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51115-67-4

51115-67-4

Identification

  • Product Name:Butanamide,N,2,3-trimethyl-2-(1-methylethyl)-

  • CAS Number: 51115-67-4

  • EINECS:256-974-4

  • Molecular Weight:171.283

  • Molecular Formula: C10H21NO

  • HS Code:29242990

  • Mol File:51115-67-4.mol

Synonyms:2-Isopropyl-N,2,3-trimethylbutanamide;Cooling Sensate WS 23; N,2,3-Trimethyl-2-isopropylbutanamide; WS 23; WS 23 (coolingagent)

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowed

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Isopropyl-N,2,3-trimethylbutanamide
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC)
  • Packaging:5g
  • Price:$ 21
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Isopropyl-N,2,3-trimethylbutyramide >98.0%(GC)
  • Packaging:25g
  • Price:$ 56
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-Isopropyl-N,2,3-trimethylbutanamide 95+%
  • Packaging:500g
  • Price:$ 267
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:2-Isopropyl-N,2,3-trimethylbutanamide 95+%
  • Packaging:1000g
  • Price:$ 446
  • Delivery:In stock
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  • Manufacture/Brand:Chem-Impex
  • Product Description:2-Isopropyl-N,2,3-trimethylbutyramide,99.5-100.0%(GC),meetsFGspecifications,KOSHER,FEMA3804 99.5-100.0%(GC)
  • Packaging:5G
  • Price:$ 29.12
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:N,2,3-Trimethyl-2-isopropylbutamide 95%
  • Packaging:25g
  • Price:$ 363
  • Delivery:In stock
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  • Manufacture/Brand:Apolloscientific
  • Product Description:N,2,3-Trimethyl-2-isopropylbutamide 95%
  • Packaging:5g
  • Price:$ 153
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:N,2,3-TRIMETHYL-2-ISOPROPYLBUTAMIDE 95.00%
  • Packaging:5G
  • Price:$ 866.75
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:2-Isopropyl-N,2,3-trimethylbutanamide 97%
  • Packaging:100g
  • Price:$ 71
  • Delivery:In stock
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Relevant articles and documentsAll total 6 Articles be found

Method of using solid acid catalyst to synthesize amide-type cooling agent

-

Paragraph 0029-0032; 0037-0044; 0049-0060, (2019/10/04)

The invention belongs to the technical field of compound preparation, and discloses a method of using a solid acid catalyst to synthesize an amide-type cooling agent. According to the method, 2,2-diisopropyl propane nitrile, C1-C6 lower aliphatic alcohols, and water are taken as the raw materials; and under the action of a solid acid catalyst, thermostatic alcoholysis circular reactions are carried out in a fixed bed reactor. Solid acids are used to replace liquid acids, the problem that a large amount of low concentration acidic wastewater is generated in conventional cooling agent production is solved, the discharge of waste solid, waste gas, and wastewater is reduced, at the same time, the corrosion on production equipment is largely reduced; the method is green and environmentally friendly; a fixed bed reactor is adopted, an outer circulation type reaction technology is used, the alcoholysis process of converting cyano groups into N-alkyl amide is smoothly carried out, the lower aliphatic alcohols can be circularly used after being separated by a gas-liquid separator; the raw material waste is reduced, and continuous production is realized.

Synthetic method of cooling agent N,2,3-trimethyl-2-isopropyl butylamide

-

Paragraph 0020; 0021; 0024, (2018/05/16)

The invention discloses a synthetic method of cooling agent N,2,3-trimethyl-2-isopropyl butylamide. The synthetic method comprises the following steps: (1) enabling methyl acetoacetate to react with 2-bromopropane under the condition of strong alkali to obtain 3,3-diisopropyl acetoacetate methyl ester; (2) enabling the obtained 3,3-diisopropyl acetoacetate methyl ester to react with ethylene glycol, so that keto-carbonyl groups are protected, hydrolyzing ester into hydroxyl in the presence of a reducing agent, then enabling the hydroxyl to react with p-methyl benzene sulfonic chloride, then removing parabensulphonate, and obtaining 3-isopropyl-4-methyl-2-pentanone; and (3) enabling the 3-isopropyl-4-methyl-2-pentanone to react with hydroxylamine hydrochloride, and then performing the beckmann rearrangement under an acid condition to obtain N,2,3-trimethyl-2-isopropyl butylamide. According to the method, the N,2,3-trimethyl-2-isopropyl butylamide is successfully obtained by virtue of methylation of ester groups and the Beckmann rearrangement, and a novel synthetic method is provided for synthesizing WS-3; and moreover, the method is high in yield and suitable for mass production.

Lower primary alkanols and their esters in a Ritter-type reaction with nitriles. An efficient method for obtaining N-primary-alkyl amides

Lebedev, Mikhail Y.,Erman, Mark B.

, p. 1397 - 1399 (2007/10/03)

N-Primary-alkyl amides RCONHR1 were obtained by a Ritter-type reaction of nitriles RCN with lower primary alkanols R1OH or their esters in the presence of acids.

Method for making amides

-

, (2008/06/13)

The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increasing the yield of the product.

Method for making amides

-

, (2008/06/13)

The invention relates to the manufacture of amide compounds provided through the reaction of nitrile compounds and a sulfate compound to form the related amide compound. In a preferred embodiment a diol or a triol is employed as a solvent, thereby increasing the yield of the product.

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With activated PMA-SiO2 solid acid catalyst; In water; at 90 ℃; for 5h; Reagent/catalyst; Temperature;
94%
3-isopropyl-3,4-dimethyl-pentan-2-one
67029-99-6

3-isopropyl-3,4-dimethyl-pentan-2-one

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; for 2h;
49.7%
2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With PPA; at 140 ℃; for 10h;
95%
methanol
67-56-1

methanol

2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

2-isopropyl-2,3-dimethyl-butyric acid amide
102450-54-4

2-isopropyl-2,3-dimethyl-butyric acid amide

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With sulfuric acid; acetic acid; at 100 ℃; for 47h; Further Variations:; Reagents; Temperatures; Product distribution;
N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
70%
methanol
67-56-1

methanol

2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With activated PMA-SiO2 solid acid catalyst; In water; at 90 ℃; for 5h; Reagent/catalyst; Temperature;
94%
3-isopropyl-3,4-dimethyl-pentan-2-one
67029-99-6

3-isopropyl-3,4-dimethyl-pentan-2-one

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; for 2h;
49.7%
2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With PPA; at 140 ℃; for 10h;
95%
methanol
67-56-1

methanol

2,2-diisopropylpropionitrile
55897-64-8

2,2-diisopropylpropionitrile

2-isopropyl-2,3-dimethyl-butyric acid amide
102450-54-4

2-isopropyl-2,3-dimethyl-butyric acid amide

N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
With sulfuric acid; acetic acid; at 100 ℃; for 47h; Further Variations:; Reagents; Temperatures; Product distribution;
N,2,3-trimethyl-2-isopropylbutanamide
51115-67-4

N,2,3-trimethyl-2-isopropylbutanamide

Conditions
Conditions Yield
70%

Global suppliers and manufacturers

Global( 140) Suppliers
  • Company Name
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  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Trading Company
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • COLORCOM LTD.
  • Business Type:Manufacturers
  • Contact Tel:+86-571-89007001
  • Emails:medkem@medkem.cn
  • Main Products:1
  • Country:China (Mainland)
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