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2-Bromo-4-(tert-butyl)pyridine is an aromatic tertiary amine characterized by a pyridine ring, which is a six-membered aromatic ring with a nitrogen atom. 2-Bromo-4-(tert-butyl)pyridine is further substituted with a bromine atom and a tert-butyl group at positions 2 and 4 respectively. It is commonly used as a starting material or intermediate in organic synthesis, allowing for the creation of more complex chemical structures. The properties of this compound, such as melting point, boiling point, and specific rotation, can vary depending on specific conditions and may not be known. Due to its nature as an organic compound, care must be taken in handling 2-Bromo-4-(tert-butyl)pyridine to avoid potential health hazards.

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  • 50488-34-1 Structure
  • Basic information

    1. Product Name: 2-Bromo-4-(tert-butyl)pyridine
    2. Synonyms: 2-Bromo-4-(tert-butyl)pyridine
    3. CAS NO:50488-34-1
    4. Molecular Formula: C9H12BrN
    5. Molecular Weight: 214.10228
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 50488-34-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 243.638 °C at 760 mmHg
    3. Flash Point: 101.149 °C
    4. Appearance: /
    5. Density: 1.293 g/cm3
    6. Vapor Pressure: 0.0495mmHg at 25°C
    7. Refractive Index: 1.521
    8. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    9. Solubility: N/A
    10. PKA: 1.50±0.10(Predicted)
    11. CAS DataBase Reference: 2-Bromo-4-(tert-butyl)pyridine(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-Bromo-4-(tert-butyl)pyridine(50488-34-1)
    13. EPA Substance Registry System: 2-Bromo-4-(tert-butyl)pyridine(50488-34-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 50488-34-1(Hazardous Substances Data)

50488-34-1 Usage

Uses

Used in Organic Synthesis:
2-Bromo-4-(tert-butyl)pyridine is used as a starting material or intermediate for the synthesis of more complex chemical structures. Its unique structure with a pyridine ring, bromine atom, and tert-butyl group allows for various chemical reactions and modifications, making it a valuable component in the development of new compounds and materials.
Used in Pharmaceutical Industry:
2-Bromo-4-(tert-butyl)pyridine is used as a building block in the synthesis of pharmaceutical compounds. Its versatility in organic synthesis enables the creation of potential drug candidates with desired properties, such as improved efficacy, selectivity, or reduced side effects.
Used in Chemical Research:
2-Bromo-4-(tert-butyl)pyridine is used as a research tool in the study of chemical reactions and mechanisms. Its reactivity and structural features make it an interesting subject for exploring new reaction pathways and understanding the behavior of similar compounds in various chemical processes.

Check Digit Verification of cas no

The CAS Registry Mumber 50488-34-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,8 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 50488-34:
(7*5)+(6*0)+(5*4)+(4*8)+(3*8)+(2*3)+(1*4)=121
121 % 10 = 1
So 50488-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12BrN/c1-9(2,3)7-4-5-11-8(10)6-7/h4-6H,1-3H3

50488-34-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-bromo-4-tert-butylpyridine

1.2 Other means of identification

Product number -
Other names 2-bromo-4-tert-butyl-pyridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50488-34-1 SDS

50488-34-1Synthetic route

2-chloro-4-(1,1-dimethylethyl)pyridine
81167-60-4

2-chloro-4-(1,1-dimethylethyl)pyridine

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

Conditions
ConditionsYield
With trimethylsilyl bromide; propiononitrile for 21h; Reflux;100%
With trimethylsilyl bromide for 48h; Reflux;80%
C12H12F6LiNO

C12H12F6LiNO

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

Conditions
ConditionsYield
With 1,2-dibromo-1,1,2,2-tetrachloroethane In tetrahydrofuran; diethyl ether at -107℃;50%
4-tert-butylpyridine
3978-81-2

4-tert-butylpyridine

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

Conditions
ConditionsYield
Stage #1: 4-tert-butylpyridine With n-butyllithium; 2-(N,N-dimethylamino)ethanol at -5℃; for 1h; Inert atmosphere;
Stage #2: With carbon tetrabromide at -78 - 20℃; Inert atmosphere;
45%
Multi-step reaction with 3 steps
1: -78 °C
2: lithium 2,2,6,6-tetramethylpiperidide / tetrahydrofuran; diethyl ether / 1 h / -107 °C
3: 50 percent / (Cl2CBr)2 / tetrahydrofuran; diethyl ether / -107 °C
View Scheme
4-tert-butylpyridine N-oxide
23569-17-7

4-tert-butylpyridine N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

Conditions
ConditionsYield
Stage #1: 4-tert-butylpyridine N-oxide With phosphorus(V) oxybromide In 1,2-dichloro-ethane at 20 - 70℃;
Stage #2: With water; sodium hydroxide In 1,2-dichloro-ethane pH=10; Cooling;
14%
Multi-step reaction with 2 steps
1: trichlorophosphate / 24 h / Reflux
2: trimethylsilyl bromide / 48 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: trichlorophosphate / 20 h / Cooling with ice; Reflux
2: trimethylsilyl bromide; propiononitrile / 21 h / Reflux
View Scheme
C12H13F6NO
87432-73-3

C12H13F6NO

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium 2,2,6,6-tetramethylpiperidide / tetrahydrofuran; diethyl ether / 1 h / -107 °C
2: 50 percent / (Cl2CBr)2 / tetrahydrofuran; diethyl ether / -107 °C
View Scheme
2-bromo-9H-carbazole
3652-90-2

2-bromo-9H-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

2-bromo-9-(4-(tert-butyl)pyridin-2-yl)-9H-carbazole

2-bromo-9-(4-(tert-butyl)pyridin-2-yl)-9H-carbazole

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; copper(l) iodide; lithium tert-butoxide In toluene at 130℃; for 24h; Inert atmosphere;99%
With 1-methyl-1H-imidazole; copper(l) iodide; lithium tert-butoxide In toluene at 130℃; for 24h; Inert atmosphere;99%
With 1-methyl-1H-imidazole; copper(l) iodide; lithium tert-butoxide In toluene at 20 - 130℃; for 48h; Inert atmosphere;99%
With 1-methyl-1H-imidazole; copper(l) iodide; potassium carbonate In toluene at 115 - 125℃; for 96h; Inert atmosphere;96%
With copper(l) iodide; potassium carbonate In toluene at 115 - 125℃; for 96h; Inert atmosphere;96%
6-bromo-2-methoxy-9H-carbazole

6-bromo-2-methoxy-9H-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

C22H21BrN2O

C22H21BrN2O

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine In 1,4-dioxane at 120℃; for 12h;95%
2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole
1393812-51-5

2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy)-9-(4-tert-butylpyridin-2-yl)-9H-carbazole

2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)phenoxy)-9-(4-tert-butylpyridin-2-yl)-9H-carbazole

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In 1,4-dioxane; toluene at 95 - 105℃; for 48h; Inert atmosphere;94%
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In 1,4-dioxane; toluene at 95 - 105℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube;94%
6-tert-butyl-2-methoxycarbazole

6-tert-butyl-2-methoxycarbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

C26H30N2O

C26H30N2O

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; copper(l) chloride; lithium tert-butoxide In toluene at 130℃; for 42h; Inert atmosphere;93%
3-methoxy-N-phenylaniline
101-16-6

3-methoxy-N-phenylaniline

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4-(tert-butyl)-N-(3-methoxyphenyl)-N-phenylpyridin-2-amine

4-(tert-butyl)-N-(3-methoxyphenyl)-N-phenylpyridin-2-amine

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate In toluene for 18h; Reflux;89%
2'-(1H-pyrazol-1-yl)-9H-2,9'-bicarbazole

2'-(1H-pyrazol-1-yl)-9H-2,9'-bicarbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

9-(4-tert-butylpyridin-2-yl)-2'-(1H-pyrazol-1-yl)-9H-2,9'-bicarbazole

9-(4-tert-butylpyridin-2-yl)-2'-(1H-pyrazol-1-yl)-9H-2,9'-bicarbazole

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In 1,4-dioxane; toluene at 95 - 105℃; for 48h; Inert atmosphere;88%
2-(3-(4-phenyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole

2-(3-(4-phenyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

9-(4-tert-butylpyridin-2-yl)-2-(3-(4-phenyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole

9-(4-tert-butylpyridin-2-yl)-2-(3-(4-phenyl-1H-pyrazol-1-yl)phenoxy)-9H-carbazole

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In 1,4-dioxane; toluene at 100 - 110℃; for 39h; Inert atmosphere; Sealed tube;86%
With tris-(dibenzylideneacetone)dipalladium(0); johnphos In 1,4-dioxane; toluene at 100 - 110℃; for 39h; Schlenk technique; Inert atmosphere; Sealed tube;
2-methoxy-9H-carbazole
6933-49-9

2-methoxy-9H-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

C22H22N2O

C22H22N2O

Conditions
ConditionsYield
With potassium phosphate; copper(l) iodide; trans-1,2-cyclohexanediamine In 1,4-dioxane at 120℃; for 12h;85%
With potassium phosphate; copper(l) iodide; rac-diaminocyclohexane In 1,4-dioxane at 120℃; for 18h;80%
2-methoxy-6-methyl-(9H)-carbazole
32550-53-1

2-methoxy-6-methyl-(9H)-carbazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

C23H24N2O

C23H24N2O

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; copper(l) chloride; lithium tert-butoxide In toluene at 130℃; for 24h; Inert atmosphere;80%
2-amino-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide

2-amino-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

2-((4-(tert-butyl)pyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide

2-((4-(tert-butyl)pyridin-2-yl)amino)-N-(2-(2-methyl-1H-indol-3-yl)ethyl)pyrimidine-5-carboxamide

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Inert atmosphere;80%
tert-butyl (4S)-4-[(3Z)-3-tert-butylsulfinyliminopropyl]-2,2-dimethylpyrrolidine-1-carboxylate

tert-butyl (4S)-4-[(3Z)-3-tert-butylsulfinyliminopropyl]-2,2-dimethylpyrrolidine-1-carboxylate

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

tert-butyl (4S)-4-[3-(4-tert-butyl-2-pyridyl)-3-(tert-butylsulfinylamino)propyl]-2,2-dimethylpyrrolidine-1-carboxylate

tert-butyl (4S)-4-[3-(4-tert-butyl-2-pyridyl)-3-(tert-butylsulfinylamino)propyl]-2,2-dimethylpyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(tert-butyl)-2-bromopyridine With n-butyllithium In diethyl ether; hexane at -70℃; for 0.666667h; Inert atmosphere;
Stage #2: tert-butyl (4S)-4-[(3Z)-3-tert-butylsulfinyliminopropyl]-2,2-dimethylpyrrolidine-1-carboxylate In tetrahydrofuran; diethyl ether; hexane at -78 - -40℃; for 0.75h; Inert atmosphere;
79%
4-ethoxycarbonyl-2-(pyridin-2-yl)pyridine N-oxide
1286763-08-3

4-ethoxycarbonyl-2-(pyridin-2-yl)pyridine N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4-tert-butyl-4'-ethoxycarbonyl-2,2':6',2''-terpyridine N'-oxide

4-tert-butyl-4'-ethoxycarbonyl-2,2':6',2''-terpyridine N'-oxide

Conditions
ConditionsYield
With potassium phosphate; methyldi-t-butylphosphine; palladium diacetate In toluene at 120℃; for 24h; Inert atmosphere; Glovebox;71%
4-ethoxycarbonyl-2-(4-methoxypyridin-2-yl)pyridine N-oxide
1286763-32-3

4-ethoxycarbonyl-2-(4-methoxypyridin-2-yl)pyridine N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4''-(tert-butyl)-4'-ethoxycarbonyl-4-methoxy-2,2':6',2''-terpyridine N'-oxide

4''-(tert-butyl)-4'-ethoxycarbonyl-4-methoxy-2,2':6',2''-terpyridine N'-oxide

Conditions
ConditionsYield
With potassium phosphate; methyldi-t-butylphosphine; palladium diacetate In toluene at 120℃; for 24h; Inert atmosphere; Glovebox;67%
4-ethoxycarbonyl-2-(6-methoxypyridin-2-yl)pyridine N-oxide
1286763-24-3

4-ethoxycarbonyl-2-(6-methoxypyridin-2-yl)pyridine N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4''-(tert-butyl)-4'-ethoxycarbonyl-6-methoxy-2,2':6',2''-terpyridine N'-oxide

4''-(tert-butyl)-4'-ethoxycarbonyl-6-methoxy-2,2':6',2''-terpyridine N'-oxide

Conditions
ConditionsYield
With potassium phosphate; methyldi-t-butylphosphine; palladium diacetate In toluene at 120℃; for 24h; Inert atmosphere; Glovebox;64%
2,2'-(oxybis(3,1-phenylene))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2,2'-(oxybis(3,1-phenylene))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

C30H32N2O

C30H32N2O

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water at 80℃; for 24h;64%
2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4-tert-butylphenylboronic acid
123324-71-0

4-tert-butylphenylboronic acid

4-(tert-butyl)-2-(4-(tert-butyl)phenyl)pyridine
808142-68-9

4-(tert-butyl)-2-(4-(tert-butyl)phenyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); ethanol; sodium carbonate In benzene at 70℃; for 48h; Suzuki coupling;61%
4'-tert-butyl-4-ethoxycarbonyl-2,2'-bipyridine N-oxide

4'-tert-butyl-4-ethoxycarbonyl-2,2'-bipyridine N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4,4''-bis(tert-butyl)-4'-ethoxycarbonyl-2,2':6′,2''-terpyridine N'-oxide

4,4''-bis(tert-butyl)-4'-ethoxycarbonyl-2,2':6′,2''-terpyridine N'-oxide

Conditions
ConditionsYield
With potassium phosphate; methyldi-t-butylphosphine; palladium diacetate In toluene at 120℃; for 24h; Inert atmosphere; Glovebox;59%
C15H22BF3N2O3

C15H22BF3N2O3

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4-(tert-butyl)-2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine
1026999-80-3

4-(tert-butyl)-2-(3-(trifluoromethyl)-1H-pyrazol-5-yl)pyridine

Conditions
ConditionsYield
Stage #1: C15H22BF3N2O3; 4-(tert-butyl)-2-bromopyridine With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 70℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; water at 60℃;
58%
1H-imidazole
288-32-4

1H-imidazole

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

4-tert-butyl-2-(1H-imidazol-1-yl)pyridine
1261616-69-6

4-tert-butyl-2-(1H-imidazol-1-yl)pyridine

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; L-proline In dimethyl sulfoxide at 75℃; for 47h; Ullmann coupling; Inert atmosphere;57%
ethyl isonicotinate N-oxide
14906-37-7

ethyl isonicotinate N-oxide

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

A

4'-tert-butyl-4-ethoxycarbonyl-2,2'-bipyridine N-oxide

4'-tert-butyl-4-ethoxycarbonyl-2,2'-bipyridine N-oxide

B

4,4''-bis(tert-butyl)-4'-ethoxycarbonyl-2,2':6′,2''-terpyridine N'-oxide

4,4''-bis(tert-butyl)-4'-ethoxycarbonyl-2,2':6′,2''-terpyridine N'-oxide

Conditions
ConditionsYield
With potassium phosphate; tri-tert-butyl phosphine; palladium diacetate In toluene at 120℃; for 24h; Concentration; Inert atmosphere; Glovebox;A 57%
B 7%
tert-butyl (3R)-3-[(3E)-3-tert-butylsulfinyliminopropyl]piperidine-1-carboxylate

tert-butyl (3R)-3-[(3E)-3-tert-butylsulfinyliminopropyl]piperidine-1-carboxylate

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

tert-butyl (3R)-3-[3-(4-tert-butyl-2-pyridyl)-3-(tert-butylsulfinylamino)propyl]piperidine-1-carboxylate

tert-butyl (3R)-3-[3-(4-tert-butyl-2-pyridyl)-3-(tert-butylsulfinylamino)propyl]piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: 4-(tert-butyl)-2-bromopyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.75h;
Stage #2: tert-butyl (3R)-3-[(3E)-3-tert-butylsulfinyliminopropyl]piperidine-1-carboxylate In tetrahydrofuran; hexane at 20℃; for 4h;
57%
6-(methylsulfanyl)-2-(propan-2-yl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one
955368-93-1

6-(methylsulfanyl)-2-(propan-2-yl)-1H,2H,3H-pyrazolo[3,4-d]pyrimidin-3-one

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

1-(4-(tert-butyl)pyridin-2-yl)-2-isopropyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

1-(4-(tert-butyl)pyridin-2-yl)-2-isopropyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane at 90℃;56.5%
2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

phenylboronic acid
98-80-6

phenylboronic acid

4-(tert-butyl)-2-phenylpyridine
53911-36-7

4-(tert-butyl)-2-phenylpyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene Inert atmosphere; Reflux;55%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene at 70℃; for 16h; Inert atmosphere;
2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

2-bromo-4-(tert-butyl)-6-fluoropyridine

2-bromo-4-(tert-butyl)-6-fluoropyridine

Conditions
ConditionsYield
With silver(II) fluoride In acetonitrile at 20℃; Inert atmosphere; Autoclave;51%
2,2'-(4,6-difluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
1136948-11-2

2,2'-(4,6-difluoro-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-bromo-4-(tert-butyl)pyridine
50488-34-1

2-bromo-4-(tert-butyl)pyridine

1,5-bis(4-tert-butylpyridine-2-yl)-2,4-difluorobenzene

1,5-bis(4-tert-butylpyridine-2-yl)-2,4-difluorobenzene

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane for 48h; Suzuki-Miyaura Coupling; Inert atmosphere; Reflux;50%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane for 48h; Reflux;50%

50488-34-1Relevant articles and documents

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

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, (2021/02/19)

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs

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, (2016/01/09)

A bis-tridentate iridium complex represented by a formula (I): where R3 to R8, R21 to R23, R9, R10, X1, X2, and X3 are as defined in the specification.

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

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Paragraph 0173-0175, (2016/11/21)

A compound including a ligand L according to formula I, a first device and a formulation containing the same are disclosed. In the compound including the ligand L of formula I, R^1 and R^2 are independently selected from group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, cyano, and combinations thereof; two adjacent substituents of R^1 or R^2 are optionally joined to form a fused ring; a ligand L is coordinated to transition metal M having an atomic number greater than 40; R^1 represents mono, di, tri, or tetra-substitution, or no substitution; R^2 represents mono, di, or tri-substitution, or no substitution; and at least one substituent of R^1 or R^2 is cyano.COPYRIGHT KIPO 2015

Pyrrolopyrazine Kinase Inhibitors

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, (2011/10/10)

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables n, p, q, Q, X, X′ and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

A simple synthesis of functionalized 3-methyl-1-pyridinyl-1H-imidazolium salts as bidentate N-heterocyclic-carbene precursors and their application in Ir-catalyzed arene borylation

Peters, Martin,Breinbauer, Rolf

supporting information; experimental part, p. 6622 - 6625 (2011/02/21)

The selective alkylation of functionalized 2-(1H-imidazol-1-yl)pyridines 1 furnishes 3-methyl-1-pyridinyl-1H-imidazolium salts 2, which can be deprotonated to deliver strongly electron-donating bidentate N-heterocyclic carbene ligands (NHC). The synthesis of these ligands and their application in the iridiumcatalyzed C-H activated borylation of arenes with its current scope and limitations are reported.

Homogeneous catalytic transfer dehydrogenation of alkanes with a group 10 metal center

Khaskin, Eugene,Lew, Daniel L.,Pal, Shrinwantu,Vedernikov, Andrei N.

supporting information; experimental part, p. 6270 - 6272 (2010/02/16)

Unambiguous catalytic homogeneous alkane transfer dehydrogenation was observed with a group 10 metal complex catalyst, LPtII(cyclo-C 6H10)H, supported by a lipophilic dimethyl-di(4-tert- butyl-2-pyridyl)borate anionic ligand and tert-butylethene as the sacrificial hydrogen acceptor.

Direct, Regiospecific 2-Lithiation of Pyridines and Pyridine 1-Oxides with in Situ Electrophilic Trapping

Taylor, Stephen L.,Lee, David Y.,Martin, J. C.

, p. 4156 - 4158 (2007/10/02)

Efficient synthetic routes to 2-substituted pyridines and 2,6-disubstituted pyridine 1-oxides involving direct lithiation with the sterically hindered base lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the presence of electrophiles that are compatible with the base, e.g., trimethylsilyl chloride (Me3SiCl) and hexafluoroacetone (HFA), are described.

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