50488-34-1Relevant articles and documents
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
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, (2021/02/19)
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
Heteroleptic Ir(III) phosphors with bis-tridentate chelating architecture for high efficiency OLEDs
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, (2016/01/09)
A bis-tridentate iridium complex represented by a formula (I): where R3 to R8, R21 to R23, R9, R10, X1, X2, and X3 are as defined in the specification.
ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
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Paragraph 0173-0175, (2016/11/21)
A compound including a ligand L according to formula I, a first device and a formulation containing the same are disclosed. In the compound including the ligand L of formula I, R^1 and R^2 are independently selected from group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, cyano, and combinations thereof; two adjacent substituents of R^1 or R^2 are optionally joined to form a fused ring; a ligand L is coordinated to transition metal M having an atomic number greater than 40; R^1 represents mono, di, tri, or tetra-substitution, or no substitution; R^2 represents mono, di, or tri-substitution, or no substitution; and at least one substituent of R^1 or R^2 is cyano.COPYRIGHT KIPO 2015
Pyrrolopyrazine Kinase Inhibitors
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Page/Page column 97, (2011/10/10)
The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables n, p, q, Q, X, X′ and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
A simple synthesis of functionalized 3-methyl-1-pyridinyl-1H-imidazolium salts as bidentate N-heterocyclic-carbene precursors and their application in Ir-catalyzed arene borylation
Peters, Martin,Breinbauer, Rolf
supporting information; experimental part, p. 6622 - 6625 (2011/02/21)
The selective alkylation of functionalized 2-(1H-imidazol-1-yl)pyridines 1 furnishes 3-methyl-1-pyridinyl-1H-imidazolium salts 2, which can be deprotonated to deliver strongly electron-donating bidentate N-heterocyclic carbene ligands (NHC). The synthesis of these ligands and their application in the iridiumcatalyzed C-H activated borylation of arenes with its current scope and limitations are reported.
Homogeneous catalytic transfer dehydrogenation of alkanes with a group 10 metal center
Khaskin, Eugene,Lew, Daniel L.,Pal, Shrinwantu,Vedernikov, Andrei N.
supporting information; experimental part, p. 6270 - 6272 (2010/02/16)
Unambiguous catalytic homogeneous alkane transfer dehydrogenation was observed with a group 10 metal complex catalyst, LPtII(cyclo-C 6H10)H, supported by a lipophilic dimethyl-di(4-tert- butyl-2-pyridyl)borate anionic ligand and tert-butylethene as the sacrificial hydrogen acceptor.
Direct, Regiospecific 2-Lithiation of Pyridines and Pyridine 1-Oxides with in Situ Electrophilic Trapping
Taylor, Stephen L.,Lee, David Y.,Martin, J. C.
, p. 4156 - 4158 (2007/10/02)
Efficient synthetic routes to 2-substituted pyridines and 2,6-disubstituted pyridine 1-oxides involving direct lithiation with the sterically hindered base lithium 2,2,6,6-tetramethylpiperidide (LiTMP) in the presence of electrophiles that are compatible with the base, e.g., trimethylsilyl chloride (Me3SiCl) and hexafluoroacetone (HFA), are described.
