530145-62-1

Basic information

• Product Name: (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide
• Synonyms: (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide;(R)-N-[(5-Cyano-2-nitrophenyl)Methyl]-N-[1-(hydroxyMethyl)-2-phenylethyl]thiophene-2-sulfonaMide
• CAS NO: 530145-62-1
• Molecular Formula: C₂₁H₁₉N₃O₅S₂
• Molecular Weight: 457.52266
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 530145-62-1.mol

Chemical Properties

• Appearance: /
• Solubility: Ethyl Acetate, Dimethylformamide, Dimethyl Sulfoxide, Tetrahydrofuran
• CAS DataBase Reference: (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide(530145-62-1)
• EPA Substance Registry System: (R)-N-(5-Cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonaMide(530145-62-1)

Safety Data

• Hazardous Substances Data: 530145-62-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide is used as a reactant for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds. These compounds are significant due to their farnesyl protein transferase inhibitory activity, which can be leveraged in the development of pharmaceuticals targeting various diseases and conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, (R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide serves as a key intermediate in the creation of various complex organic molecules. Its unique structure and reactivity make it a valuable component in the synthesis of specialized chemicals with potential applications in different industries.
Chemical Properties:
(R)-N-(5-cyano-2-nitrobenzyl)-N-(1-hydroxy-3-phenylpropan-2-yl)thiophene-2-sulfonamide is presented as a yellow solid, indicating its stability and potential for use in various chemical processes. Its physical state and color can be important factors in its handling, storage, and application in different settings.

Upstream product

• 110-86-1 pyridine 
• 16629-19-9 thiophene-2-sulfonyl chloride 
• 530145-61-0 (R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile 
• 96784-54-2 3-methyl-4-nitrobenzonitrile 
• 96631-89-9 trans-5-cyano-β-dimethylamino-2-nitrostyrene 
• 90178-82-8 3-formyl-4-nitrobenzonitrile 
• 5267-64-1 (R)-2-amino-3-phenylpropanol 

Downstream Products

• 195985-38-7 (R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-4-(thien-2-ylsulfonyl)-1H-1,4-benzodiazepine-7-carbonitrile 
• 195987-41-8 BMS-214662 
• 530145-64-3 N-[(2-amino-5-cyanophenyl)methyl]-N-[(1R)-1-(phenylmethyl)-2-[(phenylsulphonyl)oxy]ethyl]-2-thiophenesulfonamide 

Relevant articles and documents

Development of a Practical Synthesis of a Farnesyltransferase Inhibitor

The development of a new and practical synthesis for a farnesyltransferase inhibitor 1 is described. The new route started from 2-nitro-5-cyanotoluene (9) and afforded desired 1 in eight chemical transformations. The key step involved formation of sulfonamide 13 from a hindered β-hydroxyamine 12 through an in situ protection of the hydroxyl group by forming TMS ether. Ultimately, this new route was successfully demonstrated to generate >10 kg of API in 29% overall yield.

Process for the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds

Methods for the synthesis of benzodiazepine compounds having farnesyl protein transferase inhibitory activity.