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Emodin
Cas No: 518-82-1
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Emodin CAS 518-82-1
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518-82-1 Usage

Fire Hazard

Flash point data for Emodin are not available; however, Emodin is probably combustible.

Diuretic effect

Both rhein and emodin have evident diuretic effect. The urine volume increased to peak two to four hours after dosing, and in the meanwhile the amounts of Na+ and K+ discharges were also reached to the peak. Aloe-emodin and chrysophanol were less effective in diuretic property as compared with rhein and emodin. The mechanism is contributed to the inhibitory effect of rhein and emodin on renal medullary Na+, K+-ATPase. The Na+ re-absorption in renal tubules is mainly active transport which needs energy from ATP hydrolysis catalyzed by the Na+, K+-ATPase. When the enzyme is inhibited, Na+ re-absorption would decrease because of insufficient energy supply, which leads to water discharge increase along with the increase of Na+ discharge. When distal convoluted tubule Na+ increases, promote Na+-K+ exchange would be promoted, resulting in increase in K+ discharge.

Uses

Occurs mostly as the rhamnoside (see Frangulin) in rhubarb root. Cathartic.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Emodin emits acrid smoke and irritating fumes.

Reactivity Profile

Emodin may be sensitive to prolonged exposure to light. Probably a weak acid due to the phenolic functional groups.

Uses

1. The product can be used as a laxative. As it is susceptible to oxidative damage within the body, its diarrhea activity is actually very weak. However, it can be compounded with glucose to form a glycoside with diarrhea activity. Both emodin-1-O-β-D-glucoside and emodin-8-O-β-D-glucoside are glycosides formed through combination of emodin and glucose.  The only different between the two are the binding sites.  The two glycosides coexist in Radix et Rhizoma Rhei.
2. intermediate;health products material.

Production method

Emodin is a plant laxative widely present in plant organs such as roots of Radix et Rhizoma Rhei, bark and root bark of buckthorn and cassia seeds. Emodin can be extracted from roots and rhizomes of Radix et Rhizoma Rhei. It also can be obtained by synthesis, for example, using 2-methyl-anthraquinone, or 3, 5-nitro-phthalic anhydride and m-cresol as the raw material.

Uses

antibacterial, antineoplastic, cathartic, tyrosine kinase inhibitor

Chemical constituents

There have been more than 130 compounds isolated and characterized from a variety species of Rheum, including anthraquinones and anthraquinone glycosides, anthrones, bianthrones and bianthrone glycosides, stilbenes and stilbene glycosides, gallate, naphthalene derivatives, chromanones and chromanone glycosides, banzylethylketone, tannins and so on. Among them the anthraquinones are the most important and representative ingredients. Free anthraquinones mainly include rhein, emodin, physcion, aloe-emodin, and chrysophanol. And anthraquinone glycosides mainly include chrysophanol-1-glucoside, chrysophanol-8-glucoside, emodin-1-glucoside, emodin-8-glucoside, physcion-8-glucoside, physcion-8-gentiobiosiden, aloe-emodin-8-glucoside, aloe-emodin-3-glucoside, and rhein-8-glucoside. Bianthrone glycosides include sennosides A, B, C, D, E, and F. Stilbenes and stilbene glycosides include rhaponticin, rhapontigenin and de-oxyrhaponticin.
Radix et Rhizoma Rhei contains a variety of tannins, both hydrolyzable tannins and condensed tannins[4]. Hydrolyzable tannins and its related compounds contain a variety of pentagalloylglucose and 1-O-galloyl-6-O-cinnamoyl-β-D-glucose. Condensed tannins and its related compounds contain catechin, epicatechin and its polymers. In addition, Radix et Rhizoma Rhei also contains a variety of banzylethylketone glycosides.

Air & Water Reactions

Insoluble in water.

Biological Activity

Naturally occurring anthraquinone that displays a range of biological activities. Exhibits anti-inflammatory, antitumor and neuroprotective effects.

Radix et Rhizoma Rhei

Radix et Rhizoma Rhei is the dry root or rhizome of Rheum palmatum L, Rheum officinale Baill, and Rheum tanguticum Maxim. ex Balf. in the genus Rheum of the family Polygonaceae. Rheum tanguticum Maxim. ex Balf has slender pinnate leaves with three deep lobes and dense inflorescence branches, often erect, clinging to the stem, which are the main difference of it from Rheum palmatum L. The main difference between Rheum tanguticum Maxim. ex Balf. and the other two species mentioned above are its lobed leaves with big serrate or broadly triangular margin, large and yellow-white flowers, oval-shaped flower buds and patulous branches. There are about 60 Rheum species all over the world, of which about 50 are in China.
Morphological Characteristics: herbaceous perennial about two meters high. Rhizomes and roots are fleshy and yellowish-brown in color. The stem is erect, smooth, hairless and hollow. The basal leaf has a fleshy, long and sturdy petiole, about as long as the leaf blade. The leaf blade is broadly ovate or nearly round in shape, up to 40 cm in diameter, palmate-cleft with three to five (or to seven) lobes and each lobe sometimes also palmate-cleft or serrate. The leaf base is slightly heart-shaped. The stem leaf is small, shortly stalked. The ocrea is membranous and densely pubescent.
Habitat and distribution: Grow in mountain areas, forest margins or grassland, wild or cultivated and distributed in Shaanxi, southeastern Gansu, Qinghai, western Sichuan, northwestern Yunnan and Eastern Tibet.
Cultivation: suitable for growing in places with cool and moist climate and with deep soil layer that contains humus-rich sandy loam or calcareous loam, rather than growing in cold places with high temperature and humidity.
Harvest: harvest during September to October, select plants that have grown more than three years, dig up the rhizomes and roots, remove the leaves, stems, rootlets, scrape the bark and buds, and then dried in air or in an oven, or sliced and dried.
the Radix et Rhizoma Rhei
Figure 1 is an image of the Radix et Rhizoma Rhei

Physical and chemical properties

Emodin, also known by the Chemical name 1, 3, 8-trihydroxy-6-methyl-anthraquinone with a molecular formula of C15H10O5 and a molecular weight of 270.24, exists in the form of free emodin or emodin glycosides in rhizomes and roots of Rheum palmatum L, Rheum officinale Baill, and Rheum tanguticum Maxim. ex Balf. in the family Polygonaceae. In a form of orange-yellow crystals of melting point of 256-257℃ that can sublimate under a vacuum of 1,600 Pa, the compound is soluble in ethanol, sodium hydroxide, sodium carbonate and aqueous ammonia, slightly soluble in ether, chloroform, carbon tetrachloride and benzene, and almost insoluble in water. Its form as emodin triacetate is yellow crystals of melting point of 197℃, and the form of emodin 3-methyl ether (also known as physcion) is dark-red needle crystals of melting point of 207 ℃. The compound can be obtained by chemical synthesis or by extraction from plants.
Aloe-emodin is one of the main components of aloe essential oil, present in the form of aloe-emodin in aloe, or present in the form of glycosides in rhubarb, senna and aloe.

Antitumor effect

Pharmacological studies have found that anthraquinone derivatives in Radix et Rhizoma Rhei, rhein, emodin and aloe-emodin showed obvious inhibitory effect on cancers, especially on cancers such as melanoma, P388 leukemia and Ehrlich ascites carcinoma. The polysaccharides contained in Radix et Rhizoma Rhei could markedly inhibit the cells of sarcoma S180. And a concentration of 10 μg/ml emodin could reduce the maximum growth density and the mitotic index of human lung cancer cell line A-549, and apparently decreased the incorporation of tritiated thymidine and the level DNA content. It was also found that the drug could relatively increase the number of cells at the G1 and S stages and decreased the number of aneuploid cells as well as the number of cells at the G2/M phase, with a sinistral displacement of the peak in the DNA histogram. These results suggested that emodin has an obvious inhibitory effect on human lung cancer A-549 cells. The antitumor mechanism of Radix et Rhizoma Rhei is presently considered to be the inhibition of respiration and DNA biosynthesis of cancer cells. It is also believed that rhein and emodin may destroy the cancer cells directly.

Chemical Properties

red-orange powder

Chemical properties

Orange needles of melting point of 256-257℃ (259-260℃); soluble in alcohol, slightly soluble in ether, chloroform and benzene, and insoluble in water. The solution color would become cherry red when it is dissolved in aqueous caustic solutions, aqueous solution of sodium carbonate or ammonia solution.

Purification Methods

Archin forms orange needles from EtOH, Et2O, *C6H6, toluene or pyridine. It sublimes above 200o at 12mm. [Tutin & Clewer J Chem Soc 99 946 1911, IR: Bloom et al. J Chem Soc 178 1959, UV: Birkinshaw Biochem J 59 495 1955, Raistrick Biochem J 34 159 1940.] 1R,2S-(-)Ephedrine see (-)-ephedrine (1R,2S-2-methylamino-1-phenylpropanol) in “Miscellaneous” in Chapter 6.

General Description

Orange needles or powder.

518-82-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (E7881)  Emodin  from Frangula bark, ≥90% (HPLC) 518-82-1 E7881-250MG 3,641.04CNY Detail
Sigma (E7881)  Emodin  from Frangula bark, ≥90% (HPLC) 518-82-1 E7881-50MG 1,048.32CNY Detail
TCI America (E0500)  Emodin  >96.0%(HPLC) 518-82-1 1g 2,990.00CNY Detail
TCI America (E0500)  Emodin  >96.0%(HPLC) 518-82-1 100mg 570.00CNY Detail

518-82-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name emodin

1.2 Other means of identification

Product number -
Other names 6-Methyl-1,3,8-trihydroxyanthraquinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:518-82-1 SDS

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