51782-10-6Relevant articles and documents
A 4-acetamidomethyl methyl cyclohexyl method for producing methyl formate
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Paragraph 0041; 0044; 0045, (2017/02/28)
The invention relates to a preparation method of methyl 4-acetylaminomethyl hexahydrobenzoate. The method comprises the following steps: adding methyl paracyanobenzoate into a reaction kettle, adding a metal catalyst I and a cocatalyst II, heating while stirring to react under hydrogen gas conditions for 6-10 hours by using acetic anhydride as a solvent, filtering, and distilling to obtain the methyl acetylaminomethyl benzoate; and adding the obtained methyl acetylaminomethyl benzoate into a reaction kettle, adding a solvent V, a metal catalyst III and a cocatalyst IV, heating while stirring to completely react under hydrogen gas conditions, filtering, and distilling to recover the solvent, thereby obtaining the methyl 4-acetylaminomethyl hexahydrobenzoate. The synthesis technique of preparing the methyl 4-acetylaminomethyl hexahydrobenzoate from the initial raw material methyl paracyanobenzoate has the advantages of accessible raw materials, low cost, high yield and the like, and is simple to operate and suitable for industrial production. The product can be further used for preparing the trans-4-aminomethylcyclohexyl formic acid, and has huge application potential.