48179-76-6Relevant academic research and scientific papers
Synthesis of chiral α-amino anilides via a DMEDA-promoted selective C─N coupling reaction of aryl halides and α-aminoamides
Min, Xiangting,Li, Xiaoyu,Wang, Yu,Dong, Yawen,Tang, Jingjing,Wang, Jing,Liu, Jianhui
, p. 2561 - 2566 (2018)
A DMEDA-promoted and copper-catalyzed approach has been designed for the coupling of aryl halides and chiral α-aminoamides to afford a range of functionalized chiral α-amino anilides. This method has a higher yield and better reproducibility than those under ligand-free conditions. Of the two amino groups in the same molecule, only the amide NH2 is observed to react, showing high regioselectivity. In addition, no racemization occurs, and the ee can reach 99%. For certain hydroxyl-containing substrates, such as L-tyrosine amide and L-threonine amide, addition of a phase transfer catalyst (15-Crown-5) is necessary for such a transformation.
Synthetic process of chiral N-aromatic amino acid amide
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Paragraph 0010; 0014, (2016/10/17)
Chiral N-aromatic amino acid amide is a core structure fragment of drugs and an intermediate of the drugs. Only if the chiral structure of the product is not required by special raw materials such aryl halide activated by functional groups of nitryl and t
A molecularly imprinted polymer for the reconstruction of a molecular recognition region
Murakami, Sachiko,Yamamoto, Ken-Ichi,Shinmori, Hideyuki,Takeuchi, Toshifumi
experimental part, p. 1028 - 1029 (2009/12/02)
Cofactor-binding protein mimics were prepared by metallo-porphyrin-based covalent molecular imprinting of amino acid derivatives, where an apo-type scaffold was obtained by removing the template and the porphyrin moieties from the resulting polymer after the imprinting process, and when the porphyrin derivative was incorporated as the cofactor to yield the holo-type binding sites, enantioselectivity was induced and the chirality of the target amino acids was recognized. Copyright
