Ph3PbCl]) compounds that contain the thiophene-2-thiocarboxylate ligand have been synthesized and characterized by spectral and crystallographic studies. Structures and electronic transitions have been explained on the basis of DFT calculations.

ACYLSULFENIC ACIDS

The synthesis of acylsulfenic acids and esters, their properties, reactions and spectral characteristics are described.