19096-89-0Relevant academic research and scientific papers
Antimalarial effect of 3-methoxy-1,2-dioxetanes on the erythrocytic cycle of Plasmodium falciparum
Lopes, Nicolas S.,Yoshitake, Ariane M.,Silva, Adriana F.,Oliveira, Vani X.,Silva, Leandro S.,Pinheiro, Ana A. S.,Ciscato, Luiz Francisco M. L.
, p. 1373 - 1377 (2015)
The antimalarial activity of peroxides most likely originates from their interaction with iron(II) species located inside the malaria parasite, which forms destructive radical species through a Fenton-like mechanism. This article reports the first evaluat
Chemiluminescence-promoted oxidation of alkyl enol ethers by NHPI under mild conditions and in the dark
Anderson,Andia, Alexander A.,Woerpel
supporting information, (2021/02/03)
The hydroperoxidation of alkyl enol ethers using N-hydroxyphthalimide and molecular oxygen occurred in the absence of catalyst, initiator, or light. The reaction proceeds through a radical mechanism that is initiated by N-hydroxyphthalimide-promoted autoxidation of the enol ether substrate. The resulting dioxetane products decompose in a chemiluminescent reaction that allows for photochemical activation of N-hydroxyphthalimide in the absence of other light sources.
Practical preparation of methyl vinyl ethers through the direct coupling of ketones with CHCl2OMe promoted by Mg/TiCl4/THF
Ananthan, Bakthavachalam,Yan, Tu-Hsin
supporting information, p. 753 - 760 (2018/03/12)
Herein we utilized a new methylene carbenoid as an extremely simple and highly practical reagent for the preparation of vinyl ether with good to excellent yield. This method efficiently effects methoxymethylenation or vinyl ether formation of enolizable, nonenolizable, and sterically hindered ketones. The complexation of Ti–Mg–CHOMe was facilitated, presumably, by THF dramatically increasing the feasibility; and scope of this protocol is to produce vinyl ethers which can be used as convenient building blocks for the preparation of biologically useful molecules.
Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof
-
Paragraph 0127; 0128, (2015/06/17)
Spiroindoline carbocycle derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis
Silica-immobilized chiral dirhodium(II) catalyst for enantioselective carbenoid reactions
Chepiga, Kathryn M.,Feng, Yan,Brunelli, Nicholas A.,Jones, Christopher W.,Davies, Huw M. L.
supporting information, p. 6136 - 6139 (2014/01/17)
A silica-supported dirhodium(II) tetraprolinate catalyst was synthesized in four steps from l-proline and used in a range of enantioselective transformations of donor/acceptor carbenoids. These include cyclopropenation, cyclopropanation, tandem ylide form
Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia
Calvo, Raul R.,Meegalla, Sanath K.,Parks, Daniel J.,Parsons, William H.,Ballentine, Shelley K.,Lubin, Mary Lou,Schneider, Craig,Colburn, Raymond W.,Flores, Christopher M.,Player, Mark R.
scheme or table, p. 1903 - 1907 (2012/04/04)
Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described.
Synthesis of Cyclic and Acyclic Enol Ethers (Vinyl Ethers)
Gassman, Paul G.,Burns, Stephen J.,Pfister, Keith B.
, p. 1449 - 1457 (2007/10/02)
A general method has been developed for the conversion of both cyclic and acyclic acetals of cyclic ketones, acyclic ketones, and aldehydes into enol ethers through treatment of the acetal with trimethylsilyl triflate in the presence of N,N-diisopropylethylamine.The range of isolated yields of enol ethers from the various classes of acetals was as follows: cyclic acetals of cyclic ketones, 83-98percent; acyclic acetals of ketones, 72-94percent; acyclic and cyclic acetals of aldehydes, 65-90percent.
METHANOLYSIS OF DIMETHYL (1-DIAZO-2-OXOPROPYL)PHOSPHONATE: GENERATION OF DIMETHYL (DIAZOMETHYL)PHOSPHONATE AND REACTION WITH CARBONYL COMPOUNDS
Ohira, Susumu
, p. 561 - 564 (2007/10/02)
Dimethyl (1-diazo-2-oxopropyl)phosphonate (3) was transformed to dimethyl (diazomethyl)phosphonate (4), which was used for the synthesis of enol ethers or alkyne without isolation.
Hetero-Diels-Alder Reaction of Enaminecarbaldehydes An Entry to Branched Aminosugars
Tietze, Lutz F.,Voss, Edgar,Harms, Klaus,Sheldrick, George M.
, p. 5273 - 5276 (2007/10/02)
N-acyl-enaminecarbaldehydes 6a - g with an electron accepting group in the α-position react in a hetero-Diels-Alder cycloaddition with enolethers 7a - g to 4-amino-dihydropyrans 8a - g, 9a - g and 10a - g.This reaction represents a convenient entry to branched aminosugars of the garosamine-type.The rate of the cycloaddition depends strongly on the N-acyl group in 6.However, the phtalimide 11 does not react because of deconjugation of the electron accepting function in the α-position.
