4985-46-0

Basic information

• Product Name: H-TYR-NH2 HCL
• Synonyms: (S)-2-AMino-3-(4-hydroxyphenyl)propanaMide;H-Tyr-NH2 Hydrochloride;(alphaS)-alpha-Amino-4-hydroxybenzenepropanamide;L-Tyr-NH2;L-Tyrosine amide≥ 98% (HPLC);TYROSINE-NH2;TYROSINE-NH2 HCL;TYROSINAMIDE
• CAS NO: 4985-46-0
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 216.66
• Product Categories: Amino Acids;I - Z;Modified Amino Acids
• Mol File: 4985-46-0.mol

Chemical Properties

• Melting Point: 153.5°C
• Boiling Point: 313.03°C (rough estimate)
• Flash Point: 218.5 °C
• Appearance: /
• Density: 1.1819 (rough estimate)
• Vapor Pressure: 2.84E-08mmHg at 25°C
• Refractive Index: 1.5373 (estimate)
• Storage Temp.: -15°C
• PKA: 9.97±0.15(Predicted)
• CAS DataBase Reference: H-TYR-NH2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-TYR-NH2 HCL(4985-46-0)
• EPA Substance Registry System: H-TYR-NH2 HCL(4985-46-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 4985-46-0(Hazardous Substances Data)

Usage

Uses

Used in Biosensor Development:
H-TYR-NH2 HCL is used as a chiral ligand for the in vitro selection of DNA aptamers, which are crucial for the development of aptamer-based biosensors. These biosensors have a wide range of applications, including medical diagnostics, environmental monitoring, and food safety testing.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, H-TYR-NH2 HCL serves as a building block for the synthesis of various pharmaceutical compounds. Its unique chemical properties make it a valuable component in the development of new drugs and therapies.
Used in Research and Development:
H-TYR-NH2 HCL is also used as a research tool in various scientific fields, including biochemistry, molecular biology, and materials science. Its role as a chiral ligand allows researchers to study the interactions between biomolecules and develop a deeper understanding of biological processes.
Used in Chemical Synthesis:
As a tyrosine derivative, H-TYR-NH2 HCL is employed in the chemical synthesis of various compounds, including peptides, proteins, and other bioactive molecules. Its versatility as a building block makes it a valuable asset in the synthesis of complex molecular structures.

InChI:InChI=1/C9H12N2O2/c10-8(9(11)13)5-6-1-3-7(12)4-2-6/h1-4,8,12H,5,10H2,(H2,11,13)/t8-/m0/s1

Upstream product

• 60-18-4 L-tyrosine 
• 556-02-5 ?Tyr 
• 34081-17-9 tyrosine ethyl ester 
• 1080-06-4 L-Tyr-OMe 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 101469-25-4 tyrosinamide 

Downstream Products

• 116055-06-2 N-trichloroacetyl-L-tyrosine amide 
• 7377-01-7 N-ethoxycarbonyl-L-tyrosine amide 
• 7376-98-9 N-chloroacetyl-L-tyrosine amide 
• 15985-84-9 N-phenylthioacetyl-L-tyrosine amide 
• 17193-61-2 (N-Benzyloxycarbonyl-β-O-t-butyl-Asp)-Tyr-amid 
• 78700-70-6 N-Boc-L-tyrosyl-D-alanyl-L-phenylalanyl-glycyl-L-tyrosine amide 
• 14191-95-8 4-cyanomethylphenol 
• 48179-76-6 (S)-2-amino-3-(4-hydroxyphenyl)-N-phenylpropanamide 
• 119153-84-3 Bz-Tyr-Tyr-NH₂ 
• 95311-14-1 (S)-N-[(S)-1-Carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-2-(2-nitro-phenylsulfanylamino)-propionamide 
• 114519-10-7 N-(N-benzyloxycarbonyl-L-seryl)-L-tyrosine amide 
• 22839-98-1 N-Benzyloxcarbonyl-β-O-benzyl-Asp-Tyr-amid 
• 15985-81-6 N-thiobenzoyl-L-tyrosine amide 
• 7376-99-0 N-trifluoroacetyl-L-tyrosine amide 

Relevant articles and documents

Synthesis of aromatic amino acid amides

Aromatic amino esters, in toluene or water, react with aqueous ammonium hydroxide to give moderate to high yields of the corresponding amides.

HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION

The invention pertains to the synthesis, isolation, and characterization of hemiaminal for selective labeling of peptides, proteins, antibodies, and organic fragments with -C(=0) CH2NH2 and derivatives with -CH2NH2 group over -C(=0) CHRNH2 group (where R≠H). The invention also pertains to the method of single-site immobilization of proteins through N-terminus Gly on solid phase. The invention includes late-stage tagging of N-terminus Gly with an affinity tag, 19F NMR probe, and a fluorophore and a method for metal-free protein purification and isolation of analytically pure proteins.

Synthetic method for chiral alpha-aminoamide compounds

The invention provides a synthetic method for chiral alpha-aminoamide compounds, belongs to the technical field of organic synthetic methodology, and concretely relates to a synthetic method for chiral alpha-aminoamide compounds, wherein the method has a simple process, low costs and good economy. The method comprises the following steps: 1, performing ammonolysis: adding substituted chiral alpha-aminocarboxylate hydrochloride into concentrated ammonia water, performing stirring for 4-12h under a room temperature, wherein each 1mmol substituted chiral alpha-aminocarboxylate hydrochloride is corresponding to 2-8mL the concentrated ammonia water; 2, after a reaction is finished, performing distillation for removing ammonia water after the reaction to obtain crude products chiral alpha-aminoamide compounds; and 3, performing filtration on the obtained crude products chiral alpha-aminoamide compounds by adopting a manner of adding a solvent or performing purification on the obtained crude products chiral alpha-aminoamide compounds through a manner of column chromatography which uses ammonia water as a mobile phase to obtain the products chiral alpha-aminoamide compounds. Compared with the prior art, a large number of an ammonia gas for ammonolysis is not needed in the method, the process and post-treatment are simple, costs are low and reaction time is short.

Imaging of Enzyme Activity

This invention relates to biochemistry and magnetic resonance imaging.

Process for producing optically active alpha-amino acid and optically active alpha-amino acid amine

The present invention provides a process for efficiently producing an optically active α-amino acid and an optically active α-amino acid amide. After contacting with cells or processed cells thereof having an ability to asymmetrically hydrolyse, a water solvent is substituted with at least one solvent selected from the group consisting of linear, branched, or cyclic alcohol having 3 or more carbon atoms and the optically active α-amino acid is preferentially precipitated from the alcohol solution. The addition of basic compounds, particularly potassium compounds to the alcohol solution containing the optically active α-amino acid amide, which is obtained after the separation of the optically active α-amino acid, enables the purification of the amide without the inclusion of amino acid into amino acid amide. Thus, the amide is subjected to the step of racemization and then recycled.

Chelating agents and method

A simple method for making EDTA, ED3A or DTPA analogs from amide derivatives of alpha amino acids is disclosed. These EDTA, ED3A or DTPA analogs are useful chelating agents, and preferably are useful as bifunctional chelating agents which may be attached to biological molecules and which form physiologically stable chelates with a variety of metal ions.