50424-93-6

Basic information

• Product Name: 3-methyl-2-nitrobenzoyl chloride
• Synonyms: 3-methyl-2-nitrobenzoyl chloride
• CAS NO: 50424-93-6
• Molecular Formula: C₈H₆ClNO₃
• Molecular Weight: 199.592
• Mol File: 50424-93-6.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 160°C (rough estimate)
• Flash Point: 141.5°C
• Appearance: /
• Density: 1.4125 (rough estimate)
• Vapor Pressure: 0.0006mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 3-methyl-2-nitrobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-2-nitrobenzoyl chloride(50424-93-6)
• EPA Substance Registry System: 3-methyl-2-nitrobenzoyl chloride(50424-93-6)

Safety Data

• Hazardous Substances Data: 50424-93-6(Hazardous Substances Data)

Usage

General Description

3-Methyl-2-nitrobenzoyl chloride is a chemical compound with the molecular formula C8H6ClNO4. It is a yellow solid that is commonly used in organic synthesis as a building block for the preparation of various organic compounds. It is classified as an acyl chloride, and is used as a reagent in the synthesis of pharmaceuticals and agrochemicals. 3-Methyl-2-nitrobenzoyl chloride is also used as a key intermediate in the synthesis of dyes, pigments, and other organic materials. Additionally, it is an important chemical reagent in the research and development of new materials and chemical processes.

InChI:InChI=1/C8H6ClNO3/c1-5-3-2-4-6(8(9)11)7(5)10(12)13/h2-4H,1H3

Upstream product

• 99-04-7 m-Toluic acid 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 

Downstream Products

• 100230-78-2 (2S)-N-(3-methyl-2-nitrobenzoyl)proline 
• 626606-15-3 4-methyl-2-(3-methyl-2-nitrophenyl)-1H-benzimidazole 
• 4389-45-1 3-methylantranilic acid 
• 83334-85-4 methyl 3-methyl-N-methyl-N-<3-methyl-N-(3-methyl-2-nitrobenzoyl)anthraniloyl>anthranilate 
• 83325-80-8 3-methyl-N-methyl-N-<3-methyl-N-(3-methyl-2-nitrobenzoyl)anthraniloyl>anthranilic acid 
• 5437-38-7 3-methyl-2-nitrobenzoic acid 
• 78876-98-9 3-methyl-N-(3-methyl-2-nitrobenzoyl)anthranilic acid 
• 87693-24-1 3-methyl-2-nitro-N-1H-tetrazol-5-ylbenzamide 
• 111460-98-1 (5-Hydroxy-3-methyl-isoxazol-4-yl)-(3-methyl-2-nitro-phenyl)-methanone 
• 109407-83-2 N,3-dimethyl-2-nitro-N-phenylbenzamide 
• 110179-17-4 3-methyl-2-nitro-benzoic acid anilide 
• 5471-82-9 methyl 3-methyl-2-nitrobenzoate 

Relevant articles and documents

N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF

The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R1 is selected from halo or C1-C3 alkyl; R2

Rh(iii)-catalyzed diastereoselective cascade annulation of enone-tethered cyclohexadienonesviaC(sp2)-H bond activation

Herein, we report highly diastereoselective arylative cyclization of enone-tethered cyclohexadienonesviaRh(iii)-catalyzed C-H activation ofN-methoxybenzamides. This reaction proceeds through the formation of a five-membered rhodacycle followed by bis-Michael cascade annulation to access functionalized bicyclic scaffolds with four contiguous stereocenters with a broad substrate scope. These products have excellent functional handles, allowing further synthetic transformation to increase the structural complexity. Furthermore, mechanistic studies of arylative cyclization and a gram-scale experiment are also presented.

PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

The present application relate to a process for preparation of 4-methylene tetrahydrofuran compound of formula II, which is useful as an intermediate for the preparation of halichondrin B analogues such as eribulin and its pharmaceutically acceptable salts thereof. The present application also provide crystalline compound of formula III and crystalline compound of formula II.