52331-62-1

Basic information

• Product Name: 2-Propenoyl chloride, 3-cyclohexyl-
• Synonyms: 2-Propenoyl chloride,3-cyclohexyl
• CAS NO: 52331-62-1
• Molecular Formula: C9H13ClO
• Molecular Weight: 172.655
• Mol File: 52331-62-1.mol

Chemical Properties

• Boiling Point: 135 °C(Press: 10 Torr)
• Density: 1.144±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Propenoyl chloride, 3-cyclohexyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-cyclohexyl-(52331-62-1)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-cyclohexyl-(52331-62-1)

Safety Data

• Hazardous Substances Data: 52331-62-1(Hazardous Substances Data)

Upstream product

• 4484-35-9 3-cyclohexylacrylic acid 
• 19096-89-0 methoxymethylenecyclohexane 
• 108-94-1 cyclohexanone 
• 56453-86-2 (E)-3-cyclohexylprop-2-enoic acid 
• 2043-61-0 cyclohexanecarbaldehyde 

Downstream Products

• 27045-59-6 4-(3-cyclohexyl-acryloyl)-morpholine 
• 26094-77-9 4-(3-cyclohexyl-acryloyl)-2-methyl-morpholine 
• 71675-56-4 (Z)-3-Cyclohexyl-acrylic acid 4-dimethylamino-butyl ester 
• 120680-93-5 2-((E)-3-Cyclohexyl-acryloylamino)-3-phenyl-propionic acid 
• 1171166-00-9 6-cyclohexyl-3-phenyl-2-selenoxoperhydro-1,3-selenazin-4-one 
• 1255709-90-0 5-bromo-2-(2-cyclohexylvinyl)-1H-benzimidazole 
• 1255710-81-6 3-cyclohexyl-N-(6'-fluoro-3-nitro-2'-trifluoromethylbiphenyl-4-yl)acrylamide 
• 1365108-93-5 C₂₁H₂₀F₃N₃O₃ 
• 1365107-87-4 C₂₁H₂₀F₃N₃ 
• 1365107-89-6 2-(2-cyclohexylvinyl)-5-(2-fluoro-6-trifluoromethylphenyl)-1H-benzimidazole 
• 1365108-79-7 C₂₁H₂₁FN₂O₃ 
• 1255710-08-7 2-(2-cyclohexylvinyl)-5-(2-fluorophenyl)-1H-benzimidazole 
• 1365108-87-7 C₂₂H₂₁F₃N₂O₄ 
• 1255709-91-1 2-(2-cyclohexylvinyl)-5-(2-trifluoromethoxyphenyl)-1H-benzimidazole 

Relevant articles and documents

Quorum sensing and nf-κb inhibition of synthetic coumaperine derivatives from piper nigrum

Bacterial communication, termed Quorum Sensing (QS), is a promising target for virulence attenuation and the treatment of bacterial infections. Infections cause inflammation, a process regulated by a number of cellular factors, including the transcription Nuclear Factor kappa B (NF-κB); this factor is found to be upregulated in many inflammatory diseases, including those induced by bacterial infection. In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper (Piper nigrum), for Quorum Sensing Inhibition (QSI) and NF-κB inhibitory activities. Of the compounds tested, seven were found to have high QSI activity, three inhibited bacterial growth and five inhibited NF-κB. In addition, some of the CP compounds were active in more than one test. For example, compounds CP-286, CP-215 and CP-158 were not cytotoxic, inhibited NF-κB activation and QS but did not show antibacterial activity. CP-154 inhibited QS, decreased NF-κB activation and inhibited bacterial growth. Our results indicate that these synthetic molecules may provide a basis for further development of novel therapeutic agents against bacterial infections.

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described.

BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

Organocatalysis in conjugate amine additions. Synthesis of β-amino acid derivatives

Conjugate addition of O-protected hydroxylamines to pyrazole-derived enoates proceeds with high efficiency and enantioselectivity when chiral thioureas are used as activators. A wide variety of substrates undergo conjugate amine addition providing access to enantioenriched β-amino acid derivatives. Structural requirements for the optimal thiourea catalyst have been established, and the results suggest that it operates as a bifunctional catalyst. Copyright