521-61-9Relevant articles and documents
REVISION OF THE STRUCTURE OF PRZEWALSKINONE B
Kelly, T. Ross,Ma, Zhenkun,Xu, Wei
, p. 7713 - 7714 (1992)
Biosynthetic considerations suggested that the recently assigned structure (1) of Przewalskinone B was incorrect.Synthetic studies support the revision of the structure of przewalskinone B to 3.
Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones
Cui, Xing-Ri,Tsukada, Maiko,Suzuki, Nao,Shimamura, Takeshi,Gao, Li,Koyanagi, Jyunichi,Komada, Fusao,Saito, Setsuo
, p. 1206 - 1215 (2008)
Seven hydroxyanthraquinone derivatives, 1-7, were isolated from the root of Rheum palmatum (Polygonaceae). Two propionated anthraquinone derivatives, 8 and 9, were synthesized. Four hydroxynaphthoquinone derivatives, 13, 14, 16 and 21, were isolated from the root of Lithospermum erythrorhizon Sieb. et Zucc. (Boraginaceae) and also three naphthoquinone derivatives, 19, 22 and 23, were isolated from the root of Macrotomia euchroma (Royle) Pauls. (Boraginaceae). The cytotoxicity of the anthraquinone and naphthoquinone derivatives on P-gp-underexpressing HCT 116 cells and P-gp-overexpressing Hep G2 cells was examined by MTT assay. Among the anthraquinone derivatives, compounds 3-5 which had OH, CH2OH and COOH substituent groups on the anthraquinone skeletons, respectively, showed potent growth inhibitory activities against both types of cancer cells (IC50 values: 5.7 ± 0.9 to 13.0 ± 0.7 μM in the case of HCT 116 cells and 5.2 ± 0.7 to 12.3 ± 0.9 μM in the case of Hep G2 cells). All hydroxynaphthoquinone derivatives isolated in this study exhibited extremely potent growth inhibitory activities against both types of cancer cells (IC50 values: 0.3 ± 0.09 to 0.46 ± 1.0 μM in the case of HCT 116 cells and 0.22 ± 0.03 to 0.59 ± 0.06 μM in the case of Hep G2 cells) as well as shikonin 10 (IC50 values: 0.32 ± 0.02 μM in the case of HCT 116 cells and 0.24 ± 0.03 μM in the case of Hep G2 cells).
PHYSCION-8-O-GENTIOBIOSIDE FROM RHAMNUS VIRGATA
Kalidhar, S. B.,Sharma, Pushpa
, p. 1196 - 1197 (1984)
A new anthraquinone diglucoside isolated from rhamnus virgata has been shown to be physcion-8-O-b-gentiobioside on the basis of spectral and othe evidence.Key words: Rhamnus virgata; Rhamnaceae; physcion; physcion-8-O-gentiobioside; anthraquinone.
Hesse
, (1917)
Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser
Atchison, Jordan,Kamila, Sukanta,McEwan, Conor,Nesbitt, Heather,Davis, James,Fowley, Colin,Callan, Bridgeen,McHale, Anthony P.,Callan, John F.
supporting information, p. 16832 - 16835 (2015/11/27)
A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
Characterization of emodin metabolites in Raji cells by LC-APCI-MS/MS
Koyama, Junko,Takeuchi, Atsuko,Morita, Izumi,Nishino, Yu,Shimizu, Maki,Inoue, Munetaka,Kobayashi, Norihiro
experimental part, p. 7493 - 7499 (2011/02/23)
A rapid, simple, and sensitive liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed for the identification and quantification of emodin metabolites in Raji cells, using aloe-emodin as an internal standard. Analyses were performed on an LC system employing a Cosmosil 5C18 AR-II column and a stepwise gradient elution with methanol-20 mM ammonium formate at a flow rate of 1.0 mL/min operating in the negative ion mode. As a result, the starting material emodin and its five metabolites were detected by analyzing extracts of Raji cells that had been cultivated in the presence of emodin. The identification of the metabolites and elucidation of their structures were performed by comparing their retention times and spectral patterns with those of synthetic samples. In addition to the major metabolite 8-O-methylemodin, four other metabolites were assigned as ω-hydroxyemodin, 3-O-methyl-ω-hydroxyemodin, 3-O-methylemodin (physcion), and chrysophanol.