500701-14-4Relevant articles and documents
Method for synthesizing N-alkyl-N-aryl (methyl) acrylamide double-tail hydrophobic monomer
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Paragraph 0029; 0030, (2019/10/01)
The invention discloses a method for synthesizing an N-alkyl-N-aryl (methyl) acrylamide double-tail hydrophobic monomer. The method comprises the following steps: (1) putting alkylamine into a methanol solution with aromatic aldehyde, increasing the temperature till backflow, and performing a reaction over night; reducing the temperature of the mixed liquid to 5 DEG C or lower, adding a small amount of sodium borohydride for multiple times, removing an ice water bath, continuously performing a reaction for 30-120 minutes, and performing a backflow reaction for 3-6 hours; adding a certain amount of water to quench the reaction, drying an organic phase, and performing rotational evaporation so as to remove a solvent so as to obtain N-aryl-N-alkylamine; and (2) dissolving the N-aryl-N-alkylamine by using dichloromethane, adding a NaOH solution, slowly dropping a dichloromethane solution of (methyl) acryloyl chloride under a stirring condition of the ice water bath, performing heating to the room temperature, continuously performing a reaction for 2-12 hours, washing an organic layer till neutral by using distilled water, and further performing drying and rotational evaporation, so asto obtain N-alkyl-N-aryl (methyl) acrylamide. The method is gentle in reaction condition, short in reaction time, high in yield and applicable to large-scale industrial application.
